Antimicrobial Efficacy of Silver Nanoparticles as Root Canal Irrigant’s: A Systematic Review

Bhandi, Shilpa; Mehta, Dhoom Singh; Mashyakhy, Mohammed; Chohan, Hitesh; Testarelli, Luca; Thomas, Jacob; Dhillon, Harnoor; Raj, A. Thirumal; Balaji, Thodur Madapusi; Varadarajan, Saranya; Patil, Shankargouda

doi:10.3390/jcm10061152

Cited by 20 publications

(14 citation statements)

References 42 publications

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“…What more, due to antibacterial effect these materials may be useful for various biomedical application, i.e. as antimicrobial and disinfect agent, or to prepare the antiseptic layers 85 – 87 . Simultaneously, the same nanomaterial, depends on the concentration used, could be a great platform for targeted drug delivery, as well as to combat with cancer cells 88 , 89 .…”

Section: Resultsmentioning

confidence: 99%

Noncytotoxic silver nanoparticles as a new antimicrobial strategy

Skóra

Krajewska

Nowak

et al. 2021

Sci Rep

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Drug-resistance of bacteria is an ongoing problem in hospital treatment. The main mechanism of bacterial virulency in human infections is based on their adhesion ability and biofilm formation. Many approaches have been invented to overcome this problem, i.e. treatment with antibacterial biomolecules, which have some limitations e.g. enzymatic degradation and short shelf stability. Silver nanoparticles (AgNPs) may be alternative to these strategies due to their unique and high antibacterial properties. Herein, we report on yeast Saccharomyces cerevisiae extracellular-based synthesis of AgNPs. Transmission electron microscopy (TEM) revealed the morphology and structure of the metallic nanoparticles, which showed a uniform distribution and good colloid stability, measured by hydrodynamic light scattering (DLS). The energy dispersive X-ray spectroscopy (EDS) of NPs confirms the presence of silver and showed that sulfur-rich compounds act as a capping agent being adsorbed on the surface of AgNPs. Antimicrobial tests showed that AgNPs inhibit the bacteria growth, while have no impact on fungi growth. Moreover, tested NPs was characterized by high inhibitory potential of bacteria biofilm formation but also eradication of established biofilms. The cytotoxic effect of the NPs on four mammalian normal and cancer cell lines was tested through the metabolic activity, cell viability and wound-healing assays. Last, but not least, ability to deep penetration of the silver colloid to the root canal was imaged by scanning electron microscopy (SEM) to show its potential as the material for root-end filling.

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Section: Resultsmentioning

confidence: 99%

Noncytotoxic silver nanoparticles as a new antimicrobial strategy

Skóra

Krajewska

Nowak

et al. 2021

Sci Rep

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“…NaOCl is the current gold standard for root canal chemical disinfection [ 48 ]. The antibacterial effects of irrigants, e.g., NaOCl, CHX, and AgNPs depend on their concentration [ 13 ], contact time, and contact surface area [ 49 ]. Ioannidis et al (2019) reported the efficacy of AgNPs synthesized on an aqueous matrix of graphene oxide (GO) in the elimination of microorganisms and biofilm in an infected tooth model.…”

Section: Application Of Agnps In Endodonticsmentioning

confidence: 99%

Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review

et al. 2023

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The efficient elimination of microorganisms and their byproducts from infected root canals is compromised by the limitations in conventional root canal disinfection strategies and antimicrobials. Silver nanoparticles (AgNPs) are advantageous for root canal disinfection, mainly due to their wide-spectrum anti-microbial activity. Compared to other commonly used nanoparticulate antibacterials, AgNPs have acceptable antibacterial properties and relatively low cytotoxicity. Owing to their nano-scale, AgNPs penetrate deeper into the complexities of the root canal systems and dentinal tubules, as well as enhancing the antibacterial properties of endodontic irrigants and sealers. AgNPs gradually increase the dentin hardness in endodontically treated teeth and promote antibacterial properties when used as a carrier for intracanal medication. The unique properties of AgNPs make them an ideal additive for different endodontic biomaterials. However, the possible side effects of AgNPs, such as cytotoxicity and tooth discoloration potential, merits further research.

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“…Silver ions taken in the cell can cause malfunction of respiratory enzymes, causing responsive oxygen groups to form and adenosine triphosphate production to be disrupted. Direct denaturation of DNA and ribosomes can also be caused by silver ions [55]. Since it successfully dissolved E. faecalis biofilm and removed the bacteria from infected dentinal tubules, the Ag NP solution is an effective root canal irrigant [30].…”

Section: Ag Nps Used In Endodonticsmentioning

confidence: 99%

Antimicrobial Properties of Silver Nitrate Nanoparticle and Its Application in Endodontics and Dentistry: A Review of Literature

Thangavelu

Adil

Arshad

et al. 2021

Journal of Nanomaterials

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Background. The silver nanoparticles (Ag NPs) are the most acceptable and excellent nanotechnology-based product among all metallic nanoparticles (noble metals). They are novel in terms of good conductivity, catalytic, chemical stability, and most significant anti-inflammatory and antiviral activities. Aim. This review is aimed at understanding the synthesis, mechanism, and applications of Ag NPs in dentistry and their qualities to aid clinicians and researchers. Materials and Methods. A electronic search for literature was performed on the Google Scholar, PubMed, EMBASE, and Web of Science databases for related articles using multiple keywords. The keywords used were antimicrobial properties, mechanism of action, and current uses of Ag NPs in dentistry. The search was limited to articles published in the English language; no deadline was set for publications. Results. About 185 articles were considered relevant to the reported research out of 6420 electronic search results. Only the publications that were required were received after all abstracts were assessed for relevance. After a final electronic and manual search, roughly 47 research publications were found to be helpful in this study. Conclusion. The Ag NPs, unlike other biomaterials used in dentistry, have unique biological features and could be used in endodontics, restorative dentistry, periodontology, prosthetic dentistry, implantology, and oral malignancies, because of their antimicrobial, antifungal, and antiviral effects.

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Antimicrobial Efficacy of Silver Nanoparticles as Root Canal Irrigant’s: A Systematic Review

Cited by 20 publications

References 42 publications

Noncytotoxic silver nanoparticles as a new antimicrobial strategy

Noncytotoxic silver nanoparticles as a new antimicrobial strategy

Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review

Antimicrobial Properties of Silver Nitrate Nanoparticle and Its Application in Endodontics and Dentistry: A Review of Literature

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