Antimicrobial Histones and DNA Traps in Invertebrate Immunity

Poirier, Aurore; Schmitt, Paulina; Rosa, Rafael Diego; Vanhove, Audrey S.; Kieffer‐Jaquinod, Sylvie; Rubio, Tristan; Charrière, Guillaume M.; Destoumieux-Garzón, Delphine

doi:10.1074/jbc.m114.576546

Cited by 90 publications

(90 citation statements)

References 37 publications

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“…ETs have now been described in deuterostomes [81] and protostomes, including species of Ecdysozoa (insects [82], crustaceans [83]) and Lophotrochozoa (molluscs [84]). This process is triggered by infection and/or tissue damage.…”

Section: (C) Shrimp Amps Encrypted In Multifunctional Proteins (I) Hamentioning

confidence: 99%

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Antimicrobial peptides in marine invertebrate health and disease

Destoumieux-Garzón

Rosa

Schmitt

et al. 2016

Phil. Trans. R. Soc. B

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120

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One contribution of 13 to a theme issue 'Evolutionary ecology of arthropod antimicrobial peptides'. Aquaculture contributes more than one-third of the animal protein from marine sources worldwide. A significant proportion of aquaculture products are derived from marine protostomes that are commonly referred to as 'marine invertebrates'. Among them, penaeid shrimp (Ecdysozosoa, Arthropoda) and bivalve molluscs (Lophotrochozoa, Mollusca) are economically important. Mass rearing of arthropods and molluscs causes problems with pathogens in aquatic ecosystems that are exploited by humans. Remarkably, species of corals (Cnidaria) living in non-exploited ecosystems also suffer from devastating infectious diseases that display intriguing similarities with those affecting farmed animals. Infectious diseases affecting wild and farmed animals that are present in marine environments are predicted to increase in the future. This paper summarizes the role of the main pathogens and their interaction with host immunity, with a specific focus on antimicrobial peptides (AMPs) and pathogen resistance against AMPs. We provide a detailed review of penaeid shrimp AMPs and their role at the interface between the host and its resident/pathogenic microbiota. We also briefly describe the relevance of marine invertebrate AMPs in an applied context. This article is part of the themed issue 'Evolutionary ecology of arthropod antimicrobial peptides'.

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Section: (C) Shrimp Amps Encrypted In Multifunctional Proteins (I) Hamentioning

confidence: 99%

“…This process is triggered by infection and/or tissue damage. ROS production is a signal that triggers ET formation in mammals [85] and lophotrochozoans [84]. In shrimp, haemocytes also release ETs in response to ROS inducers [83].…”

Section: (C) Shrimp Amps Encrypted In Multifunctional Proteins (I) Hamentioning

confidence: 99%

Antimicrobial peptides in marine invertebrate health and disease

Destoumieux-Garzón

Rosa

Schmitt

et al. 2016

Phil. Trans. R. Soc. B

Self Cite

120

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“…2009) and ETosis (Robb et al 2014). The production of ROS in STX-treated hemocytes was therefore measured over the course of 2 h and compared to ROS production in hemocytes exposed to zymosan, a reagent that induces a strong oxidative burst in oyster hemocytes (Poirier et al 2014). In contrast to zymosan, STX did not promote formation of detectable levels of ROS in hemocytes over a 2 h period, suggesting that the STXinduced death of C. gigas hemocytes is not triggered by ROS (Fig.…”

Section: Saxitoxin Does Not Induce Reactive Oxygen Species (Ros) Prodmentioning

confidence: 99%

“…Thus, apoptosis plays an important role in mollusc immunity (Sokolova 2009) and, more generally, in invertebrate immunity (Sokolova 2009;Terahara and Takahashi 2008;Hughes et al 2010;Zhang et al 2011). Hemocytes from bivalve molluscs also respond to infection and damage through additional cell death processes such as ETosis, which leads to the extracellular release of antimicrobial DNA traps (Poirier et al 2014;Robb et al 2014).…”

Section: Introductionmentioning

confidence: 99%

The paralytic shellfish toxin, saxitoxin, enters the cytoplasm and induces apoptosis of oyster immune cells through a caspase-dependent pathway

et al. 2017

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. HIGHLIGHTS-Saxitoxin (STX) appeared to spread throughout the cytoplasm of Crassostrea gigas hemocytes.-STX induces a caspase-dependent apoptosis death of hemocytes that does not depend on ROS production.-GTX5, which is present in large amounts in A. catenella, was found to be the most toxic derivate against oyster hemocytes.-Hyalinocytes were found to be a hemocyte population highly responsive to this toxic stress. Abstract:Exposure of the toxin-producing dinoflagellate Alexandrium catenella (A. catenella) was previously demonstrated to cause apoptosis of hemocytes in the oyster species Crassostrea gigas. In this work, a coumarin-labeled saxitoxin appeared to spread throughout the cytoplasm of the hemocytes. PSTs, including saxitoxin, were also shown to be directly responsible for inducing apoptosis in hemocytes, a process dependent on caspase activation and independent of reactive oxygen species (

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“…NET formation is evolutionarily conserved within the kingdoms of animals and plants and has been described in different mammalian species [1, 6, 29-31], birds [32], fish [31, 33], invertebrates [34, 35], and plants that protect their root tips against fungal infections with extracellular DNA [36]. …”

Section: Structure and Generation Of Neutrophil Extracellular Trapsmentioning

confidence: 99%

Neutrophil Extracellular Traps in the Second Decade

2018

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Nearly 15 years after the first description of neutrophil extracellular traps (NETs), our knowledge concerning this structure has expanded considerably. Initially, NETs were considered solely an elaborate function of the innate immune system to combat invading microorganisms. Successively it became clear that NETs have farther-reaching capabilities. They are involved in a series of pathophysiological mechanisms ranging from inflammation to thrombosis where they fulfill essential functions when produced at the right site and the right time but can have a serious impact when generation or clearance of NETs is inadequately controlled. This review provides a concise overview on the far-reaching functions of NETs in health and disease.

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Antimicrobial Histones and DNA Traps in Invertebrate Immunity

Cited by 90 publications

References 37 publications

Antimicrobial peptides in marine invertebrate health and disease

Antimicrobial peptides in marine invertebrate health and disease

The paralytic shellfish toxin, saxitoxin, enters the cytoplasm and induces apoptosis of oyster immune cells through a caspase-dependent pathway

Neutrophil Extracellular Traps in the Second Decade

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