Antimicrobial Diterpenes from Trigonostemon chinensis

Abstract

Five new diterpenes, trigonochinenes A-E (1-5), and two known ones, 3,4- seco-sonderianol (6) and 3,4- seco-sonderianic acid (7), were isolated from the aerial part of Trigonostemon chinensis. Compounds 1-4 possess a rare 3,4-seco-cleistanthanic skeleton, and compound 5 is a highly aromatized tetranorditerpene. Structures of these compounds were elucidated by spectroscopic analysis. The antimicrobial activities of compounds 1-7 were evaluated against a panel of bacteria and fungi.

Peroxy natural products

“…258 A rare 3,4-seco-cleistanthane hydroperoxide designated as trigonochinene C 428 with antimicrobial activity was isolated from the aerial parts of Trigonostemon chinensis. 259 Nine jatrophane hydroperoxides, amygdaloidins C 429 and E-L 430-437, have been isolated from the wood spurge, Euphorbia amygdaloides. 260 A methanol extract of Anisomeles indica afforded two cembrane hydroperoxides 4-methylene-5β-hydroperoxyovatodiolide 438 and 4α-Hydroperoxy-5-enovatodiolide 439, of which 439 showed inhibitory effects on antiplatelet aggregation induced by thrombin.…”

Antimycotic potential of a diterpenoid taxoquinone against <i>Candida</i> species isolated from <i>Metasequoia glyptostroboides</i>

“…Previous studies suggest that various terpenoid compounds of plant origin can be available for trials to control severe fungal infections caused by Candida species. These compounds may be applied in the same way against the pathogenic isolates of Candida species as alternative medicinal products where these pathogens have developed resistance against the specific fungicides (Sandven, 2000;Yin et al, 2008).…”

“…Candida species are getting serious worldwide due to several pathogenic disorders in human beings, although control measures are available, but limitedly effective (Yin et al, 2008). Hence, biologically active compounds of plant origin may be considered as an effective and alternative biological approach to develop new and novel types of antifungal agents for preventive treatment of serious fungal infections caused by pathogenic Candida species.…”

Discovery of structurally diverse and bioactive compounds from plant resources in China

“…More than 260 diterpenoids were obtained by our research group in the past years from the Euphorbia [72] , Trigonostemon [73][74][75][76][77][78][79] , Daphne [80] , Pseudolarix [81,82] , Siegesbeckia [83] , Sapium [84] , and Larix [85] genera. Among them, 122 were new compounds, and 4 possessed novel carbon scaffolds.…”