Antimicrobial Metabolites from the Endophytic Fungus Pichia guilliermondii Isolated from Paris polyphylla var. yunnanensis

Zhao, Jianglin; Mou, Yan; Shan, Tijiang; Li, Yan; Zhou, Ligang; Wang, Mingan; Wang, Jingguo

doi:10.3390/molecules15117961

Cited by 150 publications

(74 citation statements)

References 30 publications

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“…The biodegradation of a mixture of pentachlorophenol (PCP), 2-chlorophenol (2-CP), 2,4-dichlorophenol (2,4-DCP), and 2,4,6-trichlorophenol (2,4,6-TCP) using fungal laccases produced by Trametes pubescens was evaluated by Gaitan et al (2011). Laccases are also able to metabolize dichlorodiphenyltrichloroethane (DDT) in soil (Zhao et al 2010) and biodegrade 2,4-dichlorophenol (Bhattacharya et al 2009). …”

Section: Bioremediation Of the Environment And Detoxification Of Efflmentioning

confidence: 99%

Fungal laccase discovered but yet undiscovered

Agrawal

Chaturvedi

Verma

2018

Bioresour. Bioprocess.

191

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Laccases belongs to multinuclear copper-containing oxidase and can act on a variety of aromatic and non-aromatic compounds. Due to their broad substrate specificity, they are considered as a promising candidate in various industrial and biotechnological sectors. They are regarded as a "Green Tool"/"Green Catalyst" in biotechnology. The present review focuses on structure, reaction mechanism, categories, applications, economic feasibility, limitations, and future prospects of fungal laccases. Thus, this review would help in understanding laccases along with the areas, which has not been focused and requires attention. Since past, immense work has been carried out on laccases: yet, new discoveries and application are ever increasing which includes bio-fuel, bio-sensor, fiber board synthesis, bioremediation, clinical, textile industry, food, cosmetics, and many more. Hence, it can be stated that fungal laccase is an enzyme which is "discovered but yet undiscovered".

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Section: Bioremediation Of the Environment And Detoxification Of Efflmentioning

confidence: 99%

Fungal laccase discovered but yet undiscovered

Agrawal

Chaturvedi

Verma

2018

Bioresour. Bioprocess.

191

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“…Even though the evidence is still not incontrovertible, the possibility that the bioactive metabolites found in medical plants may derive from the activity of endophytic microorganisms cannot be excluded; endophytes may promote plant health and growth, elicit plant metabolism, or directly produce biotechnologically relevant compounds (Brader et al, 2014). Moreover, Zhao et al (2010) found that the metabolites derived from the endophytes found in Pichia guilliermondii were potential antimicrobial agents, which confirms our understanding of the relationship between the endophytes and their host. In this context, the characterization of uncultivatable microorganism communities is a fundamental step towards the production of natural antimicrobial agents because it paves the way to understanding the important role played by endophytes in plant metabolism.…”

Section: Resultsmentioning

confidence: 57%

Microbial diversity in Paris polyphylla var. yunnanensis rhizomes of varying ages

Yang¹,

Sc²,

Zhao³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Endophyte microorganisms live inside plants without causing them any apparent damage. Recently, endophytic microorganisms have attracted attention because they can produce bioactive compounds of biotechnological interest. The endophytic microorganisms in Paris polyphylla var. yunnanensis (Liliaceae) -a species used since antiquity in traditional Chinese medicine -are under scrutiny because they may be responsible for producing the bioactive metabolites associated with the plant. The levels of bioactive metabolites in the rhizomes of P. polyphylla increase with rhizome age. To elucidate the roles played by endophytes in the accumulation of bioactive metabolites, we investigated the community structure and diversity of the endophytic microorganisms in P. polyphylla rhizomes of different ages (4, 6, and 8 years) using 16S rRNA and internal transcribed spacer (ITS) sequence analysis. 16S rDNA amplicon pyrosequencing revealed that the number of operational taxonomic units was lower in the 8-year-old samples than in the other samples. A total of 28 phyla were observed in the P. polyphylla samples and the predominant (2015) bacteria were of the Cyanobacteria and Proteobacteria phyla. Moreover, the percentage of Cyanobacteria increased with rhizome age. Similarly, ITS1 amplicon pyrosequencing identified developmental changes in the most abundant fungal classes; some classes were more prevalent in the 8-year-old rhizomes than in younger rhizomes, indicating the importance in secondary metabolism in older rhizomes. Our study showed that endophyte microorganism diversity and prevalence depend on P. polyphylla rhizome age. There was also an indication that some endophyte microorganisms contribute to the higher saponin content in older P. polyphylla specimens.

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“…Some studies have also reported the isolation of M. caribbica from other sources, such as the digestive tract of Aedes aegypti (Gusmão et al, 2007) and fermented beverages (Papalexandratou and Vuyst, 2011;Hidalgo et al, 2012). M. guilliermondii has also been isolated as an endophytic yeast (Zhao et al, 2010) from bovine milk (Zaragoza et al, 2011) and the genital tract of female camels (Shokri et al, 2010). These species have been cited in literature as producers of xylitol (Rao et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Isolation and characterization of yeasts capable of efficient utilization of hemicellulosic hydrolyzate as the carbon source

et al. 2015

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ABSTRACT.Few yeasts have shown the potential to efficiently utilize hemicellulosic hydrolyzate as the carbon source. In this study, microorganisms isolated from the Manaus region in Amazonas, Brazil, were characterized based on their utilization of the pentoses, xylose, and arabinose. The yeasts that showed a potential to assimilate these sugars were selected for the better utilization of lignocellulosic biomass. Two hundred and thirty seven colonies of unicellular microorganisms grown on hemicellulosic hydrolyzate, xylose, arabinose, and yeast nitrogen base selective medium were analyzed. Of these, 231 colonies were subjected to sugar assimilation tests. One hundred and twenty five of these were shown to utilize hydrolyzed hemicellulose, xylose, or arabinose as the carbon source for growth. The colonies that showed the best growth (N = 57) were selected, and their internal transcribed spacer-5.8S rDNA was sequenced. The sequenced strains formed four distinct groups in the phylogenetic tree, and showed a high percentage 11605-11612 (2015) of similarity with Meyerozyma caribbica, Meyerozyma guilliermondii, Trichosporon mycotoxinivorans, Trichosporon loubieri, Pichia kudriavzevii, Candida lignohabitans, and Candida ethanolica. The discovery of these xylose-fermenting yeasts could attract widespread interest, as these can be used in the cost-effective production of liquid fuel from lignocellulosic materials.

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Antimicrobial Metabolites from the Endophytic Fungus Pichia guilliermondii Isolated from Paris polyphylla var. yunnanensis

Cited by 150 publications

References 30 publications

Fungal laccase discovered but yet undiscovered

Fungal laccase discovered but yet undiscovered

Microbial diversity in Paris polyphylla var. yunnanensis rhizomes of varying ages

Isolation and characterization of yeasts capable of efficient utilization of hemicellulosic hydrolyzate as the carbon source

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