Antimicrobial nitric oxide releasing surfaces based on S-nitroso-N-acetylpenicillamine impregnated polymers combined with submicron-textured surface topography

Wo, Yaqi; Xu, Li Chong; Zi, Li; Matzger, Adam J.; Meyerhoff, Mark E.; Siedlecki, Christopher A.

doi:10.1039/c7bm00108h

Cited by 34 publications

(40 citation statements)

References 52 publications

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“…NO releasing materials may be ideal candidates for the development of novel biomedical devices which can effectively prevent bacterial infection and thrombus formation, since NO is identified to be capable of preventing platelet activation and adhesion, and inhibiting bacterial proliferation and biofilm formation [109]. S -Nitroso- N -acetylpenicillamine (SNAP), a commonly used nitrosothiol typed NO donor, has been extensively investigated to incorporate into biomedical grade polymers to create NO releasing materials [159,160,161,162,163] because of its low cost, safety, stability during release and storage, demonstrating the potential for long-term applications [164]. Meyerhoff and Handa et al prepared NO releasing catheters by doping SNAP into the Elast-Eon E2As polymers [67].…”

Section: No Releasing Polymers Applied In Indwelling Medical Devicesmentioning

confidence: 99%

Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review

et al. 2019

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Polymeric materials releasing nitric oxide have attracted significant attention for therapeutic use in recent years. As one of the gaseous signaling agents in eukaryotic cells, endogenously generated nitric oxide (NO) is also capable of regulating the behavior of bacteria as well as biofilm formation in many metabolic pathways. To overcome the drawbacks caused by the radical nature of NO, synthetic or natural polymers bearing NO releasing moiety have been prepared as nano-sized materials, coatings, and hydrogels. To successfully design these materials, the amount of NO released within a certain duration, the targeted pathogens and the trigger mechanisms upon external stimulation with light, temperature, and chemicals should be taken into consideration. Meanwhile, NO donors like S-nitrosothiols (RSNOs) and N-diazeniumdiolates (NONOates) have been widely utilized for developing antimicrobial polymeric agents through polymer-NO donor conjugation or physical encapsulation. In addition, antimicrobial materials with visible light responsive NO donor are also reported as strong and physiological friendly tools for rapid bacterial clearance. This review highlights approaches to delivery NO from different types of polymeric materials for combating diseases caused by pathogenic bacteria, which hopefully can inspire researchers facing common challenges in the coming ‘post-antibiotic’ era.

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Section: No Releasing Polymers Applied In Indwelling Medical Devicesmentioning

confidence: 99%

Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review

et al. 2019

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“…As a prominent gasotransmitter, NO has been demonstrated to influence abundant physiological processes including cell apoptosis, angiogenesis, immune responses, neurotransmission, etc . Therefore, NO has been extensively explored in versatile biomedical applications such as cardiovascular homeostasis, bone metabolism and neurotransmission, respiratory diseases, antimicrobial therapy, wound healing, and antibacterial . Especially, NO can efficiently kill the cancer cells via the nitrosation of mitochondria and DNA, paving the new way for NO‐induced cancer therapy .…”

Section: Nitric Oxide (No)‐generating Ggnsmentioning

confidence: 99%

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

2018

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The fast advances of theranostic nanomedicine enable the rational design and construction of diverse functional nanoplatforms for versatile biomedical applications, among which gas-generating nanoplatforms (GGNs) have emerged very recently as unique theranostic nanoplatforms for broad gas therapies. Here, the recent developments of the rational design and chemical construction of versatile GGNs for efficient gas therapies by either exogenous physical triggers or endogenous disease-environment responsiveness are reviewed. These gases involve some therapeutic gases that can directly change disease status, such as oxygen (O ), nitric oxide (NO), carbon monoxide (CO), hydrogen (H ), hydrogen sulfide (H S) and sulfur dioxide (SO ), and other gases such as carbon dioxide (CO ), dl-menthol (DLM), and gaseous perfluorocarbon (PFC) for supplementary assistance of the theranostic process. Abundant nanocarriers have been adopted for gas delivery into lesions, including poly(d,l-lactic-co-glycolic acid), micelles, silica/mesoporous silica, organosilica, MnO , graphene, Bi Se , upconversion nanoparticles, CaCO , etc. Especially, these GGNs have been successfully developed for versatile biomedical applications, including diagnostic imaging and therapeutic use. The biosafety issue, challenges faced, and future developments on the rational construction of GGNs are also discussed for further promotion of their clinical translation to benefit patients.

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“…The textured PU film surfaces with ordered arrays of pillars were prepared by a modified soft lithography two-stage replication molding technique and impregnated with SNAP as described previously. [30] Briefly, a PDMS mold was obtained by casting against the Si wafer with the pattern of 700/700/300 nm and cured at 65°C under vacuum for 6 hrs to provide a negative silicone mold. A CarboSil PU solution was then spin-coated onto the silicon mold to prepare the textured PU films.…”

Section: Preparation Of Biomimetic Pu Films With Surface Texturing and No Releasementioning

confidence: 99%

“…Toward this goal, we recently created a dual functional surface with a combination of surface texturing and NO release integrated on PU biomaterials, where S-nitroso-Nacetylpenicillamine (SNAP) was used as the NO donor within the PU and the surface was textured with submicron pillar patterns (Scheme 1). [29,30] Results showed that the combination of surface texturing and NO release synergistic or additively reduced bacterial adhesion and inhibited biofilm formation. Moreover, utilizing an impregnation of SNAP in the polymer led to NO release at a stable and long term NO release for up to 38 days for 15% SNAP load, far longer than the NO release lifetime using a SNAP-doped PU with same amount of SNAP load.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, utilizing an impregnation of SNAP in the polymer led to NO release at a stable and long term NO release for up to 38 days for 15% SNAP load, far longer than the NO release lifetime using a SNAP-doped PU with same amount of SNAP load. [30] While bacterial adhesion and biofilm formation on these biomimetic surfaces prepared with both texturing and NO release have been studied, the blood coagulation responses to such dual functioning surfaces have not yet been characterized. Herein we studied plasma coagulation, platelet adhesion/activation and plasma protein adsorption on such surfaces to understand the blood compatibility of these biomaterials.…”

Section: Introductionmentioning

confidence: 99%

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Blood coagulation response and bacterial adhesion to biomimetic polyurethane biomaterials prepared with surface texturing and nitric oxide release

Meyerhoff

Siedlecki

2019

Acta Biomaterialia

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A dual functional polyurethane (PU) film that mimics aspects of blood vessel inner surfaces by combining surface texturing and nitric oxide (NO) release was fabricated through a soft lithography two-stage replication process. The fabrication of submicron textures on the polymer surface was followed by solvent impregnation with the NO donor, S-nitroso-N-acetylpenicillamine (SNAP). An in vitro plasma coagulation assay showed that the biomimetic surface significantly increased the plasma coagulation time and also exhibited reduced platelet adhesion and activation, thereby reducing the risk of blood coagulation and thrombosis. A contact activation assay for coagulation factor XII (FXII) demonstrated that both NO release and surface texturing also reduced FXII contact activation, which contributes to the inhibition of plasma coagulation. The biomimetic surface was also evaluated for bacterial adhesion in plasma and results demonstrate that this combined strategy enables a synergistic effect to reduce bacterial adhesion of Staphylococcus epidermidis, Staphylococcus aureus, and Pseudomonas aeruginosa microorganisms. The results strongly suggest that the biomimetic modification with surface texturing and NO release provides an effective approach to improve the biocompatibility of polymeric materials in combating thrombosis and microbial infection.

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Antimicrobial nitric oxide releasing surfaces based on S-nitroso-N-acetylpenicillamine impregnated polymers combined with submicron-textured surface topography

Cited by 34 publications

References 52 publications

Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review

Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

Blood coagulation response and bacterial adhesion to biomimetic polyurethane biomaterials prepared with surface texturing and nitric oxide release

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