Antimicrobial Natural Products

Song, Fuhang

doi:10.3390/antibiotics11121765

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…These compounds have been shown to have a wide range of pharmacological activities, including anti-inflammatory, antioxidant, and antimicrobial properties [9,10]. They are often used in traditional medicine and are being studied for their potential to treat a variety of health problems, such as infections, inflammation, cancer, and cardiovascular disease [11]. However, the use of secondary metabolites alone cannot replace antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Antimicrobial Activity through Synergistic Effects of Cold Atmospheric Plasma and Plant Secondary Metabolites: Opportunities and Challenges

Prasad,

Sasi,

Weerasinghe

et al. 2023

Molecules

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The emergence of antibiotic resistant microorganisms possesses a great threat to human health and the environment. Considering the exponential increase in the spread of antibiotic resistant microorganisms, it would be prudent to consider the use of alternative antimicrobial agents or therapies. Only a sustainable, sustained, determined, and coordinated international effort will provide the solutions needed for the future. Plant secondary metabolites show bactericidal and bacteriostatic activity similar to that of conventional antibiotics. However, to effectively eliminate infection, secondary metabolites may need to be activated by heat treatment or combined with other therapies. Cold atmospheric plasma therapy is yet another novel approach that has proven antimicrobial effects. In this review, we explore the physiochemical mechanisms that may give rise to the improved antimicrobial activity of secondary metabolites when combined with cold atmospheric plasma therapy.

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Section: Introductionmentioning

confidence: 99%

Enhanced Antimicrobial Activity through Synergistic Effects of Cold Atmospheric Plasma and Plant Secondary Metabolites: Opportunities and Challenges

Prasad,

Sasi,

Weerasinghe

et al. 2023

Molecules

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Anti-microbial efficacy and notable biocompatibility of Rosa damascene and Citrus sinensis biomass-derived metabolites

Francis

Namasivayam

Kavisri

et al. 2023

Biomass Conv. Bioref.

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Antibacterial Activity and AbFtsZ Binding Properties of Fungal Metabolites Isolated from Mexican Mangroves

Carrillo-Jaimes,

Fajardo-Hernández,

Hernández-Sedano

et al. 2024

Rev. Bras. Farmacogn.

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Antimicrobial resistance is emerging as a global health challenge that requires immediate and concerted attention. Accordingly, the WHO has issued alerts urging to continue developing antibiotics with novel mechanisms of action toward clinically important pathogens, including Acinetobacter baumannii. In this context, fungi have played a crucial role in the discovery and development of antibiotics. Therefore, in this work, three fungal strains were prioritized based on their metabolic profiles and antibacterial activity against a pan-resistant isolate of A. baumannii, to identify potential antibiotic molecules. Chemical investigation of the selected fungi (mangrove endophytes) led to the isolation of asperazine (1), aurasperone B (2), aurasperone F (3), TMC-256A1 (4), fonsecin B (5), dianhydroaurasperone C (6), aurasperone A (7), pyrophen (8), and penicillide (9). Moreover, an in vitro assay to detect ligands of the filamentous temperature-sensitive mutant Z enzyme of A. baumannii (AbFtsZ), a GTPase that plays a central role in bacterial division, was developed to correlate the antibacterial properties of the isolated molecules to a mechanism of action. Compounds 1–4 and 9 inhibited the growth of A. baumannii. Interestingly, compounds 2, 3, and 5–9 interacted with AbFtsZ1-412, increasing its GTPase activity. Conversely, compound 4 exhibited an outstanding ability to act as an inhibitor of both the enzymatic activity and the growth of the strain under study. Graphical Abstract

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Antimicrobial Natural Products

Abstract: Infectious diseases, resulting from microbial pathogens, are one of the major causes of morbidity and mortality worldwide [...]

Cited by 5 publications

References 12 publications

Enhanced Antimicrobial Activity through Synergistic Effects of Cold Atmospheric Plasma and Plant Secondary Metabolites: Opportunities and Challenges

Enhanced Antimicrobial Activity through Synergistic Effects of Cold Atmospheric Plasma and Plant Secondary Metabolites: Opportunities and Challenges

Anti-microbial efficacy and notable biocompatibility of Rosa damascene and Citrus sinensis biomass-derived metabolites

Antibacterial Activity and AbFtsZ Binding Properties of Fungal Metabolites Isolated from Mexican Mangroves

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