Antimicrobial, modulatory, and antibiofilm activity of tt-farnesol on bacterial and fungal strains of importance to human health

Lopes, Alyne Pereira; Branco, Renata Rodrigues de Oliveira Castelo; Oliveira, Felipe Araújo de Alcântara; Campos, Marina Alicea Santana; Sousa, Bianca de Carvalho; Agostinho, Ítala Rossana Costa; Gonzalez, Alice Gonçalves Martins; Rocha, Jefferson Almeida; Pinheiro, Raizza Eveline Escórcio; Araújo, Alyne Rodrigues de; Soares, Maria José dos Santos

doi:10.1016/j.bmcl.2021.128192

Cited by 14 publications

(5 citation statements)

References 43 publications

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“…For example, we detected that 33, 36, and 3 Lachnopiraceae strains produced farnesol, trans‐farnesol, and 2,3‐dihydrofarnesol, respectively. Farnesol and its isomers or derivatives have been reported to be able to regulate host metabolisms and had anti‐inflammatory functions [ 67 , 68 ]. Antimicrobial and antifungal alcohols were also produced by many of Lachnopiraceae strains, such as geraniol ( n = 26) [ 69 ], nonyl alcohol ( n = 17) [ 70 ], 2‐undecanol ( n = 6) [ 71 ], decyl alcohol ( n = 23), and 1‐octanol ( n = 3) (Supporting Information Table S4B ).…”

Section: Resultsmentioning

confidence: 99%

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Metabolite profiling of human‐originated Lachnospiraceae at the strain level

Abdugheni

Wang

et al. 2022

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The human gastrointestinal (GI) tract harbors diverse microbes, and the family Lachnospiraceae is one of the most abundant and widely occurring bacterial groups in the human GI tract. Beneficial and adverse effects of the Lachnospiraceae on host health were reported, but the diversities at species/strain levels as well as their metabolites of Lachnospiraceae have been, so far, not well documented. In the present study, we report on the collection of 77 human‐originated Lachnospiraceae species (please refer hLchsp, https://hgmb.nmdc.cn/subject/lachnospiraceae) and the in vitro metabolite profiles of 110 Lachnospiraceae strains (https://hgmb.nmdc.cn/subject/lachnospiraceae/metabolites). The Lachnospiraceae strains in hLchsp produced 242 metabolites of 17 categories. The larger categories were alcohols (89), ketones (35), pyrazines (29), short (C2–C5), and long (C > 5) chain acids (31), phenols (14), aldehydes (14), and other 30 compounds. Among them, 22 metabolites were aromatic compounds. The well‐known beneficial gut microbial metabolite, butyric acid, was generally produced by many Lachnospiraceae strains, and Agathobacter rectalis strain Lach‐101 and Coprococcus comes strain NSJ‐173 were the top 2 butyric acid producers, as 331.5 and 310.9 mg/L of butyric acids were produced in vitro, respectively. Further analysis of the publicly available cohort‐based volatile‐metabolomic data sets of human feces revealed that over 30% of the prevailing volatile metabolites were covered by Lachnospiraceae metabolites identified in this study. This study provides Lachnospiraceae strain resources together with their metabolic profiles for future studies on host–microbe interactions and developments of novel probiotics or biotherapies.

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Section: Resultsmentioning

confidence: 99%

“…Average peak intensities were mean‐centered and unit‐scaled. All the processes of data analysis and visualization were conducted by using the ggplot2 package [ 23 ], RColorBrewer [ 68 ], and complex‐heatmap package in R [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Metabolite profiling of human‐originated Lachnospiraceae at the strain level

Abdugheni

Wang

et al. 2022

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“…Therefore, terpene acrylates 2a-d (Scheme 1) DOI: 10.15826/chimtech.2024.11.2.09 based on geraniol, S-perillyl alcohol, R-myrtenol and farnesol were selected as the initial terpene-containing compounds. Previously, farnesol activity was shown against such cell strains as S. aureus ATCC 43300 (MIC 0.128 mg/mL), S. epidermidis ATCC 12228 (0.032 mg/mL); however, farnesol does not show activity against most strains and clinical isolates [39]. Some geraniol derivatives have also been shown to have activity against Candida albicans (MIC 0.025 mg/mL) [40].…”

Section: Synthesis Of the Meroterpenoidsmentioning

confidence: 99%

Cationic amphiphilic meroterpenoids: synthesis, antibacterial, antifungal and mutagenic activity

Akhmedov,

Gamirov,

Panina

et al. 2024

Chim.Tech.Acta

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In this research, using the thia-Michael reaction, cationic amphiphilic meroterpenoids containing fragments of mono- and sesquiterpenoids were synthesized. The bacteriostatic and fungistatic activity of synthesized meroterpenoids against the fungi Saccharomyces cerevisiae and Candida sp., Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis) and Gram-negative (Salmonella typhimurium, Klebsiella pneumoniae, Pseudomonas aeruginosa) bacteria was studied. The compound containing the farnesyl fragment was most active against Saccharomyces cerevisiae (MIC 0.039 mg/mL), Candida sp. (MIC 0.078 mg/mL), Gram-positive bacteria Staphylococcus epidermidis (MIC 0.02 mg/mL) and Gram-negative Salmonella typhimurium (MIC 0.078 mg/mL). Besides, the Ames test demonstrated the absence of direct mutagenic action in all the studied compounds.

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“…In addition to citronellal and citronellol, the GcEO is composed of multiple molecules in minor concentrations (including farnesol, citronellyl acetate, β-caryophyllene, caryophyllene oxide and α-pinene). In general, the antimicrobial effect of EOs containing these molecules is well documented (Allenspach and Steuer, 2021;Liu et al, 2018;Lopes et al, 2021;, and it is reasonable to hypothesize that this myriad of active molecules results in a synergistic action among its components, which enhances the protective effect of the EO. Therefore, the EO can act in different plant defense mechanisms against several stress situations (Langat et al, 2021;Zengin and Baysal, 2014).…”

Section: Mode Of Action Of the Gceo On A Alternaria Conidiamentioning

confidence: 99%