Antimicrobial effect of silver nanoparticles (AgNPs) and their mechanism – a mini review

Kalwar, Kaleemullah; Shan, Dan

doi:10.1049/mnl.2017.0648

Cited by 98 publications

(60 citation statements)

References 118 publications

(113 reference statements)

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“…A number of compounds added to materials can reduce the risk of bacteria growing on the surface. The use of silver or copper nanoparticles causes the antimicrobial properties of biocomposites [ 10 , 11 , 12 ]. An alternative approach to reducing healthcare-associated pathogens is the use of ultraviolet irradiation [ 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Testing of Antimicrobial Activity of Composites of Unsaturated Polyester Resins with Wood Flour and Silver Nanoparticles

et al. 2021

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This paper presents the properties of the wood-resin composites. For improving their antibacterial character, silver nanoparticles were incorporated into their structures. The properties of the obtained materials were analyzed in vitro for their anti-biofilm potency in contact with aerobic Gram-positive Staphylococcus aureus and Staphylococcus epidermidis; and aerobic Gram-negative Escherichia coli and Pseudomonas aeruginosa. These pathogens are responsible for various infections, including those associated with healthcare. The effect of silver nanoparticles incorporation on mechanical and thermomechanical properties as well as gloss were investigated for the samples of composites before and after accelerating aging tests. The results show that bacteria can colonize in various wrinkles and cracks on the composites with wood flour but also the surface of the cross-linked unsaturated polyester resin. The addition of nanosilver causes the death of bacteria. It also positively influences mechanical and thermomechanical properties as well as gloss of the resin.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Testing of Antimicrobial Activity of Composites of Unsaturated Polyester Resins with Wood Flour and Silver Nanoparticles

et al. 2021

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“…Their small size and high surface area make them ideal candidates for drug delivery [8]. Silver, gold, copper and iron oxide nanoparticles have been widely used as potent therapeutic agents against bacteria due to their possible interaction with DNA, and inherent antibacterial properties [9–11]. However, at present there are only a few reports for the use of nanoparticles against free-living amoebae.…”

Section: Introductionmentioning

confidence: 99%

Cobalt nanoparticles as novel nanotherapeutics against Acanthamoeba castellanii

et al. 2019

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Background Species of Acanthamoeba are facultative pathogens which can cause sight threatening Acanthamoeba keratitis and a rare but deadly brain infection, granulomatous amoebic encephalitis. Due to conversion of Acanthamoeba trophozoites to resistant cyst stage, most drugs are found to be ineffective at preventing recurrence of infection. This study was designed to test the antiacanthamoebic effects of different cobalt nanoparticles (CoNPs) against trophozoites and cysts, as well as parasite-mediated host cell cytotoxicity. Methods Three different varieties of CoNPs were synthesized by utilizing hydrothermal and ultrasonication methods and were thoroughly characterized by X-ray diffraction and field emission scanning electron microscopy. Amoebicidal, encystation, excystation, and host cell cytopathogenicity assays were conducted to study the antiacanthamoebic effects of CoNPs. Results The results of the antimicrobial evaluation revealed that cobalt phosphate Co 3 (PO 4 ) 2 hexagonal microflakes, and 100 nm large cobalt hydroxide (Co(OH) 2 ) nanoflakes showed potent amoebicidal activity at 100 and 10 µg/ml against Acanthamoeba castellanii as compared to granular cobalt oxide (Co 3 O 4 ) of size 35–40 nm. Furthermore, encystation and excystation assays also showed consistent inhibition at 100 µg/ml. CoNPs also inhibited amoebae-mediated host cell cytotoxicity as determined by lactate dehydrogenase release without causing significant damage to human cells when treated alone. Conclusions To our knowledge, these findings determined, for the first time, the effects of composition, size and morphology of CoNPs against A. castellanii . Co 3 (PO 4 ) 2 hexagonal microflakes showed the most promising antiamoebic effects as compared to Co(OH) 2 nanoflakes and granular Co 3 O 4 . The results reported in the present study hold potential for the development of antiamoebic nanomedicine.

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“…Among colloidal solutions of the different metal nanoparticles (MNPs) the solutions of silver nanoparticles (AgNPs) have the widest application in different branches of the industry in particular in medicine [1–4], catalysis [1, 5, 6], the sensor systems [7–9] etc. It is well known that the functional properties of MNPs including AgNPs depend on their shape and size [10–13].…”

Section: Introductionmentioning

confidence: 99%

“…As it was shown on the example of the investigation of the formation of AgNPs [21, 23–25], the nature of the reducing agent and anions also has a significant role in nucleation which is based on the reaction (1). However, the most famous methods of the preparation of colloidal solutions of stabilised AgNPs which are based on the use of precursors, namely soluble silver salts and synthetic [26, 27] or natural origin [4, 8, 14, 25, 28–30] reductants, do not always provide the possibility to synthesise the nanoparticles of given size and shape. From this point of view, the electrochemical synthesis of AgNPs is promising and it is intensively studied in the last decade [31–40].…”

Section: Introductionmentioning

confidence: 99%