Antimicrobial gastrodin derivatives isolated from Bacopa procumbens

González-Cortazar, Manasés; López-Gayou, Valentín; Tortoriello, Jaime; Domínguez-Mendoza, Blanca Eda; Ríos-Cortés, Ada María; Delgado-Macuil, R.; Hernández-Beteta, Elías E.; Blé-González, Ever A.; Zamilpa, Alejandro

doi:10.1016/j.phytol.2019.03.005

Cited by 8 publications

(7 citation statements)

References 11 publications

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“…The same compound was identified in the aqueous fraction in the present study. Additionally, Gonzalez-Cortazar et al (2019) documented the presence of shikimic acid derivatives [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization of Polyphenolic Compounds from Bacopa procumbens and Their Effects on Wound-Healing Process

et al. 2022

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Wounds represent a medical problem that contributes importantly to patient morbidity and to healthcare costs in several pathologies. In Hidalgo, Mexico, the Bacopa procumbens plant has been traditionally used for wound-healing care for several generations; in vitro and in vivo experiments were designed to evaluate the effects of bioactive compounds obtained from a B. procumbens aqueous fraction and to determine the key pathways involved in wound regeneration. Bioactive compounds were characterized by HPLC/QTOF-MS, and proliferation, migration, adhesion, and differentiation studies were conducted on NIH/3T3 fibroblasts. Polyphenolic compounds from Bacopa procumbens (PB) regulated proliferation and cell adhesion; enhanced migration, reducing the artificial scratch area; and modulated cell differentiation. PB compounds were included in a hydrogel for topical administration in a rat excision wound model. Histological, histochemical, and mechanical analyses showed that PB treatment accelerates wound closure in at least 48 h and reduces inflammation, increasing cell proliferation and deposition and organization of collagen at earlier times. These changes resulted in the formation of a scar with better tensile properties. Immunohistochemistry and RT-PCR molecular analyses demonstrated that treatment induces (i) overexpression of transforming growth factor beta (TGF-β) and (ii) the phosphorylation of Smad2/3 and ERK1/2, suggesting the central role of some PB compounds to enhance wound healing, modulating TGF-β activation.

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Section: Discussionmentioning

confidence: 99%

Characterization of Polyphenolic Compounds from Bacopa procumbens and Their Effects on Wound-Healing Process

et al. 2022

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“…Greenm. (Scrophulariaceae) aerial parts collected from Mexico was rich in this compound [58] . The distribution of gastrodin in certain plants, especially those belonging to Orchidaceae, suggested its potential use in the chemotaxonomical classification of these plants.…”

Section: Source Of Gastrodinmentioning

confidence: 99%

“…Spectrometric (HRFAB‐MS) and spectroscopic ( 1 H‐NMR, 13 C‐NMR, 1 H− 1 H COSY, HSQC, HMBC), analyses were used for the identification of gastrodin from the aerial parts of Bacopa procumbens (Mill.) Greenm., [58] as well as from the stem, leaves, and roots of Datura tatula [53,65]…”

Section: Extraction Purification and Isolation Of Gastrodinmentioning

confidence: 99%

Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

El Menyiy,

Elouafy,

Moubachir

et al. 2024

Chemistry & Biodiversity

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Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti‐inflammatory, antioxidant, anti‐apoptotic, and anti‐tumor effects, gastrodin stands out as a multifaceted therapeutic agent. Notably, it has demonstrated efficacy in protecting against neuronal damage and enhancing cognitive function in animal models of Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Additionally, gastrodin showcases immunomodulatory effects by mitigating inflammation and suppressing the expression of inflammatory cytokines. Its cytotoxic activity involves the inhibition of angiogenesis, suppression of tumor growth, and induction of apoptosis. This comprehensive review seeks to elucidate the myriad potential effects of Gastrodin, delving into the intricate molecular mechanisms underpinning its pharmacological properties. The findings underscore the therapeutic potential of gastrodin in addressing various conditions linked to neuroinflammation and cancer.

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“…Los nombres comunes o vulgares dependen de la lengua nativa, de la comunidad en donde se ubican y de cómo aprecian los grupos humanos a esas especies. En este sentido, las personas entrevistadas conocen a B. procumbens con el nombre popular de metatera, oreja de ratón y un entrevistado mencionó el nombre de trencilla; los nombres anteriores ya han sido reportados por otros autores (Standley y Williams, 1973;González-Cortázar et al, 2019). Al parecer existe confusión en los nombres comunes con que se identifica a B. procumbens, pues en otros estudios se le ha referido como hierba golondrina.…”

Section: Características De La Especieunclassified

“…Algunos de los usos de B. procumbens han sido corroborados científicamente, en el caso de la cicatrización, Hidalgo (2010) comprobó que el extracto acuaetanólico de la planta estimula los fibroblastos de ratón en las primeras fases de cicatrización. De igual manera, González-Cortázar et al (2019) demostraron que los compuestos procumgastrodina A, B y C, obtenidos del extracto acuaetanólico de las partes aéreas de B. procumbens muestran actividad antimicrobiana. Considerando que esta especie vegetal ha sido evaluada científicamente, demostrando su actividad en el tratamiento de heridas y su efecto antimicrobiano y que actualmente, existe una pérdida importante del conocimiento tradicional, debido a la rápida urbanización y el apego a la medicina moderna que ha sido considerada como la medicina oficial (Bermúdez, Oliveira y Velázquez, 2005;Pereyra-Elías y Fuentes, 2012).…”

Section: Introductionunclassified

Conocimiento tradicional sobre Bacopa procumbens (Mill.) Small en Huasca de Ocampo, Hidalgo, México

et al. 2023

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Objetivo: Identificar el conocimiento sobre el uso tradicional de Bacopa procumbens que conservan los pobladores del municipio de Huasca de Ocampo, Hidalgo, México. Metodología: El estudio se basó en una entrevista estructurada aplicada a 26 informantes, mediante un muestreo por conveniencia. Se realizó el análisis descriptivo de la información por medio de frecuencias y un análisis multivariado de correspondencias múltiples. Resultados: El conocimiento tradicional de esta planta se concentra en las amas de casa con edad entre 40 y 50 años; este conocimiento fue trasmitido por familiares, el uso tradicional que le dan a la especie B. procumbens es medicinal y se usa para disminuir o aliviar el dolor de estómago, sanar heridas, calmar el dolor de muelas, calmar el dolor de riñón, eliminar la hinchazón y fiebre. La planta es recolectada en el campo, solo en la cantidad que será usada, lo que puede ayudar en parte a la conservación del recurso, aunque debe prevenirse la sobre explotación. Limitaciones: Existen pocas personas que conocen la planta y sus propiedades. Conclusiones: El conocimiento tradicional de la planta se centra en mujeres amas de casa, la forma más común de uso es hervida y se aplica principalmente para dolor de estómago, y otros problemas de salud.

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Antimicrobial gastrodin derivatives isolated from Bacopa procumbens

Cited by 8 publications

References 11 publications

Characterization of Polyphenolic Compounds from Bacopa procumbens and Their Effects on Wound-Healing Process

Characterization of Polyphenolic Compounds from Bacopa procumbens and Their Effects on Wound-Healing Process

Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

Conocimiento tradicional sobre Bacopa procumbens (Mill.) Small en Huasca de Ocampo, Hidalgo, México

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