Antimicrobial effect of chlorine dioxide gas against foodborne pathogens under differing conditions of relative humidity

Park, S.H.; Kang, Dong‐Hyun

doi:10.1016/j.lwt.2014.09.031

Cited by 56 publications

(23 citation statements)

References 28 publications

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“…Previously published studies showed that exposure dosage and RH are the main factors influencing the disinfection efficacy of CD gas (Jeng and Woodworth, 1990;Park and Kang, 2015a). We obtained similar results in our study: the log reductions of spores became greater with increasing exposure dosage or RH.…”

Section: Factors Influencing the Disinfection Efficacy Of CD Gassupporting

confidence: 90%

A pilot study on using chlorine dioxide gas for disinfection of gastrointestinal endoscopes

Hao

et al. 2016

J. Zhejiang Univ. Sci. B

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Abstract:Objectives: This pilot study of employing chlorine dioxide (CD) gas to disinfect gastrointestinal endoscopes was conducted to meet the expectations of many endoscopy units in China for a high-efficiency and low-cost disinfectant. Methods: An experimental prototype with an active circulation mode was designed to use CD gas to disinfect gastrointestinal endoscopes. One type of testing device composed of polytetrafluoroethylene (PTFE) tubes (2 m long, inner diameter 1 mm) and bacterial carrier containers was used to simulate the channel of the endoscope. PTFE bacterial carriers inoculated with Bacillus atrophaeus with or without organic burden were used to evaluate the sporicidal activity of CD gas. Factors including exposure dosage, relative humidity (RH), and flow rate (FR) influencing the disinfection effect of CD gas were investigated. Moreover, an autoptic disinfecting test on eight real gastrointestinal endoscopes after clinical use was performed using the experimental prototype. Results: RH, exposure dosage, organic burden, and the FR through the channel significantly (P<0.05) affected the disinfection efficacy of CD gas for a long and narrow lumen. The log reduction increased as FR decreased. Treatment with 4 mg/L CD gas for 30 min at 0.8 L/min FR and 75% RH, resulted in complete inactivation of spores. Furthermore, all eight endoscopes with a maximum colony-forming unit of 915 were completely disinfected. The cost was only 3 CNY (0.46 USD) for each endoscope. Conclusions: The methods and results reported in this study could provide a basis for further studies on using CD gas for the disinfection of endoscopes.

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Section: Factors Influencing the Disinfection Efficacy Of CD Gassupporting

confidence: 90%

A pilot study on using chlorine dioxide gas for disinfection of gastrointestinal endoscopes

Hao

et al. 2016

J. Zhejiang Univ. Sci. B

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“…Many studies have reported the potent oxidant and antimicrobial activity of chlorine dioxide in vitro. Recent reports have addressed concerns related to microbial decontamination of food by chlorine dioxide [6,9,18,19,20,21]. In these studies, chlorine dioxide was produced using various methods (e.g., 2% NaClO 2 with H 3 PO 4 , 4% Cl 2 with 80% NaClO 2, and by using an electrogenerator); the antimicrobial activity was more than 2% for 5–75 mg/L ClO 2 within 5–30 min.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety Evaluation of a Chlorine Dioxide Solution

Huang²,

Hsu³

et al. 2017

IJERPH

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In this study, a chlorine dioxide solution (UC-1) composed of chlorine dioxide was produced using an electrolytic method and subsequently purified using a membrane. UC-1 was determined to contain 2000 ppm of gaseous chlorine dioxide in water. The efficacy and safety of UC-1 were evaluated. The antimicrobial activity was more than 98.2% reduction when UC-1 concentrations were 5 and 20 ppm for bacteria and fungi, respectively. The half maximal inhibitory concentrations (IC50) of H1N1, influenza virus B/TW/71718/04, and EV71 were 84.65 ± 0.64, 95.91 ± 11.61, and 46.39 ± 1.97 ppm, respectively. A 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test revealed that the cell viability of mouse lung fibroblast L929 cells was 93.7% at a 200 ppm UC-1 concentration that is over that anticipated in routine use. Moreover, 50 ppm UC-1 showed no significant symptoms in a rabbit ocular irritation test. In an inhalation toxicity test, treatment with 20 ppm UC-1 for 24 h showed no abnormality and no mortality in clinical symptoms and normal functioning of the lung and other organs. A ClO2 concentration of up to 40 ppm in drinking water did not show any toxicity in a subchronic oral toxicity test. Herein, UC-1 showed favorable disinfection activity and a higher safety profile tendency than in previous reports.

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“…This considerable interaction could also verified by the nonlinear nature of the response surface (Figure 4b) and the respective contour plots (Figure 4a) (Yetilmezsoy et al, 2009). Several studies have also indicated that the combination of the ClO 2 gas concentration and RH represents a synergistic effect (Park and Kang, 2015;). This synergistic effect may be attributed to the following: Water vapor may condense onto the surface to surround the spores under high RH conditions (Pottage et al, 2012).…”

Section: Discussionmentioning

confidence: 58%

Response surface modeling for the inactivation ofBacillus subtilissubsp.nigerspores by chlorine dioxide gas in an enclosed space

Wang

et al. 2016

Journal of the Air & Waste Management Association

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Antimicrobial effect of chlorine dioxide gas against foodborne pathogens under differing conditions of relative humidity

Cited by 56 publications

References 28 publications

A pilot study on using chlorine dioxide gas for disinfection of gastrointestinal endoscopes

A pilot study on using chlorine dioxide gas for disinfection of gastrointestinal endoscopes

Efficacy and Safety Evaluation of a Chlorine Dioxide Solution

Response surface modeling for the inactivation ofBacillus subtilissubsp.nigerspores by chlorine dioxide gas in an enclosed space

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