Antimicrobial magnetic nanoparticles based-therapies for controlling infectious diseases

Rodrigues, Gisele Regina; López-Abarrategui, Carlos; Gómez, Inés de la Serna; Dias, Simoni Campos; Otero‐González, Anselmo J.; Franco, Octávio Luiz

doi:10.1016/j.ijpharm.2018.11.043

Cited by 101 publications

(71 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of microscopic observations of 48 h C. tropicalis biofilm shown in Figure 5 confirm the reduction of biofilm growth in the presence of preparation B, with the addition of MNP@Au or MNP@NH2 in comparison to unmodified saliva substitute B. It is established that three major mechanisms of nanomaterials are responsible for their antimicrobial properties, including membrane damage and cellular uptake; releasing toxic metals, which can react with macromolecules, causing a loss of their function, and in effect restricting grow or killing microbes; and generating reactive oxygen species (ROS), which cause DNA, RNA, and proteins damage [42]. Many recent studies indicated that magnetic nanoparticles can produce reactive oxygen species (ROS), which play a major role in various cellular pathways, via the Fenton and Haber-Weiss reaction [43].…”

Section: Resultsmentioning

confidence: 99%

“…This is in agreement with previously published studies that indicated that the coated systems displayed negligible ROS generation compared to uncoated nanoparticles. However, this is one part of their mode of action which determines their antimicrobial effect [42]. Our previously It is established that three major mechanisms of nanomaterials are responsible for their antimicrobial properties, including membrane damage and cellular uptake; releasing toxic metals, which can react with macromolecules, causing a loss of their function, and in effect restricting grow or killing microbes; and generating reactive oxygen species (ROS), which cause DNA, RNA, and proteins damage [42].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

Niemirowicz-Laskowska

Mystkowska

Łysik

et al. 2020

IJMS

View full text Add to dashboard Cite

Saliva plays a crucial role in oral cavity. In addition to its buffering and moisturizing properties, saliva fulfills many biofunctional requirements, including antibacterial activity that is essential to assure proper oral microbiota growth. Due to numerous extra- and intra-systemic factors, there are many disorders of its secretion, leading to oral dryness. Saliva substitutes used in such situations must meet many demands. This study was design to evaluate the effect of core-shell magnetic nanoparticles (MNPs) adding (gold-coated and aminosilane-coated nanoparticles NPs) on antimicrobial (microorganism adhesion, biofilm formation), rheological (viscosity, viscoelasticity) and physicochemical (pH, surface tension, conductivity) properties of three commercially available saliva formulations. Upon the addition of NPs (20 µg/mL), antibacterial activity of artificial saliva was found to increase against tested microorganisms by 20% to 50%. NPs, especially gold-coated ones, decrease the adhesion of Gram-positive and fungal cells by 65% and Gram-negative bacteria cells by 45%. Moreover, the addition of NPs strengthened the antimicrobial properties of tested artificial saliva, without influencing their rheological and physicochemical properties, which stay within the range characterizing the natural saliva collected from healthy subjects.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

Niemirowicz-Laskowska

Mystkowska

Łysik

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Nanomaterials can show antimicrobial activity via cell membrane damage, releasing toxic metals (which can react with proteins, leading to a loss in protein), and damaging DNA, RNA, and proteins via reactive oxygen species generation. These mechanisms conduce to inhibition or killing of the microorganisms [103].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…In this context, IOMNPs can contribute to improving antimicrobial treatments by targeting specific and hard-to-reach sites where pathogens are harbored. Moreover, they can optimize physicochemical characteristics, enabling the clinical use of new antimicrobial agents, or their administration using more convenient routes [103].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Bruschi

Toledo

2019

Magnetochemistry

View full text Add to dashboard Cite

Advances of nanotechnology led to the development of nanoparticulate systems with many advantages due to their unique physicochemical properties. The use of iron-oxide magnetic nanoparticles (IOMNPs) in pharmaceutical areas increased in the last few decades. This article reviews the conceptual information about iron oxides, magnetic nanoparticles, methods of IOMNP synthesis, properties useful for pharmaceutical applications, advantages and disadvantages, strategies for nanoparticle assemblies, and uses in the production of drug delivery, hyperthermia, theranostics, photodynamic therapy, and as an antimicrobial. The encapsulation, coating, or dispersion of IOMNPs with biocompatible material(s) can avoid the aggregation, biodegradation, and alterations from the original state and also enable entrapping the bioactive agent on the particle via adsorption or covalent attachment. IOMNPs show great potential for target drug delivery, improving the therapy as a consequence of a higher drug effect using lower concentrations, thus reducing side effects and toxicity. Different methodologies allow IOMNP synthesis, resulting in different structures, sizes, dispersions, and surface modifications. These advantages support their utilization in pharmaceutical applications, and getting suitable drug release control on the target tissues could be beneficial in several clinical situations, such as infections, inflammations, and cancer. However, more toxicological clinical investigations about IOMNPs are necessary.

show abstract

“…24 Among the most promising of the new antimicrobial agents' metal oxide nanoparticles have been shown to have high potential antibacterial activity in a large number of studies. [25][26][27][28] Different researchers have indicated that Al 2 O 3 contamination with other antioxidant metals improves photocatalytic activity and stability in α-Al 2 O 3 structural phase, [29][30][31] and leads to shifted emission peaks toward visible light, in addition to the presence of an auxiliary species, which can be effective in reducing the time of complete elimination of bacteria in the presence of ultraviolet light. 32,33 Nanocomposites with the use of ultrafine particles have wide applications in antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

Eco-Friendly and Systematic Study for Synthesis of La3+/α-Al2O3 Nanoparticles: Antibacterial Activity Against Pathogenic Microbial Strains

Moshafi

Ranjbar

Ilbeigi

2019

IJN

View full text Add to dashboard Cite

Purpose: In this study, for the first time, new nanoparticles of La 3+ /α-Al 2 O 3 were synthesized with the ultrasonic-assisted hydrothermal method in the presence of honey as an ecofriendly and natural reagent. Methods: The as-synthesized La 3+ /α-Al 2 O 3 nanoparticles were characterized using scanning electron microscopy (SEM), transition electron microscopy (TEM), X-ray diffraction spectroscopy (XRD), energy dispersive X-ray (EDX), UV-visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR) techniques. In this work, we report optimum conditions to synthesize La 3+ /α-Al 2 O 3 nanoparticles as novel material and as a candidate for antibacterial activity in antibacterial drugs. Results and Conclusion: The XRD and SEM micrograph results demonstrate the formation of pure La 3+ /α-Al 2 O 3 nanoparticles with a particle size in the range of 30-80 nm. The synthesis parameters were systematically examined using analysis of variance (ANOVA) through 2k −1 factorial design, and the factors were an assay for product optimization. Various factors such as hydrothermal time, temperature, ultrasound irradiation and interaction between these factors were investigated on the product size of the products. To investigate antibacterial activity of the La 3+ /α-Al 2 O 3 nanoparticles with the minimum inhibitory concentration (MIC) method, different dilutions of nanoparticles as 64,32,16,8,4, 2, 1 and 0.5 μg/mL were dissolved in dimethyl sulfoxide and diluted using distilled water and added to the Mueller-Hinton agar medium containing Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Serratia marcescens as gram-negative bacteria and Bacillus subtilis, Staphylococcus aureus, S. epidermidis and Micrococcus luteus as gram-positive bacteria.

show abstract

Antimicrobial magnetic nanoparticles based-therapies for controlling infectious diseases

Cited by 101 publications

References 128 publications

Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

<p>Eco-Friendly and Systematic Study for Synthesis of La<sup>3+</sup>/α-Al<sub>2</sub>O<sub>3</sub> Nanoparticles: Antibacterial Activity Against Pathogenic Microbial Strains</p>

Contact Info

Product

Resources

About