2022
DOI: 10.3389/fmicb.2022.932466
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Antimicrobial Blue Light for Prevention and Treatment of Highly Invasive Vibrio vulnificus Burn Infection in Mice

Abstract: Vibrio vulnificus is an invasive marine bacterium that causes a variety of serious infectious diseases. With the increasing multidrug-resistant variants, treatment of V. vulnificus infections is becoming more difficult. In this study, we explored antimicrobial blue light (aBL; 405 nm wavelength) for the treatment of V. vulnificus infections. We first assessed the efficacy of aBL against five strains of V. vulnificus in vitro. Next, we identified and quantified intracellular porphyrins in V. vulnificus to provi… Show more

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Cited by 3 publications
(11 citation statements)
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“…It has been shown that losses of viability of up to >50% is considered a significant loss of viability, [ 36 ] suggesting that the marginal loss of viability by aBL alone or aBL + chloramphenicol would likely be acceptable. Our findings mirror numerous studies that have validated the safety of aBL in vitro, [ 37–39 ] in preclinical studies, [ 7,40 ] and in clinical trials. [ 41,42 ]…”
Section: Discussionsupporting
confidence: 88%
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“…It has been shown that losses of viability of up to >50% is considered a significant loss of viability, [ 36 ] suggesting that the marginal loss of viability by aBL alone or aBL + chloramphenicol would likely be acceptable. Our findings mirror numerous studies that have validated the safety of aBL in vitro, [ 37–39 ] in preclinical studies, [ 7,40 ] and in clinical trials. [ 41,42 ]…”
Section: Discussionsupporting
confidence: 88%
“…Mice were then returned to their housing for a further 24 h, prior to euthanizing the mice, and isolating the infected skin tissue for subsequent homogenization, using Lysing Matrix D tubes (MP Biomedicals, USA) within a homogenizer (FastPrep-24™ Biomedicals, USA) and CFU determination. [7] Histological and Immunohistochemical Studies: The cell proliferation and apoptosis activity following blue light combined with chloramphenicol were assessed in naïve mice skin. In brief, 0.1% chloramphenicol solution (200 μL) was applied to the skin 30 min previously to the light exposure to allow complete penetration.…”
Section: Methodsmentioning
confidence: 99%
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