Antimicrobial effect of a drinking water additive comprising four organic acids on Campylobacter load in broilers and monitoring of bacterial susceptibility

Szott, Vanessa; Peh, Elisa; Friese, Anika; Roesler, Uwe; Kehrenberg, Corinna; Ploetz, Madeleine; Kittler, Sophie

doi:10.1016/j.psj.2022.102209

Cited by 10 publications

(23 citation statements)

References 55 publications

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“…This improved digestibility leads to an improvement in overall bird performance, which encourages the use of the OAs for growth, disease control, and economical advantages [9,11]. Lower pHs, when further investigated, have shown that harmful microbials cannot thrive in this environment in chickens [5,7,12] and meat ducks [9] due to microbiome changes reducing epithelial permeability [7]. Villus height and crypt depth measurements of the small intestine in various studies have also shown significant trends for improved nutrient digestion, resulting in improved mineral absorption and microflora populations [6,7,10].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Supplementation with Organic Acid and Oregano Oils in Drinking Water on Pekin Duck Growth and Welfare

Rocha,

Archer

2024

Poultry

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This study evaluated duck growth, health, and welfare in response to water supplementation with organic acid (OA) and oregano oils (OOs) in Pekin duck. The treatments used in this study included a control (CON) treatment with no water additives given, an OA treatment (ProPhorce Exclusive NC®), and an OO treatment (Nubiotic 4X Concentrate®). The OA and OO improved the feed conversion ratio (FCR) and body weight (BW) (p < 0.01) compared to the control (CON). Both OA and OO showed differences (p < 0.05) in villus height and crypt depth compared to the CON. But only OA showed an increase (p < 0.01) in villus height and villus height/crypt depth ratio. On D 35, the total plasma corticosterone levels, heterophil-to-lymphocyte ratios, and asymmetry scores for OA and OO were decreased (p < 0.05) compared to CON, indicating lower stress susceptibility. The pH levels of OA ceca and jejunum were lower (p < 0.05) compared to CON. Tibia breaking strength was increased (p = 0.02) for OA compared to CON, while no differences were found with OO (p > 0.05). In conclusion, these experiments indicate that OA and OO can be used to improve duck growth, feed efficiency, stress susceptibility, and bird welfare.

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Section: Introductionmentioning

confidence: 99%

The Effect of Supplementation with Organic Acid and Oregano Oils in Drinking Water on Pekin Duck Growth and Welfare

Rocha,

Archer

2024

Poultry

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“…However, data regarding potential anti-inflammatory features of organic acids in C. jejuni infection are rather scarce. Lately, researchers have focused on synergistic effects between organic acids or with other molecules, as it is hypothesized that the combination of distinct organic acids might enforce already existing characteristics such as antimicrobial and immunomodulatory properties ( Lourenço et al, 2018 ; Pelyuntha et al, 2022 ; Szott et al, 2022 ). Previously, our group investigated the anti-pathogenic and anti-inflammatory effects of the short chain fatty acid (SCFA) butyrate during C. jejuni infection in SAB IL-10 knockout mice ( Du et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Combination of organic acids benzoate, butyrate, caprylate, and sorbate provides a novel antibiotics-independent treatment option in the combat of acute campylobacteriosis

Foote²,

Mousavi³

et al. 2023

Front. Microbiol.

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IntroductionThe food-borne Gram-negative bacterial pathogen Campylobacter jejuni may cause the acute enterocolitis syndrome campylobacteriosis in infected humans. Given that human C. jejuni infections are rising globally which hold also true for resistance rates against antibiotic compounds such as macrolides and fluoroquinolones frequently prescribed for the treatment of severe infectious enteritis, novel antibiotics-independent therapeutic strategies are needed. Distinct organic acids are well known for their health-beneficial including anti-microbial and immunomodulatory properties. In our present study, we investigated potential pathogen-lowering and anti-inflammatory effects of benzoic acid, butyric acid, caprylic acid, and sorbic acid either alone or in combination during acute murine campylobacteriosis.MethodsTherefore, secondary abiotic IL-10–/– mice were perorally infected with C. jejuni strain 81–176 and subjected to a 4-day-course of respective organic acid treatment.Results and discussionOn day 6 post-infection, mice from the combination cohort displayed slightly lower pathogen loads in the duodenum, but neither in the stomach, ileum nor large intestine. Remarkably, the clinical outcome of C. jejuni induced acute enterocolitis was significantly improved after combined organic acid treatment when compared to the placebo control group. In support, the combinatory organic acid treatment dampened both, macroscopic and microscopic inflammatory sequelae of C. jejuni infection as indicated by less colonic shrinkage and less pronounced histopathological including apoptotic epithelial cell changes in the colon on day 6 post-infection. Furthermore, mice from the combination as compared to placebo cohort exhibited lower numbers of innate and adaptive immune cells such as neutrophilic granulocytes, macrophages, monocytes, and T lymphocytes in their colonic mucosa and lamina propria, respectively, which also held true for pro-inflammatory cytokine secretion in the large intestines and mesenteric lymph nodes. Notably, the anti-inflammatory effects were not restricted to the intestinal tract, but could also be observed systemically given pro-inflammatory mediator concentrations in C. jejuni infected mice from the combination organic acid treatment that were comparable to basal values. In conclusion, our in vivo study provides first evidence that an oral application of distinct organic acids in combination exhibits pronounced anti-inflammatory effects and hence, constitutes a promising novel antibiotics-independent therapeutic strategy in the combat of acute campylobacteriosis.

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“…Applying mitigation measures during primary poultry production can have a major impact on the entry of Campylobacter during slaughter and processing 9 .Organic acids, plant extracts, and bacteriophages are mitigation measures under discussion for Campylobacter reduction 7 . Organic acids are naturally derived organic compounds with acidic properties and approved for use in animal production [10][11][12][13] . Previous in vitro studies show that a combination of different organic acids has advantages over single administration, for example, the concentrations of the individual organic acids can be reduced in some combinations in which synergistic activities occur [14][15][16] .…”

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confidence: 99%

“…Previous in vitro studies show that a combination of different organic acids has advantages over single administration, for example, the concentrations of the individual organic acids can be reduced in some combinations in which synergistic activities occur [14][15][16] . However, only a few investigations have addressed the application of combined organic acids 11,17,18 . In the present study, we build on a systematically developed and tested organic acid blend 11,14 .Curcumin is a bioactive polyphenol, which is extracted from rhizomes of Curcuma longa 19 .…”

mentioning

confidence: 99%

“…However, only a few investigations have addressed the application of combined organic acids 11,17,18 . In the present study, we build on a systematically developed and tested organic acid blend 11,14 .Curcumin is a bioactive polyphenol, which is extracted from rhizomes of Curcuma longa 19 . Various studies demonstrated the pharmacologic properties of curcumin, such as antioxidant, anti-inflammatory, and antimicrobial effects [20][21][22][23] .…”

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confidence: 99%

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Investigating bacteriophages as a novel multiple-hurdle measure against Campylobacter: field trials in commercial broiler plants

Bogun,

Peh,

Meyer-Kühling

et al. 2024

Sci Rep

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Campylobacter mitigation along the food production chain is considered effective for minimizing the public health burden of human campylobacteriosis. This study is the first combining different measures in a multiple-hurdle approach, using drinking water additives and feed additives in single and combined application schemes in commercial broiler plants. Broiler chickens in the study groups were naturally contaminated with Campylobacter. Application of an organic acid blend via drinking water, consisting of sodium propionate, potassium sorbate, and sodium diacetate, resulted in significant reductions of up to 4.9 log10 CFU/mL in fecal samples and in cecal samples at slaughter. The application of a phage mixture, consisting of Fletchervirus phage NCTC 12673 and Firehammervirus phage vB_CcM-LmqsCPL1/1, resulted in reductions of up to 1.1 log10 CFU/mL in fecal samples 1 day after dosing. The sole administration of curcumin via feed resulted in small and inconsistent reductions. In the group receiving a combination of all tested measures, reductions of up to 1.1 log10 CFU/mL were observed. Based on the results of our field trials, it was shown that both the sole application and the combined application of mitigation measures in primary production can reduce the Campylobacter load in broiler chickens, while no synergism could be observed.

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Antimicrobial effect of a drinking water additive comprising four organic acids on Campylobacter load in broilers and monitoring of bacterial susceptibility

Cited by 10 publications

References 55 publications

The Effect of Supplementation with Organic Acid and Oregano Oils in Drinking Water on Pekin Duck Growth and Welfare

The Effect of Supplementation with Organic Acid and Oregano Oils in Drinking Water on Pekin Duck Growth and Welfare

Combination of organic acids benzoate, butyrate, caprylate, and sorbate provides a novel antibiotics-independent treatment option in the combat of acute campylobacteriosis

Investigating bacteriophages as a novel multiple-hurdle measure against Campylobacter: field trials in commercial broiler plants

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