Antimicrobial, hemolytic and thrombolytic activities of some new N-substituted-2-({5-[(1E,3E)F-4-(1,3-benzodioxol- 5-yl)-1,3-butadienyl]-1,3,4-oxadiazol-2-yl}sulfanyl) propanamides

Yasir, Ammar; Jahangir, Muhammad; Ur-Rehman, Aziz; Ishtiaq, Saiqa; Shahid, Muhammad

doi:10.4314/tjpr.v16i8.30

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Based on the results of the chemical shifts in NMR spectroscopy of three purified substances and previous studies, scopoletin, gallic acid, and piperic acid were determined [ 26 , 27 , 28 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening and Evaluation of Antioxidant Properties and Antimicrobial Activity against Xanthomonas axonopodis of Euphorbia tirucalli Extracts in Binh Thuan Province, Vietnam

Cường

Thinh

et al. 2021

Molecules

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Euphorbia tirucalli is a medicine plant possessing many bioactive properties. This paper focused on phytochemical screening (alkaloid, flavonoid, saponin, tannin, and anthraquinone), quantification of polyphenol and flavonoids, and activating evaluation of antioxidants and antimicrobial properties against Xanthomonas axonopodis of different extracts from Euphorbia tirucalli grown in Binh Thuan, Vietnam. The best activity fraction was used for purification and determining bioactive ingredients. The results showed that the phytochemical study revealed the presence of alkaloids, flavonoids, tannins, and terpenoids in the ethyl acetate fraction. Saponin and anthraquinone did not present in all extracts. The content of polyphenol and flavonoid of Euphorbia tirucalli stem was in the range of 16.65–106.32 mg EqAG/g and 97.97–450.83 μg QE/g. The ethyl acetate fraction showed higher amounts of polyphenol and flavonoids and antimicrobial activity against X. axonopodis than other fractions. The antioxidant (SC50) activity of Euphorbia tirucalli stem was in the range of 12.91 ± 0.70 and 528.33 ± 25.15 μg/mL. At concentrations of 5.0 and 7.5 mg/mL, the diameter of inhibition of the ethyl acetate fraction was 14.33 ± 0.76 mm and 17.87 ± 0.57 mm, respectively. The MIC (minimum inhibitory concentration) was 0.156 mg/mL. Scopoletin, gallic acid, and piperic acid got MICs corresponding to 78, 312, and 312 μg/mL, respectively. Scopoletin, gallic acid, and piperic acid were found in the ethyl acetate fraction of Euphorbia tirucalli and exhibited the treatment of citrus bacteria canker and plant diseases.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Screening and Evaluation of Antioxidant Properties and Antimicrobial Activity against Xanthomonas axonopodis of Euphorbia tirucalli Extracts in Binh Thuan Province, Vietnam

Cường

Thinh

et al. 2021

Molecules

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“…Notably, these strains included Escherichia coli and Pseudomonas aeruginosa, outperforming the effects of ciprofloxacin [20]. Yasir et al (2017) reported that propenamide exhibited robust inhibition against Bacillus subtilis and Escherichia coli, displaying zone of inhibition measurements of 16 mm for both bacterial strains [21].…”

Section: Discussionmentioning

confidence: 99%

Impact of Solidago virgaurea Extract on Biofilm Formation for ESBL-Pseudomonas aeruginosa: An In Vitro Model Study

Abdulkareem,

Alalwani,

Ahmed

et al. 2023

Pharmaceuticals

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The increasing disparity between antimicrobial resistance (AMR) and the development of new antimicrobials continues to pose a significant global health concern. However, plant extracts have shown promise in combating this issue either through their inherent antimicrobial activity or by serving as potential reservoirs of effective antimicrobial compounds. These compounds have the ability to target pathogenic biofilms and inhibit the production of extended-spectrum β -lactamases (ESBLs). However, there is limited research available on the antibacterial properties of goldenrod extract. Thus, the objective of this study was to investigate the impact of S. virgaurea (SV) extract on the viability and ability to form biofilms of ESBL-Pseudomonas aeruginosa (P. aeruginosa). A cross-sectional study was conducted from August 2022 to March 2023. The broth microdilution method was employed to determine the minimum inhibitory concentration (MIC) of the (SV) extract. Subsequently, the minimum bactericidal concentration (MBC) was determined based on the MIC values obtained. The antibiotic susceptibility of bacteria was evaluated using the Kirby disk diffusion assay and an Antimicrobial Susceptibility Testing (AST) card in conjunction with the Vitek-2 compact system. Biofilm formation was evaluated using Congo red and a 96-well Elisa plate, while the presence of extended-spectrum β-lactamases (ESBLs) was estimated by measuring the reduction of nitrocefin at a wavelength of 390 nm. In addition, treatment of biofilm and ESBL activity with SV extract using 96-well Elisa plate and nitrocefin hydrolyzing, respectively. The resistance rates of P. aeruginosa isolates to the tested antibiotics were as follows: Levofloxacin 33%, Ciprofloxacin 40%, Amikacin 49%, Meropenem 50%, Cefepime 70%, Ceftazidime 75%, Cefotaxime 85%, Piperacillin-Tazobactam 90%, Amoxiclav 97%, Ampicillin 99%, Ceftriaxone 100%. The prevalence of MDR-P. aeruginosa, XDR-P. aeruginosa, PDR-P. aeruginosa and non-MDR-PA were 40% (n = 40), 7% (n = 7), 3% (n = 3) and 50% (n = 50), respectively. From the GC–MS results, it was observed that the presence of Octadecane, Clioquinol, Glycerol tricaprylate, hexadecanoic acid, cis-13-octadecenoic acid, oleic acid and Propanamide were the major components in the Solidago extract. In the determination of plant crude extracts, the values ranged between 0.25 and 64 mg/mL against bacteria. The resulting activity of the extract showed a significant statistical relationship at a p-value ≤ 0.01 against ESBL production and biofilm formation in P. aeruginosa. The S. virgaurea extract exhibited effectiveness in inhibiting biofilm formation and combating P. aeruginosa strains that produce extended-spectrum β-lactamases (ESBLs).

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“…The spectral data were compared with the reported data of these compounds and found to be identical. 25,26 Interestingly, the absence of band at 1632.3 cm -1 in FTIR spectra which corresponded to the amide group of the piperine (1) confirms the complete conversion of piperine to piperic acid. Analgesic activity.…”

Section: Isolation and Purification Of Piperinementioning

confidence: 98%

Isolation, Chemical Modification and In vivo Pharmacological Screening of Piperine and its Derivatives

Tasneem,

Saha,

Spriha

et al. 2024

Dhaka Univ. J. Pharm. Sci

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Piperine (1) extracted from black pepper was transformed into its derivatives piperic acid (2) and piperonal (3) with good yields (69-76%). Animal models were used to examine the compounds' in vivo peripheral as well as central analgesic and anti-inflammatory effects. In the peripheral analgesic experiment, compound 2 displayed remarkable action having writhing inhibition by 78% at 50 mg/kg dose, superior to that of 1 (74% writhing inhibition) when administered at the same dose and compared with standard diclofenac sodium (85%). Concerning central analgesic efficacy, piperonal outperformed compounds 1 and 2 at 25 mg/kg dose, with % tail-flick elongation times of 194%, 178%, and 178% at 30, 60, and 90 min, respectively. Conversely, at 50 mg/kg dose, piperic acid exhibited the highest activity, demonstrating % tail-flick elongation times of 231%, 213%, and 206% at 30, 60, and 90 min, respectively, as compared to the standard morphine (278%, 247%, and 160%) in the same duration. In anti-inflammatory property evaluation, piperonal portrayed outstanding effects with paw edema inhibitions of 57%, 66%, 76%, and 81%, respectively from 1st hour onwards, compared to standard aceclofenac (61%, 72%, 78%, and 89%) and parent compound piperine (20%, 34%, 51%, and 60%). This study suggests that piperine derivatives could act as promising leads for future drug development. Dhaka Univ. J. Pharm. Sci. 23(1): 13-22, 2024 (June)

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Antimicrobial, hemolytic and thrombolytic activities of some new N-substituted-2-({5-[(1E,3E)F-4-(1,3-benzodioxol- 5-yl)-1,3-butadienyl]-1,3,4-oxadiazol-2-yl}sulfanyl) propanamides

Abstract: Purpose: To synthesize and evaluate the bioactivity of some N-substituted-2-({5-[(1E,3E)-4-(1,3-benzodioxol-5-yl)-1,3-butadienyl]-1,3,4-oxadiazol-2-yl}sulfanyl)propanamides (9a-o)

Cited by 3 publications

References 8 publications

Phytochemical Screening and Evaluation of Antioxidant Properties and Antimicrobial Activity against Xanthomonas axonopodis of Euphorbia tirucalli Extracts in Binh Thuan Province, Vietnam

Phytochemical Screening and Evaluation of Antioxidant Properties and Antimicrobial Activity against Xanthomonas axonopodis of Euphorbia tirucalli Extracts in Binh Thuan Province, Vietnam

Impact of Solidago virgaurea Extract on Biofilm Formation for ESBL-Pseudomonas aeruginosa: An In Vitro Model Study

Isolation, Chemical Modification and In vivo Pharmacological Screening of Piperine and its Derivatives

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