Antimicrobial Effect of Polymer-Based Silver Nanoparticle Coated Pedicle Screws

Hazer, Derya Burcu; Şakar, Mustafa; Dere, Yelda; Altinkanat, Gulsen; Ziyal, Ibrahim M.; Hazer, Baki̇

doi:10.1097/brs.0000000000001223

Cited by 52 publications

(31 citation statements)

References 29 publications

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“…It can therefore be assumed that the formation of a biofilm in silver coating will be at least reduced, if not prevented. Hazer et al could also show this effect in the rabbit model [ 29 ]. A significant difference in the germ spectrum was not established between the two groups.…”

Section: Discussionmentioning

confidence: 96%

Silver-coated modular Megaendoprostheses in salvage revision arthroplasty after periimplant infection with extensive bone loss – a pilot study of 34 patients

Zajonz

Birke

Ghanem

et al. 2017

BMC Musculoskelet Disord

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BackgroundHip and knee replacements in patients with bone defects after infection correlates with high rates of reinfection. In this vulnerable patient population, the prevention of reinfection is to be considered superordinate to the functionality and defect bridging. The use of silver coating of aseptic implants as an infection prophylaxis is already proven; however, the significance of these coatings in septic reimplantation of large implants is still not sufficiently investigated.MethodsIn a retrospective analysis, 34 patients who have been treated with a modular mega-endoprosthesis after a cured bone infection of the lower limb (femur or tibia) have been evaluated. One group with 14 patients (NSCG: non silver- coated group) was supplied with the non silver- coated implants: MML München- Lübeck™ modular endoprosthesis system (AQ Implants, Ahrensburg, Germany) or MUTARS® Modular Universal Tumor And Revision System (Implantcast GmbH, Buxtehude, Germany). The other group with 20 patients (SCG: silver- coated group) was supplied with the silver- coated system of MUTARS®. In addition to the clinical findings and the patients’ histories, specifically the reinfection rates, the patients’ mobility was assessed using the New Mobility Score (NMS, by Parker and Palmer).ResultsThe median follow-up period was 72 months, ranging from 6 to 267 months. The dropout rate was 5.8%. The reinfection rate after healed reinfection in SCG was 40% (8/20), in NSCG 57% (8/14), p = 0.34; α =0.05. The time for reinfection was, on average, 14 months (1–72 months) in SCG and 8 months (1–48 months) in the NSCG (p = 0.61; α =0.05). The two groups showed no differences in the NMS.ConclusionWith this retrospective analysis, it can be determined that the rate of reinfection of modular mega-endoprostheses on the hip and knee joint after healed periprosthetic joint infection (PJI) can be reduced by the use of silver coated implants. The time until reinfection can also be delayed by utilizing silver coated implants. Due to the low number of cases of this highly specific patient population, no statistical significance could be determined. A positive effect, however, can be assumed through the use of silver coatings in mega-endoprostheses after an infectious situation.

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Section: Discussionmentioning

confidence: 96%

Silver-coated modular Megaendoprostheses in salvage revision arthroplasty after periimplant infection with extensive bone loss – a pilot study of 34 patients

Zajonz

Birke

Ghanem

et al. 2017

BMC Musculoskelet Disord

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“…The purpose of the selected coating parameters was to employ the bactericidal properties of silver, but to avoid possible negative consequences of the permanent implantation of scaffolds containing silver . While in the current study we did not analyze in vivo the presence of the silver coating following implantation into the bone residuum, the authors understand that this phenomenon needs to be evaluated in greater detail using objective methods (e.g., X‐ray spectrometry, EDS) . We plan to address this limitation of the current study in the near future.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of the temporary effect of physical vapor deposition silver coating on resistance to infection in transdermal skin and bone integrated pylon with deep porosity

et al. 2018

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Periprosthetic infection via skin-implant interface is a leading cause of failures and revisions in direct skeletal attachment of limb prostheses. Implants with deep porosity fabricated with skin and bone integrated pylons (SBIP) technology allow for skin ingrowth through the implant's structure creating natural barrier against infection. However, until the skin cells remodel in all pores of the implant, additional care is required to prevent from entering bacteria to the still nonoccupied pores. Temporary silver coating was evaluated in this work as a means to provide protection from infection immediately after implantation followed by dissolution of silver layer in few weeks. A sputtering coating with 1 µm thickness was selected to be sufficient for fighting infection until the deep ingrowth of skin in the porous structure of the pylon is completed. In vitro study showed less bacterial (Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa) growth on silver coated tablets compared to the control group. Analysis of cellular density of MG-63 cells, fibroblasts, and mesenchymal stem cells (MSCs) showed that silver coating did not inhibit the cell growth on the implants and did not affect cellular functional activity. The in vivo study did not show any postoperative complications during the 6-month observation period in the model of above-knee amputation in rabbits when SBIP implants, either silver-coated or untreated were inserted into the bone residuum. Three-phase scintigraphy demonstrated angiogenesis in the pores of the pylons. The findings suggest that a silver coating with well-chosen specifications can increase the safety of porous implants for direct skeletal attachment. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018.

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“…Recently, researchers developed a titanium pedicle screw coated with silver nanoparticles which could inhibit biofilm formation on the implanted screws in rabbits. 95 Nanotechnology-enabled infection control has demonstrated substantial promise to prevent acute postoperative infections in trauma and spinal implants in addition to joint replacements. 93…”

Section: Current Anti-infective Strategies In Orthopedic Surgerymentioning

confidence: 99%

Nanotechnology-enabled materials for hemostatic and anti-infection treatments in orthopedic surgery

Sun¹,

Lv²,

Bai³

et al. 2018

IJN

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The hemostatic and anti-infection treatments in the field of orthopedics are always the pivotal yet challenging topics. In the first part of this review, synthesized or naturally derived nanoscale agents and materials for hemostatic treatment in orthopedic surgery are introduced. The hemostatic mechanisms and the safety concerns of these nanotechnology-enabled materials are discussed. Beside the materials to meet hemostatic needs in orthopedic surgery, the need for antimicrobial or anti-infection strategy in orthopedic surgery also becomes urgent. Nanosilver and its derivatives have the most consistent anti-infective effect and thus high translational potential for clinical applications. In the second part, the factors affecting the antimicrobial effect of nanosilver and its application status are summarized. Finally, the status and translational potential of various nanotechnology-enabled materials and agents for hemostatic and anti-infective treatments in orthopedic surgery are discussed.

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Antimicrobial Effect of Polymer-Based Silver Nanoparticle Coated Pedicle Screws

Cited by 52 publications

References 29 publications

Silver-coated modular Megaendoprostheses in salvage revision arthroplasty after periimplant infection with extensive bone loss – a pilot study of 34 patients

Silver-coated modular Megaendoprostheses in salvage revision arthroplasty after periimplant infection with extensive bone loss – a pilot study of 34 patients

Evaluation of the temporary effect of physical vapor deposition silver coating on resistance to infection in transdermal skin and bone integrated pylon with deep porosity

Nanotechnology-enabled materials for hemostatic and anti-infection treatments in orthopedic surgery

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