Antimicrobial, Antifungal and Enzymatic Profiling of Newly Synthesized Heavy Metal Complexes of Gemifloxacin

Gemifloxacin-transition metal complexes as therapeutic candidates: antimicrobial, antifungal, anti-enzymatic, and docking studies of newly synthesized complexes

“…For the assay of urease inhibition, the method was adopted from our previously reported work with some modifications having thiourea as standard [ 13 ]. Chymotrypsin inhibitory activity was studied at 410nm by adopting Cannel Method using Chymostatin as standard.…”

“…Infrared spectroscopic data is used to characterize the metal complexes of quinolones, focusing on typical vibrations and carboxylate coordination, as a diagnostic tool. IR spectra of GMFX are quite comprehensive where OH stretching vibrations of COOH and N-H of piperazinyl ring exhibit a broad spilled band between 3500-3100 cm À1 [13,17]. Determination of metal binding mode with the carboxylate group of gemifloxacin revealed its bidentate bridging complexation in all Gemifloxacin-metal complexes and was determined by the difference (Δ ¼ ν asym (CO 2 ) -ν sym (CO 2 ) (Table 2) [13].…”

“…IR spectra of GMFX are quite comprehensive where OH stretching vibrations of COOH and N-H of piperazinyl ring exhibit a broad spilled band between 3500-3100 cm À1 [13,17]. Determination of metal binding mode with the carboxylate group of gemifloxacin revealed its bidentate bridging complexation in all Gemifloxacin-metal complexes and was determined by the difference (Δ ¼ ν asym (CO 2 ) -ν sym (CO 2 ) (Table 2) [13]. In GMFX, the carboxylic group peak appeared at 1718 cm À1 [23,24] which is shifted in all synthesized metal complexes ranging between 1627-1685 cm À1 and 1399-1412 cm À1 and were assigned as asymmetric, υ (CO2) asym, and symmetric, υ (CO 2 ) sym, respectively.…”

“…Our research group previously has reported the synthesis and biological profiling of essential and traces metal complexes of several fluoroquinolones (including 3 rd and 4 th generation agents) complexes, revealing changes in the physicochemical, spectroscopic and biological responses [ 8 , 9 , 10 ]. As evident from the research data, quinolone's absorption is well altered when given concomitantly with multivitamins, or, antacids, and other bivalent cations containing supplements [ 11 , 12 , 13 ]. In our previous study, we have already reported sparfloxacin metal complexes' response as antifungal agents where Fe 2+ –SPFX and Cd 2+ –SPFX complexes proved to be more potent than the parent molecule [ 8 ].…”