Antimicrobial compounds from Eremophila serrulata

Ndi, Chi P.; Semple, Susan J.; Griesser, Hans J.; Pyke, Simon M.; Barton, Mary

doi:10.1016/j.phytochem.2007.05.039

Cited by 50 publications

(44 citation statements)

References 16 publications

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“…This compound showed antimicrobial activity against other Gram-positive bacteria including S. pyogenes and S. pneumoniae. [40] The ethanol extract of E. sturtii leaves as well as its ethyl acetate fraction exhibited antibacterial activity against S. aureus. Two novel serrulatane diterpenes were isolated, 3,8-dihydroxyserrulatic acid (114) and serrulatic acid (118), with the latter exhibiting the most potent bactericidal activity against S. aureus.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…[39] E. serrulata Ether extract (a) 9-methyl-3-(4-methyl-3-pentenyl)-2,3dihydronaphtho[1,8-bc]pyran-7,8-dione (b) 20-acetoxy-8-hydroxyserrulat-14-en-19-oic acid. (c) 8,20-dihydroxyserrulat-14-en-19-oic acid (d) 8,20diacetoxyserrulat-14-en-19-oic acid Antimicrobial activity against S. aureus [40] E. sturtii Ethanol crude extract 3,8-dihydroxyserrulatic acid Serrulatic acid…”

Section: E Maculatamentioning

confidence: 99%

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The genus Eremophila (Scrophulariaceae): an ethnobotanical, biological and phytochemical review

Singab

Youssef

Ashour

2013

Journal of Pharmacy and Pharmacology

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Objectives Eremophila (Scrophulariaceae) is an endemic Australian genus with 214 species, which is commonly known as Fuchsia bush, Emu bush or Poverty bush. Plants of this genus played an important role for the Australian Aborigines who used them widely for medicinal and ceremonial purposes. Many studies have been carried out on many species of this genus and have generated immense data about the chemical composition and corresponding biological activity of extracts and isolated secondary metabolites. Key findings Thorough phytochemical investigations of different Eremophila species have resulted in the isolation of more than 200 secondary metabolites of different classes with diterpenes as major constituents. Biological studies and traditional clinical practice demonstrated that Eremophila and its bioactive compounds possess various pharmacological properties. Plants were employed especially as a cardiotonic drug and also as potent anti-inflammatory, antimicrobial and antiviral agents. Summary Further investigations are required to explore other Eremophila species, to evaluate the different biological activities of either their extracts or the isolated compounds and the possible underlying modes of action.

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Section: Antimicrobial Activitymentioning

confidence: 99%

Section: E Maculatamentioning

confidence: 99%

The genus Eremophila (Scrophulariaceae): an ethnobotanical, biological and phytochemical review

Singab

Youssef

Ashour

2013

Journal of Pharmacy and Pharmacology

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“…Structural elucidation of antimicrobially active compounds isolated from several Eremophila plant species has led to the identifi cation of more than 10 diterpene compounds of the serrulatane class that possess activity in solution against gram -positive bacteria associated with biomedical device infections, including methicillin -resistant S. aureus . 98,99 Figure 6.6 shows the general serrulatane skeleton and the structures of representative serrulatanes with antibacterial activity. Active serrulatanes possess hydrophilic substituents such as − COOH, − OH, − OMe, or − OAc in one or both rings, with acetylation or methylation reducing activity.…”

Section: Experimental Antibioticsmentioning

confidence: 99%

Antimicrobial and Anti‐Inflammatory Intelligent Surfaces

Griesser

Hall

Jenkins

et al. 2012

Intelligent Surfaces in Biotechnology

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“…Diterpenes also display significant antimicrobial activity (Tatsimo et al, 2005;Kuzma et al, 2007;Ndi et al, 2007;Fukumoto et al, 2008;Porto et al, 2009a;Porto et al, 2009b;Carvalho et al, 2011;Andrade et al, 2011;Moreira et al, 2016;Moreti et al, 2017;Veneziani et al, 2017). Ambrosio et al (2004) isolated and identified diterpenes of the pimarane type from V. arenaria baker root extracts.…”

Section: Introductionmentioning

confidence: 99%

Diterpenes of the pimarane type isolated from Viguiera arenaria: Promising in vitro biological potential as therapeutic agents for endodontics

Marangoni¹,

Moraes²,

Utrera³

et al. 2018

J. Pharmacognosy Phytother.

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Viguiera arenaria, family Asteraceae, is a plant that contains diterpenoids, which make this species potentially applicable in endodontics. More specifically, V. arenaria contains diterpenes of the pimarane type, which display various classic biological activities. This study evaluates the antibiofilm activity, the time-kill curve, and the inhibitory concentration index of diterpenes of the pimarane type (entpimara-8(14),15-dien-19-oic acid, ent-8(14),15-pimaradien-3β-ol, and ent-8(14),15-pimaradien-3β-19-oic acid sodium salt, designated diterpenes I, II, and III, respectively) toward nine anaerobic bacteria commonly found in endodontic infections; this study also assesses the cytotoxic activity of these diterpenes against human fibroblasts. According to the antibiofilm assay, diterpenes I, II, and III inhibit at least 50% of all the bacteria. On the basis of the time-kill curve experiments, the behavior of these diterpenes depends on the tested bacteria, diterpene concentration, and microorganism sensitivity. Synergism of diterpenes I and II with chlorhexidine (CDH) was higher against P. gingivalis (clinical isolate) and Aggregatibacter actinomycetemcomitans (ATCC). As for diterpene III, synergism with CDH is higher against P. micros. As revealed by the XTT assay, none of the diterpenes of the pimarane type tested here are cytotoxic. Hence, diterpenes I, II, and III are promising biomolecules and may provide therapeutic solutions in the field of endodontics.

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Antimicrobial compounds from Eremophila serrulata

Cited by 50 publications

References 16 publications

The genus Eremophila (Scrophulariaceae): an ethnobotanical, biological and phytochemical review

The genus Eremophila (Scrophulariaceae): an ethnobotanical, biological and phytochemical review

Antimicrobial and Anti‐Inflammatory Intelligent Surfaces

Diterpenes of the pimarane type isolated from Viguiera arenaria: Promising in vitro biological potential as therapeutic agents for endodontics

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