Antimicrobial electrospun nanofibers of cellulose acetate and polyester urethane composite for wound dressing

Liu, Xin; Lin, Tong; Gao, Yuan; Xu, Zhiguang; Huang, Chen; Yao, Gang; Jiang, Linlin; Tang, Yanwei; Wang, Xungai

doi:10.1002/jbm.b.32724

Cited by 190 publications

(98 citation statements)

References 26 publications

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“…For pharmaceutical applications, electrospun polymer-based fibers have been investigated for providing different types of controlled drug release profiles, such as immediate, pulsatile, delayed, sustained, and biphasic releases (7)(8)(9)(10). Among them, sustained drug release is gaining considerable attention as a method of administering and maintaining desired drug concentrations in the blood within a specified therapeutic window, or in target tissues within a desired duration of drug delivery (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Drug-Loaded Zein Nanofibers Prepared Using a Modified Coaxial Electrospinning Process

Huang

Zou

et al. 2013

AAPS PharmSciTech

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Abstract. This study investigated the preparation of drug-loaded fibers using a modified coaxial electrospinning process, in which only unspinnable solvent was used as sheath fluid. With zein/ibuprofen (IBU) co-dissolving solution and N, N-dimethylformamide as core and sheath fluids, respectively, the drug-loaded zein fibers could be generated continuously and smoothly without any clogging of the spinneret. Field emission scanning electron microscopy and transmission electron microscopy observations demonstrated that the fibers had ribbon morphology with a smooth surface. Their average diameters were 0.94±0.34 and 0.67±0.21 μm when the sheath-to-core flow rate ratios were taken as 0.11 and 0.25, respectively. X-ray diffraction and differential scanning calorimetry verified that IBU was in an amorphous state in all fiber composites. Fourier transform infrared spectra showed that zein had good compatibility with IBU owing to hydrogen bonding. In vitro dissolution tests showed that all the fibers could provide sustained drug release files via a typical Fickian diffusion mechanism. The modified coaxial electrospinning process reported here can expand the capability of electrospinning in generating fibers and provides a new manner for developing novel drug delivery systems.

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Section: Introductionmentioning

confidence: 99%

Drug-Loaded Zein Nanofibers Prepared Using a Modified Coaxial Electrospinning Process

Huang

Zou

et al. 2013

AAPS PharmSciTech

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“…In fact, the high effectiveness has been related to a novel mechanism of action based on the interaction of PHMB with nucleic acids that led to co-precipitation. At low bacteriostatic concentrations, the damage caused by this interaction could be tolerable and the antibacterial effect would be due to disruption of the cell membrane, as usually expected [33]. However, because the binding between PHMB and DNA is highly cooperative, a slightly higher drug dose can cause massive perturbation of DNA function and/or precipitation leading to cell death.…”

Section: Antibacterial Assays Of Biguanide Loaded 1l6 Scaffoldsmentioning

confidence: 90%

New poly(ester urea) derived from l-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes

Díaz

Valle

Tugushi

et al. 2015

Materials Science and Engineering: C

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Electrospun scaffolds from an amino acid containing poly(ester urea) (PEU) were developed as promising materials in the biomedical field and specifically in tissue engineering applications. The selected poly(ester urea) was obtained with a high yield and molecular weight by reaction of phosgene with a bis(α-aminoacyl)-α,ω-dioldiester monomer. The polymer having L-leucine, 1,6-hexanediol and carbonic acid units had a semicrystalline character and relatively high glass transition and melting temperatures. Furthermore it was highly soluble in most organic solvents, an interesting feature that facilitated the electrospinning process and the effective incorporation of drugs with bactericidal activity (e.g. biguanide derivatives such as clorhexidine and polyhexamethylenebiguanide) and enzymes (e.g. α-chymotrypsin) that accelerated the degradation process. Continuous micro/nanofibers were obtained under a wide range of processing conditions, being diameters of electrospun fibers dependent on the drug and solvent used. Poly(ester urea) samples were degradable in media containing lipases and proteinases but the degradation rate was highly dependent on the surface area, being specifically greater for scaffolds with respect to films. The high hydrophobicity of new scaffolds had repercussions on enzymatic degradability since different weight loss rates were found depending on how samples were exposed to the medium (e.g. forced or non-forced immersion). New scaffolds were biocompatible, as demonstrated by adhesion and proliferation assays performed with fibroblast and epithelial cells.

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“…wound dressing [230], porous matrices (scaffolds) for tissue engineering purposes, to support cells and promote their proliferation [231]. Multi-component, heterogeneous polymeric systems, blends [232]- [234], micro- [235] and nano-composites [236], play an important role addressing such complex expectations, as the properties of these can Table 6.…”

Section: Biosourced Polymers Blends and Compositesmentioning

confidence: 99%

Recent Strategies for the Development of Biosourced-Monomers, Oligomers and Polymers-Based Materials: A Review with an Innovation and a Bigger Data Focus

Rebouillat¹,

Pla²

2016

JBNB

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After setting the ground of the quantum innovation potential of biosourced entities and outlining the inventive spectrum of adjacent technologies that can derive from those, the current review highlights, with the support of Bigger Data approaches, and a fairly large number of articles, more than 250 and 10,000 patents, the following. It covers an overview of biosourced chemicals and materials, mainly biomonomers, biooligomers and biopolymers; these are produced today in a way that allows reducing the fossil resources depletion and dependency, and obtaining environmentallyfriendlier goods in a leaner energy consuming society. A process with a realistic productivity is underlined thanks to the implementation of recent and specifically effective processes where engineered microorganisms are capable to convert natural non-fossil goods, at industrial scale, into fuels and useful high-value chemicals in good yield. Those processes, further detailed, integrate: metabolic engineering involving 1) system biology, 2) synthetic biology and 3) evolutionary engineering. They enable acceptable production yield and productivity, meet the targeted chemical profiles, minimize the consumption of inputs, reduce the production of by-products and further diminish the overall operation costs. As generally admitted the properties of most natural occurring biopolymers (e.g., starch, poly (lactic acid), PHAs.) are often inferior to those of the polymers derived from petroleum; blends and composites, exhibiting improved properties, are now successfully produced. Specific attention is paid to these aspects. Then further evidence is provided to support the important potential and role of products deriving from the biomass in general. The need to en- ter into the era of Bigger Data, to grow and increase the awareness and multidimensional role and opportunity of biosourcing serves as a conclusion and future prospects. Although providing a large reference database, this review is largely initiatory, therefore not mimicking previous classic reviews but putting them in a multiplying synergistic prospective.

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Antimicrobial electrospun nanofibers of cellulose acetate and polyester urethane composite for wound dressing

Cited by 190 publications

References 26 publications

Drug-Loaded Zein Nanofibers Prepared Using a Modified Coaxial Electrospinning Process

Drug-Loaded Zein Nanofibers Prepared Using a Modified Coaxial Electrospinning Process

New poly(ester urea) derived from l-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes

Recent Strategies for the Development of Biosourced-Monomers, Oligomers and Polymers-Based Materials: A Review with an Innovation and a Bigger Data Focus

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