Antimicrobial catheters for reduction of symptomatic urinary tract infection in adults requiring short-term catheterisation in hospital: a multicentre randomised controlled trial

Pickard, Robert; Lam, Thomas; MacLennan, Graeme; Starr, Kath; Kilonzo, Mary; McPherson, Gladys; Gillies, Katie; McDonald, Alison; Walton, Katherine; Buckley, Brian S; Glazener, Cathryn; Boachie, Charles; Burr, Jennifer; Norrie, John; Vale, Luke; Grant, Adrian; N’Dow, James

doi:10.1016/s0140-6736(12)61380-4

Cited by 219 publications

(178 citation statements)

References 15 publications

Supporting

Mentioning

172

Contrasting

Unclassified

Order By: Relevance

“…[9][10][11][12][13][14][15] These studies have examined endpoints such as bacteriuria and symptomatic CA-UTI, or surveillance-defined UTI. 8,16,17 In a study by Pickard et al, 17 noble metal alloy catheters were found to be ineffective in reducing the incidence of symptomatic surveillance-defined UTI when used in short-term (mean, 2 days) surgical patients and they did not support the routine use of these catheters in this patient group. Lack of effect is not surprising due to the short catheterisation time and low-risk patient group.…”

Section: Discussionmentioning

confidence: 98%

A prospective interventional study to examine the effect of a silver alloy and hydrogel--coated catheter on the incidence of catheter-associated urinary tract infection

Chung¹,

Wong²,

Lai³

et al. 2017

Hong Kong Med J

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

A prospective interventional study to examine the effect of a silver alloy and hydrogel--coated catheter on the incidence of catheter-associated urinary tract infection

Chung¹,

Wong²,

Lai³

et al. 2017

Hong Kong Med J

View full text Add to dashboard Cite

“…Furthermore, as soon as the antibiotic contained in the device is exhausted, antibiotic delivery stops. Antibioticcoated surfaces have also been studied in animal and clinical studies of urinary catheters, endotracheal tubes, orthopedic devices, and vascular grafts, with contrasting clinical benefits (205)(206)(207)(208)(209)(210)(211)(212)(213)(214)(215)(216). Thus, development of a coated surface that prevents bacterial colonization for a long time remains a challenge.…”

Section: Currently Used Approaches Do Not Specifically Target Biofilmmentioning

confidence: 99%

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

Lebeaux

Ghigo

Beloin

2014

Microbiol Mol Biol Rev

1,050

862

View full text Add to dashboard Cite

International audienceSurface-associated microbial communities, called biofilms, are present in all environments. Although biofilms play an important positive role in a variety of ecosystems, they also have many negative effects, including biofilm-related infections in medical settings. The ability of pathogenic biofilms to survive in the presence of high concentrations of antibiotics is called "recalcitrance" and is a characteristic property of the biofilm lifestyle, leading to treatment failure and infection recurrence. This review presents our current understanding of the molecular mechanisms of biofilm recalcitrance toward antibiotics and describes how recent progress has improved our capacity to design original and efficient strategies to prevent or eradicate biofilm-related infections

show abstract

“…Of these, only nitrofurazone-impregnated catheters and catheters with hydrophilic and/or silver alloyimpregnated coatings have reached the U.S. market; these have shown mixed results (29)(30)(31)(32)(33)35). However, a recent study by Pickard et al (36) found that neither silver alloy-nor nitrofurazonecoated catheters significantly reduced CAUTIs in a clinical study of patients with short-term catheterization, and the clinical data are currently considered insufficient to strongly recommend their use in standard practice (16).…”

mentioning

confidence: 99%

Bacteriophage-Mediated Control of a Two-Species Biofilm Formed by Microorganisms Causing Catheter-Associated Urinary Tract Infections in anIn VitroUrinary Catheter Model

Lehman

Donlan

2015

Antimicrob Agents Chemother

118

105

View full text Add to dashboard Cite

Microorganisms from a patient or their environment may colonize indwelling urinary catheters, forming biofilm communities on catheter surfaces and increasing patient morbidity and mortality. This study investigated the effect of pretreating hydrogelcoated silicone catheters with mixtures of Pseudomonas aeruginosa and Proteus mirabilis bacteriophages on the development of single-and two-species biofilms in a multiday continuous-flow in vitro model using artificial urine. Novel phages were purified from sewage, characterized, and screened for their abilities to reduce biofilm development by clinical isolates of their respective hosts. Our screening data showed that artificial urine medium (AUM) is a valid substitute for human urine for the purpose of evaluating uropathogen biofilm control by these bacteriophages. Defined phage cocktails targeting P. aeruginosa and P. mirabilis were designed based on the biofilm inhibition screens. Hydrogel-coated catheters were pretreated with one or both cocktails and challenged with approximately 1 ؋ 10 3 CFU/ml of the corresponding pathogen(s). The biofilm growth on the catheter surfaces in AUM was monitored over 72 to 96 h. Phage pretreatment reduced P. aeruginosa biofilm counts by 4 log 10 CFU/cm 2 (P < 0.01) and P. mirabilis biofilm counts by >2 log 10 CFU/cm 2 (P < 0.01) over 48 h. The presence of P. mirabilis was always associated with an increase in lumen pH from 7.5 to 9.5 and with eventual blockage of the reactor lines. The results of this study suggest that pretreatment of a hydrogel urinary catheter with a phage cocktail can significantly reduce mixed-species biofilm formation by clinically relevant bacteria.A recently reported survey of 183 acute care hospitals in 2011 found that approximately 9% of the health care-associated infections were catheter-associated urinary tract infections (CAUTIs) (1). The increases in patient morbidity, hospital stays, and costs of care for patients with CAUTIs are substantial (2, 3).Microorganisms may colonize indwelling urinary catheters and form extensive and often multispecies biofilm (4-8). The exact role of catheter-associated biofilms in CAUTI pathogenesis is poorly understood, but there is evidence that such biofilms play an important role as stable reservoirs of uropathogenic microorganisms that are resistant to antimicrobials (9-12) and difficult to eliminate even if the catheter is removed (13-15). Large reductions in CAUTI rates can be achieved by limiting catheterized patient days and by implementing good catheter care practices (16), but there is still substantial interest in developing urinary catheters that are highly resistant to bacterial colonization by virtue of an inherent property of the material itself or by impregnation or coating of the structural material with an antimicrobial or biological agent. Proposed strategies have included surface patterning (17, 18), novel polymers (19), instillation of catheter retention balloons with bactericidal chemicals (20, 21), bacterial interference (22, 23), and catheter coat...

show abstract

Antimicrobial catheters for reduction of symptomatic urinary tract infection in adults requiring short-term catheterisation in hospital: a multicentre randomised controlled trial

Abstract: UK National Institute for Health Research Health Technology Assessment Programme.

Cited by 219 publications

References 15 publications

A prospective interventional study to examine the effect of a silver alloy and hydrogel--coated catheter on the incidence of catheter-associated urinary tract infection

A prospective interventional study to examine the effect of a silver alloy and hydrogel--coated catheter on the incidence of catheter-associated urinary tract infection

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

Bacteriophage-Mediated Control of a Two-Species Biofilm Formed by Microorganisms Causing Catheter-Associated Urinary Tract Infections in anIn VitroUrinary Catheter Model

Contact Info

Product

Resources

About