Antimicrobial effect of TiO2 nanotubes coating for dental implant

Capellato, Patrícia; Claro, Ana Paula Rosifini Alves; Silva, G.; Zavaglia, Cecília A. C.

doi:10.1016/j.dental.2018.08.043

Cited by 3 publications

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“…In previous studies, it was investigated the behavior of gram positive and negative bacteria on TiO 2 nanotubes. The nanometric surface also showed antibacterial activity compared to flat surfaces 54,55 . In opposition, another study applied efforts to dope hydroxyapatite with antimicrobial agents because it does not have an innate response for microbial formation, despite its abroad use for bone regeneration 32 .…”

Section: Resultsmentioning

confidence: 89%

Titanium-Tantalum Alloy Surface Modification by Hydroxyapatite Layer on TiO2 Nanotubes: Effect on Microbial Activity

et al. 2021

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One of the major health security challenges of the 21st century is the occurrence of microbial infections and bacterial complications that could affect 10 million people by 2050. On the biomaterial field, implant metallic currently replaces partial or total body parts and can fail to be integrated into the body due to infections. This study performs two combined surface modifications on Ti-30Ta alloy, in order to obtain an infection-resistance and osseointegration surface on metallic implants to be tested within bacterial biofilm. The Group 1 investigated surface modifications by the anodization process in the electrolyte glycerol + NH 4 F 0.25% at 30V-9 hours and annealed in 530°C (5°C/min). The Group 2 underwent the same process as Group 1 and, additionally, the samples were immersed in 0.3 M CaCl 2 and 0.5 M Na 2 HPO 4 solutions for hydroxyapatite growth. The substrate was characterized using scanning electron microscopy (SEM), X-ray diffractometer (XRD) and dynamic contact angle. S. epidermidis bacterial adhesion and biofilm formation. The results indicated that the Group 1 shows a higher antimicrobial activity, hydrophilic behavior and potential to be used for metallic implant applications. The Group 2 with the hydroxyapatite film coating did not have an improvement in the antimicrobial response.

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Section: Resultsmentioning

confidence: 89%

Titanium-Tantalum Alloy Surface Modification by Hydroxyapatite Layer on TiO2 Nanotubes: Effect on Microbial Activity

et al. 2021

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Optimization of Anodization Parameters in Ti-30Ta Alloy

Capellato

Sachs

Vasconcelos

et al. 2020

Metals

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The current metallic biomaterial still presents failures associated with the bulk alloy and the interface of material/human body. In previous studies, titanium alloy with tantalum showed the elastic modulus decrease in comparison with that of commercially pure (cp) titanium. In this study, surface modification on Ti-30Ta alloy was investigated. Titanium and tantalum were melted, homogenized, cold-worked by a rotary swaging process and solubilized. The anodization process was performed in electrolyte contained glycerol + NH4F 0.25% at 30 V using seven different durations—4 h, 5 h, 6 h, 7 h, 8 h, 9 h, and 10 h and annealed at 530 °C for 1 h. The surface topography was characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM) measurements, X-ray diffraction analysis (XRD), and contact angle. From the results, we conclude the time of anodization process influences the shape and morphology of the anodized layer. The 5 h-anodization process produced a smooth and porous surface. The 4-, 6-, 7-, 8-, 9-, and 10-h conditions showed nanotubes morphology. All surfaces are hydrophilic (<90°). Likewise, all the investigated conditions present anatase phase. So, this surface modification presents potential for biomedical application. However, more work needs to be done to better understand the influence of time on the anodization process.

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Influence of Annealing Temperature on Corrosion Resistance of TiO2 Nanotubes Grown on Ti–30Ta Alloy

Capellato

Sachs

Vilela

et al. 2020

Metals

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With little success, researchers has been searching for alloys with elements such as tantalum to improve the long-term life of implants. The Ti–30Ta alloy presents an elastic modulus E = 69 GPa that is close to that of bone (E = 17–25 GPa) than Ti cp (E = 105 GPa). In addition, nanostructure surface modification influences cell behavior and antimicrobial activity. So, this study investigates the corrosion behavior of surface modification by TiO2 nanotube grown on Ti–30Ta alloy after anodization process in the electrolyte glycerol + NH4F 0.25% at 30 V, for nine hours without annealing and annealed in 450 °C, 530 °C and 600 °C (5 °C/min). The electrochemical behavior was evaluated by three electrodes cell. The counter-electrode of graphite, reference-electrode of saturated calomel electrode and working-electrode at electrolyte of 0.15 M NaCl + 0.03 M NaF, with pH = 6 for 8000 s. The scanned region ranged from −0.8 V to values up to 3.5 V with a sweep rate 0.166 mV/s. Potentiodynamic polarization curves were obtained with a potentiostat. The sample was characterized by scanning electron microscopy (SEM) imaging, X-ray diffraction analysis (XRD) and wettability with a contact angle goniometer. We concludes from the obtained results that all treatment surfaces are hydrophilic (<90°). The surface covered with TiO2 nanotube crystallinity showed anatase phase after annealing at 450 °C, 530 °C and 600 °C; the exceptions were the anodized-without-annealing treatment and without-surface-modification alloys. The electrochemical behavior of the five groups investigated showed similar high resistance to corrosion solution under all conditions.

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Antimicrobial effect of TiO2 nanotubes coating for dental implant

Cited by 3 publications

References 0 publications

Titanium-Tantalum Alloy Surface Modification by Hydroxyapatite Layer on TiO2 Nanotubes: Effect on Microbial Activity

Titanium-Tantalum Alloy Surface Modification by Hydroxyapatite Layer on TiO2 Nanotubes: Effect on Microbial Activity

Optimization of Anodization Parameters in Ti-30Ta Alloy

Influence of Annealing Temperature on Corrosion Resistance of TiO2 Nanotubes Grown on Ti–30Ta Alloy

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