Antimicrobial effects of an NO-releasing poly(ethylene vinylacetate) coating on soft-tissue implants in vitro and in a murine model

Engelsman, Anton F.; Krom, Bastiaan P.; Busscher, Henk J.; Dam, Gooitzen M. van; Ploeg, Rutger J.; Mei, Henny C. van der

doi:10.1016/j.actbio.2009.01.041

Cited by 56 publications

(47 citation statements)

References 29 publications

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“…In a study by Engelsman et al, monofilament polypropylene mesh was coated with a low concentration NO-releasing carbon-based coating. The mesh showed significant bactericidal effect against S. aureus, E. coli, P. aeruginosa and coagulase-negative staphylococcus in vitro part of the study while such an effect could not be detected for subcutaneously implanted mesh in mice [104].…”

Section: Mesh Modificationsmentioning

confidence: 94%

“…These effects are the result of oxidative and nitrosative stress generated by reactive intermediates of nitric oxide, resulting in damage to DNA, proteins and cell membranes. Nitric oxide is metabolized very rapidly by human metabolism in order to prevent toxicity [104,105]. In a study by Engelsman et al, monofilament polypropylene mesh was coated with a low concentration NO-releasing carbon-based coating.…”

Section: Mesh Modificationsmentioning

confidence: 99%

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Innovative Modifications for Preventing Mesh Infections

Aydınuraz¹

2017

J Microb Biochem Technol

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Section: Mesh Modificationsmentioning

confidence: 94%

Section: Mesh Modificationsmentioning

confidence: 99%

Innovative Modifications for Preventing Mesh Infections

Aydınuraz¹

2017

J Microb Biochem Technol

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“…There are numerous NO-releasing coatings on biomaterials currently under investigation, many of which have demonstrated decreased incidence of biomaterial-associated infections. NO-releasing carbon-based coatings added to monofilament polypropylene meshes, as a means of reducing infectious complications after abdominal wall surgeries, had a significant bactericidal effect on in vitro biofilms of S. aureus and other pathogens (Engelsman et al 2009). Regev-Shoshani et al (2010 also presented a novel approach that creates an antiseptic barrier on urinary catheters by impregnating them with gaseous NO.…”

Section: Nitric Oxidementioning

confidence: 99%

Mini-review: Antimicrobial central venous catheters – recent advances and strategies

2011

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Central venous catheters (CVCs) nowadays constitute critical devices used in medical care, namely in intensive care units. However, CVCs also represent one of the indwelling medical devices with enhanced risk of nosocomial devicerelated infection. Catheter-related infections (CRIs) are a major cause of patient morbidity and mortality, often justifying premature catheter removal and an increase in costs and use of resources. Adhesion and subsequent biofilm formation on the surfaces of indwelling catheters is elemental to the onset of pathogenesis. Seeking the prevention of CVC colonisation and CRI, a variety of approaches have been studied, tested and, in some cases, already applied in clinical practice. This review looks at the current preventive strategies often used to decrease the risk of CRIs due to colonization and biofilm formation on catheter surfaces, as well as at the more recent approaches under investigation.

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“…12,13 This material could be adapted to each specialty, satisfying the needs of both the professional and the patient.…”

Section: Introductionmentioning

confidence: 99%

In vitro analysis of a local polymeric device as an alternative for systemic antibiotics in Dentistry

et al. 2017

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The development of a biodegradable material with antimicrobial properties for local applications is required in the prevention and treatment of infectious diseases. The objective of this study was to produce blends of poly-L-lactide acid (PLLA) synthetic polymer associated with several antimicrobials, as an alternative in the prevention and treatment of infections, as well as to evaluate its cytotoxicity, release of antimicrobials and inhibit bacteria growth. Blends of PLLA added with 20% Amoxicillin, Metronidazole, Clindamycin or Azithromicyn were used to produce Films (F) or Meshs (M) by casting and electrospinning methods, respectively. Standardized discs of the films and meshs were stored in buffer solutions (pH 5 or 7.4) and aliquots were analyzed by high performance chromatography (HPLC) during 168 hours. Cytotoxicity on human gingival fibroblasts was tested after 24, 48 and 72h by MTT reaction. The antimicrobial capacity was determined against P. gingivalis and S. pyogenes. The specimens were weighed after 3 and 6 months of storage for degradation analysis. SEM was performed to control interfaces and degradation. Antimicrobials presented a continuous and exponential drug release. Analysis showed that both M and F were able to inhibit S. pyogenes and P. gingivalis growth, indicating the release of active antimicrobial agents. The products were not toxic to the fibroblasts. Amoxicillin-film showed more degradation than PLLA at both pHs (p < 0.05), whereas Azithromycin-meshes were more degraded than PLLA at pH 7.4 (p < 0.05). PLLA association with antimicrobials is biocompatible and may represent a potential tool for the local delivery of antimicrobials.

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Antimicrobial effects of an NO-releasing poly(ethylene vinylacetate) coating on soft-tissue implants in vitro and in a murine model

Cited by 56 publications

References 29 publications

Innovative Modifications for Preventing Mesh Infections

Innovative Modifications for Preventing Mesh Infections

Mini-review: Antimicrobial central venous catheters – recent advances and strategies

In vitro analysis of a local polymeric device as an alternative for systemic antibiotics in Dentistry

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