Antimicrobial electrospun membranes of chitosan/poly(ethylene oxide) incorporating poly(hexamethylene biguanide) hydrochloride

Chlorhexidine gluconate or polyhexamethylene biguanide disc dressing to reduce the incidence of central-line-associated bloodstream infection: a feasibility randomized controlled trial (the CLABSI trial)

“…The disc has been shown to reduce biofilms in wounds 12 and reduce wound pain and wound size. 13 More importantly, PHMB has been shown to inhibit the growth of Staphylococcus aureus 14 , a common and serious pathogen in CLABSI. To date, there are no randomised controlled trials (RCTs) comparing the effectiveness of the PHMB disc with other products to reduce CLABSI; nor has the CHG disc dressing been tested in head-to-head studies with any other antimicrobial dressing.…”

Bioactive Applications for Electrospun Fibers

“…66 Intrinsically (or modified) biocidal polymers have been also explored by modifying the polymer backbone creating, for example, quaternary ammonium moieties 67,68 or co-electrospinning with polymeric antiseptics. 69 The grafting of styrene/maleic anhydride copolymers with poly(propylene glycol) monoamine (Jeffamine TM M-600) or 5-amino-8-hydroxyquinoline was explored as covalent post-processing of nanofibrous mats for antimicrobial activity. 70 Coaxial electrospinning can be used to prepare fibers from two separate solutions minimizing the interaction with the organic solvents used to dissolve polymers, but it can also be used to process difficult to spin polymers.…”

Chitosan as an Advanced Healthcare Material

“…A chitosan ethylene co-polymer (methyl acrylate and vinyl acetate) synthesized by Massouda et al was found to be eff ective against E. coli, Salmonella enterica and L. monocytogenes making it a strong candidate for antimicrobial packaging [149]. Dilamian et al produced electrospun membranes of chitosan/poly(ethylene oxide) in the presence of the broad spectrum antiseptic poly(hexamethylene biguanide) hydrochloride [150]. Th ese nanofi bres inhibited the growth of E. coli and S. aureus making these fi bres good candidates for biomaterials [150].…”

“…Dilamian et al produced electrospun membranes of chitosan/poly(ethylene oxide) in the presence of the broad spectrum antiseptic poly(hexamethylene biguanide) hydrochloride [150]. Th ese nanofi bres inhibited the growth of E. coli and S. aureus making these fi bres good candidates for biomaterials [150]. Similarly, Fouda and co-workers synthesized carboxymethyl chitosan/poly(ethylene oxide) nanofi bres embedded with Ag nanoparticles [151].…”