Antimicrobial, antioxidant and anti-inflammatory activities of seeds from emblica officinalis (Gaertn.)

Abstract

There is a shred of evidence to suggest that Emblica officinalis Gaertn, the botanical name for amla seeds, has greater medicinal potential than amla fruit. We conducted this work to assess the anti-inflammatory, antibacterial, and antioxidant capacities of E. officinalis seed extracts. The bioactive components from the seeds were fractionated using chloroform, hexane, methanol, and diethyl ether, according to the polarity of the solvents. The total amount of phenolic and flavonoid was estimated. Both the reducing power and antioxidant capacities of the extracts were evaluated using the DPPH (1,1-diphenyl-2-picryl-hydrazyl) technique. 15-lipoxygenase (LOX) was inhibited by seed extracts at doses ranging from 5 to 25 micrograms. In silico docking was employed to assess the results. Some human pathogenic microorganisms were tested for their antibacterial activity using the agar disc diffusion method. Escherichia coli, Proteus vulgaris, and Klebsiella pneumonia were inhibited by a methanolic extract with an IC50 value of 58g, making it the most common organic solvent extract. Methanolic extracts also showed good antioxidant and antibacterial activity. Our investigation led us to discover that amla seeds have anti-inflammatory, antioxidant, and antibacterial effects.

Antibacterial Effect of Indian Gooseberry (Phyllanthus emblica L.) Extract Against ESBL Producing Multi-Drug Resistant Bacteria

“…is one of the routinely used fruit in local traditional medicine Ayurveda (India), Traditional Chinese Medicine, and Tibetan medicine. The fruit has been reported to possess several pharmacological properties, such as analgesic, antioxidant, antiinfl ammatory, antifungal, antibacterial, anticancer, antiviral activities and chemo protective activities [11][12][13][14][15]. To reduce side eff ects of synthetic antibiotics usage in treatment of MDR diseases, the common culinary herbs that exhibit antimicrobial activity could be a source of natural drugs.…”