Antimicrobial efficacy of a nitric oxide-releasing ampicillin conjugate catheter lock solution on clinically-isolated antibiotic-resistant bacteria

Abstract

Antibiotic lock therapy (ALT) is a standard clinical practice for treating bacteremia linked with catheter-related bloodstream infections (CRBSIs). However, this strategy frequently fails against multi-drug-resistant bacteria in clinical settings. In...

Engineering Nitric Oxide-Releasing Antimicrobial Dental Coating for Targeted Gingival Therapy

“…Unlike specific antibiotics that target distinct pathways in different bacteria types, NO’s multimechanistic and nonspecific action remains effective across all bacteria types . Notably, NO exhibits potent antibacterial effects against a wide range of bacteria including both antibiotic-resistant and susceptible bacteria without inducing NO resistance. , This surpasses the effectiveness of alternative antibacterial agents, such as gold nanoparticles and chlorhexidine, which are frequently integrated into dental floss for the management of periodontal infections. ,, Synthetic chemicals, such as chlorhexidine, may disrupt the natural oral microbiome equilibrium and have cytotoxic effects . Conversely, NO is a naturally found molecule responsible for several regulatory functions in oral health.…”

“… 30 Notably, NO exhibits potent antibacterial effects against a wide range of bacteria including both antibiotic-resistant and susceptible bacteria without inducing NO resistance. 62 , 63 This surpasses the effectiveness of alternative antibacterial agents, such as gold nanoparticles and chlorhexidine, which are frequently integrated into dental floss for the management of periodontal infections. 9 , 51 , 52 Synthetic chemicals, such as chlorhexidine, may disrupt the natural oral microbiome equilibrium and have cytotoxic effects.…”

Dielectric and Magnetic Composites of Fe3O4@APNs for Superior Microwave Thermal Effect

“…Chronic osteomyelitis with deep tissue infection could persist for several years or even be life-long and might be accompanied by severe cases of amputation and the risk of life-threatening systemic infection. , In clinical setting, postoperative anti-infection treatment is a common treatment for chronic osteomyelitis . However, due to the low penetration rate of antimicrobials into the bone tissue and the simultaneous broad-spectrum resistance associated with the strong pathogenic ability of methicillin-resistant Staphylococcus aureus (MRSA), a large dose of antibiotics is required to achieve the antibacterial effect. , Use of antibiotics in high doses produces a higher risk of adverse effects such as renal impairment and hyperthermia, while repeated use of antibiotics can cause drug resistance. − In response to drug resistance and the toxic side effects of antibiotic treatment, a new therapeutic method with synergistic antibacterial effects is an important focus in this field.…”