Antimicrobial Efficacy of Cinnamonum verum Essential Oil Alone and in Combination with Antibiotics and Other Essential Oils

Padalia, Hemali; Rathod, Tejas; Moteriya, Pooja; Chanda, Sumitra

doi:10.20546/ijcmas.2017.611.397

Cited by 11 publications

(6 citation statements)

References 16 publications

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“…As reported by several studies, cinnamon oil has a powerful antimicrobial effect due to deformation of the microbial cytoplasmic membrane [28][29][30] . In the present study, cinnamon oil showed the strongest antibacterial effect,with a significant difference (P-value <0.001) among the three E. coli groups (ESBL E. coli, AmpC E. coli and non-ESBL-AmpC E. coli), which agreed with several previous reports 22, 28,32,33 , however opposed by a study that showed no synergy 34 . The present study had the advantage of testing oil/antibiotic combinations against drug-resistant E-coli isolates from patients, as most of published reports tested ATCC drug-susceptible strains 15 .…”

Section: Discussionsupporting

confidence: 92%

Synergy of Herbal Oil Extracts/Antibiotic Combinations in Drug- Resistant Uropathogenic E. coli

Hassan¹,

Elnagdy²,

Taleb³

et al. 2020

J Pure Appl Microbiol

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Urinary tract infection (UTI) is the second most common infection worldwide and Escherichia coli (E.coli) is the chief causing pathogen. Antimicrobial resistance results into therapeutic failure. This study aimed to incrimination of E. coli as uropathogen harbouring cnf1 gene (necrotoxin virulence)and to detect the in vitro antimicrobial efficacy of several selected essential oil/antibiotic combinations against the isolated uropathogenic E. coli. Well diffusion method was used to determine the minimal inhibitory concentrations (MICs) to essential oils (EOs) individually. Broth micro-dilution method was used to determine the minimal inhibitory concentrations (MICs) to antibiotics and in combinations, to figure out the interactive efficacy of tested combinations. Necrotoxin cnf1 gene was detected by PCR assay. E.coli was detected at a rate of 40.6% of the isolated urinary pathogens and 47.8% showed ESBL production. In-vitro synergistic efficacy was only observed for cinnamon oil/gentamycin combination in 100% of selected 15 tested isolates (P-value <0.001). The cnf1 virulence gene was detected in 40% of tested isolates showing no significant correlation the conferred pattern of resistance among the E. coli isolates. Cinnamon/gentamycin combination against drug-resistant E-coli is promising and can pave the way for further clinical trials to formulate pharmacological combinations.

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Section: Discussionsupporting

confidence: 92%

Synergy of Herbal Oil Extracts/Antibiotic Combinations in Drug- Resistant Uropathogenic E. coli

Hassan¹,

Elnagdy²,

Taleb³

et al. 2020

J Pure Appl Microbiol

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“…Cinnamon is a natural component showing a wide range of pharmacological functions; among the biological properties assigned to the majority of compounds, we can cite the chemotypes rich in eugenol and benzyl benzoate, which have antifungal and antioxidant potential [ 18 ]. C. verum oil, especially rich in cinnamaldehyde, can act in synergism with antibiotics commercial to increase antimicrobial potential [ 15 ]. The cinnamaldehyde compound and its derivatives act as a high anti-carcinogenic agent [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

“…This species has received more attention in the last decades due to increasing scientific evidence on its potential medicinal and therapeutic value [ 9 ]. Among the most relevant biological activities are anticancer [ 9 ], antidiabetic [ 10 , 11 ], antioxidant, anticholinergic [ 12 ], anti-inflammatory [ 13 ], anti-human immunodeficiency virus (HIV) [ 14 ], antimicrobial [ 15 ], and cytotoxic activities [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Essential Oil Chemotypes and Genetic Variability of Cinnamomum verum Leaf Samples Commercialized and Cultivated in the Amazon

et al. 2022

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Cinnamomum verum (Lauraceae), also known as “true cinnamon” or “Ceylon cinnamon” has been widely used in traditional folk medicine and cuisine for a long time. The systematics of C. verum presents some difficulties due to genetic variation and morphological similarity between other Cinnamomum species. The present work aimed to find chemical and molecular markers of C. verum samples from the Amazon region of Brazil. The leaf EOs and the genetic material (DNA) were extracted from samples cultivated and commercial samples. The chemical composition of the essential oils from samples of C. verum cultivated (Cve1-Cve5) and commercial (Cve6-c-Cv9-c) was grouped by multivariate statistical analysis of Principal Component Analysis (PCA). The major compounds were rich in benzenoids and phenylpropanoids, such as eugenol (0.7–91.0%), benzyl benzoate (0.28–76.51%), (E)-cinnamyl acetate (0.36–32.1%), and (E)-cinnamaldehyde (1.0–19.73%). DNA barcodes were developed for phylogenetic analysis using the chloroplastic regions of the matK and rbcL genes, and psbA-trnH intergenic spacer. The psbA-trnH sequences provided greater diversity of nucleotides, and matK confirmed the identity of C. verum. The combination of DNA barcode and volatile profile was found to be an important tool for the discrimination of C. verum varieties and to examine the authenticity of industrial sources.

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“…Correlating these results, it can be observed that the major compound of cinnamon EO, cinnamaldehyde, has an inhibitory activity equivalent to EO, but it needs a higher concentration than cinnamon EO itself to exert bactericidal activity, which is not of economic and technological interest depending on the cost necessary for its isolation. Padalia et al (2017) investigated synergism between C. verum EO and antibiotics (ampicillin, gentamicin, chloramphenicol, penicillin-G, and tetracycline) using the disk diffusion method against S. aureus (ATCC 29737). The antibiotic disks were impregnated with 20µL of EO diluted in ethanol.…”

Section: Discussionmentioning

confidence: 99%

“…The cell wall of Gram-positive bacteria, on the other hand, has an extensive layer of peptideoglycan, the presence of theoretical acids and proteins, which facilitate the entry of hydrophobic molecules through the cell wall into the cytoplasm. In turn, the phenolic compounds present in EOs, can benefit from this cellular structure to obtain greater antimicrobial activity in cells (Padalia et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of cinnamon (Cinnamomum verum) essential oil and cinnamaldehyde against Staphylococcus aureus

Franciscato

Sekine

Sakai

et al. 2022

RSD

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The aim of this study was to compare the antimicrobial activity of the essential oil (EO) of cinnamon (Cinnamomum verum) and its major compound cinnamaldehyde against Staphylococcus aureus (ATCC 14458) and bacteria isolated from mastitic milk. Cinnamon EO was chemically characterized by gas chromatography/mass spectrometry (GC-MS). The Minimum Inhibitory Concentration (MIC) and the Minimum Bactericidal Concentration (MBC) of cinnamon EO and cinnamaldehyde were determined, as well as the effects of MIC and CBM on S. aureus cells, visualized by Scanning Electron Microscopy (SEM) and Microscopy Transmission Electronics (TEM). A synergistic evaluation of the EO of cinnamon and cinnamaldehyde with conventional antimicrobials was also performed. Results: The substance cis-cinnamaldehyde (58.7%) was identified as the major component of cinnamon EO. The MIC values determined against all tested strains ranged between 0.8 and 1.6 mg.mL-1. SEM and TEM images (post-treatment with cinnamon EO and cinnamaldehyde) showed coarse-shaped S. aureus cells with residues adhered to the cell wall and irregular and irregular regions at the points of cell division. Conclusion: Both cinnamon EO and cinnamaldehyde showed undetermined antimicrobial activity combined with conventional antimicrobials, which brings the prospect of their ability to intensify the antimicrobial action of veterinary drugs used in the treatment of mastitis caused by multidrug-resistant bacteria.

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Antimicrobial Efficacy of Cinnamonum verum Essential Oil Alone and in Combination with Antibiotics and Other Essential Oils

Cited by 11 publications

References 16 publications

Synergy of Herbal Oil Extracts/Antibiotic Combinations in Drug- Resistant Uropathogenic E. coli

Synergy of Herbal Oil Extracts/Antibiotic Combinations in Drug- Resistant Uropathogenic E. coli

Essential Oil Chemotypes and Genetic Variability of Cinnamomum verum Leaf Samples Commercialized and Cultivated in the Amazon

Antimicrobial activity of cinnamon (Cinnamomum verum) essential oil and cinnamaldehyde against Staphylococcus aureus

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