Antimicrobial mechanisms of biomaterials: from macro to nano

Roy, Shounak; Sarkhel, Sanchita; Bisht, Deepali; Hanumantharao, Samerender Nagam; Rao, Smitha; Jaiswal, Amit

doi:10.1039/d2bm00472k

Cited by 36 publications

(37 citation statements)

References 260 publications

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“…As the design of biomaterials in combination with AMPs has shown excellent potential for in vivo applications, this review focused on evaluating biomaterial-based AMP therapies. [138] With the development of advanced biomaterials (nanoparticles, chitosan, porous materials, and polymers) coupled with novel AMPs designed with promising bactericidal properties, AMP-based biomaterial therapies offer significant advantages for the treatment of bacterial infections. [139] Compared with single peptides, AMPs that incorporate biomaterials achieve slow release, provide effective local concentrations, reduce off-target effects and toxicity, improve the stability and activity of the AMPs, and modulate the efficacy of the local microenvironment.…”

Section: Discussionmentioning

confidence: 99%

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Advances of Antimicrobial Peptide‐Based Biomaterials for the Treatment of Bacterial Infections

Lai

Shan

2023

Advanced Science

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Owing to the increase in multidrug-resistant bacterial isolates in hospitals globally and the lack of truly effective antimicrobial agents, antibiotic resistant bacterial infections have increased substantially. There is thus an urgent need to develop new antimicrobial drugs and their related formulations. In recent years, natural antimicrobial peptides (AMPs), AMP optimization, self-assembled AMPs, AMP hydrogels, and biomaterial-assisted delivery of AMPs have shown great potential in the treatment of bacterial infections. In this review, it is focused on the development prospects and shortcomings of various AMP-based biomaterials for treating animal model infections, such as abdominal, skin, and eye infections. It is hoped that this review will inspire further innovations in the design of AMP-based biomaterials for the treatment of bacterial infections and accelerate their commercialization.

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Section: Discussionmentioning

confidence: 99%

“…As the design of biomaterials in combination with AMPs has shown excellent potential for in vivo applications, this review focused on evaluating biomaterial‐based AMP therapies. [ 138 ]…”

Section: Discussionmentioning

confidence: 99%

Advances of Antimicrobial Peptide‐Based Biomaterials for the Treatment of Bacterial Infections

Lai

Shan

2023

Advanced Science

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“…The high affinity of GN-based materials towards membrane proteoglycans leads to membrane damage. Another mechanism of action is the further internal leakage of GN-based materials into cells which can lead to the inhibition of DNA/RNA replication [ 8 ]. Therefore, it is proposed that the mode of action of GN towards bacteria is by physical means as well as by chemical means [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Graphene@Curcumin-Copper Paintable Coatings for the Prevention of Nosocomial Microbial Infection

Oves

Ansari

et al. 2023

Molecules

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The rise of antimicrobial resistance has brought into focus the urgent need for the next generation of antimicrobial coating. Specifically, the coating of suitable antimicrobial nanomaterials on contact surfaces seems to be an effective method for the disinfection/contact killing of microorganisms. In this study, the antimicrobial coatings of graphene@curcumin-copper (GN@CR-Cu) were prepared using a chemical synthesis methodology. Thus, the prepared GN@CR-Cu slurry was successfully coated on different contact surfaces, and subsequently, the GO in the composite was reduced to graphene (GN) by low-temperature heating/sunlight exposure. Scanning electron microscopy was used to characterize the coated GN@CR-Cu for the coating properties, X-ray photon scattering were used for structural characterization and material confirmation. From the morphological analysis, it was seen that CR and Cu were uniformly distributed throughout the GN network. The nanocomposite coating showed antimicrobial properties by contact-killing mechanisms, which was confirmed by zone inhibition and scanning electron microscopy. The materials showed maximum antibacterial activity against E. coli (24 ± 0.50 mm) followed by P. aeruginosa (18 ± 0.25 mm) at 25 µg/mL spot inoculation on the solid media plate, and a similar trend was observed in the minimum inhibition concentration (80 µg/mL) and bactericidal concentration (160 µg/mL) in liquid media. The synthesized materials showed excellent activity against E. coli and P. aeruginosa. These materials, when coated on different contact surfaces such medical devices, might significantly reduce the risk of nosocomial infection.

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“…These are materials with one or more dimensions in the nanoscale range of 1–100 nm due to which they exhibit unique physiochemical properties compared to bulk materials. Nanoparticles have a high surface-to-volume ratio, which contributes to their chemical reactivity and biological activities, and their small size allows them to easily penetrate microbial cell membranes and the biofilm EPS layer, resulting in irreversible cell damage and, eventually, cell death. − Therefore, nanocoating materials are used to modify the surface properties of intrinsic medical devices/implants in order to prevent biofilm infections. To target the first step of biofilm formation, namely, the attachment of planktonic bacteria to implant surfaces, one approach is to make the surface resistant to biofilm formation and to obstruct the protein adsorption process.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterial-Based Antimicrobial Coating for Biomedical Implants: New Age Solution for Biofilm-Associated Infections

et al. 2022

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Recently, the upsurge in hospital-acquired diseases has put global health at risk. Biomedical implants being the primary source of contamination, the development of biomedical implants with antimicrobial coatings has attracted the attention of a large group of researchers from around the globe. Bacteria develops biofilms on the surface of implants, making it challenging to eradicate them with the standard approach of administering antibiotics. A further issue of current concern is the fast resurgence of resistance to conventional antibiotics. As nanotechnology continues to advance, various types of nanomaterials have been created, including 2D nanoparticles and metal and metal oxide nanoparticles with antimicrobial properties. Researchers from all over the world are using these materials as a coating agent for biomedical implants to create an antimicrobial environment. This comprehensive and contemporary review summarizes various metals, metal oxide nanoparticles, 2D nanomaterials, and their composites that have been used or may be used in the future as an antimicrobial coating agent for biomedical implants, as well as their succinct mode of action to combat biofilm-associated infection and diseases.

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Antimicrobial mechanisms of biomaterials: from macro to nano

Abstract: Overcoming the global concern of antibiotic resistance is one of the biggest challenge faced by scientists today and the key to tackle this issue of emerging infectious diseases is the...

Cited by 36 publications

References 260 publications

Advances of Antimicrobial Peptide‐Based Biomaterials for the Treatment of Bacterial Infections

Advances of Antimicrobial Peptide‐Based Biomaterials for the Treatment of Bacterial Infections

Graphene@Curcumin-Copper Paintable Coatings for the Prevention of Nosocomial Microbial Infection

Nanomaterial-Based Antimicrobial Coating for Biomedical Implants: New Age Solution for Biofilm-Associated Infections

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