Antimicrobial peptides (AMP) with antiviral activity against fish nodavirus

Two hepcidins from spotted scat (Scatophagus argus) possess antibacterial and antiviral functions in vitro

“…Antiviral activity against both enveloped and non-enveloped viruses has been reported for several fish hepcidins [1,7,9,16,17,27]. Therefore, enveloped virus SCRV and nonenveloped virus MsReV were selected for studies of the antiviral activity of synthesized SA-hepcidins.…”

“…Fish secrete several types of antimicrobial peptides (AMPs), which are positively charged short molecules with antibacterial, antiviral, antifungal, antiparasitic, and immunomodulatory functions [1]. Hepcidin, a cysteine-rich AMP, has identified in many vertebrates.…”

“…In addition to antibacterial activity, some fish hepcidins have been reported to possess antiviral activity. The most well-studied fish hepcidin is synthetic hepcidin TH1-5 from tilapia, which has antiviral activity against infectious pancreatic necrosis virus [27], Japanese encephalitis virus [9], and nervous necrosis virus [1,7]. Recombinant Pro-Omhep1 and synthetic Omhep1 from medaka have been shown to inhibit replication of the white spot syndrome virus [16].…”

Importance of Fish Antimicrobial Peptides for Aquaculture and Biomedicine

“…A large number of AMPs have been isolated from a wide number of fish species during last years, among which pleurocidin from winter flounder (Pleuronectes americanus) [2], cathelicidins from rainbow trout (Oncorhynchus mykiss) [3], defensins from zebrafish (Danio rerio) [4], piscidins from hybrid striped bass (white bass, Morone chrysops, female, x striped bass, Morone saxatilis, male) [5], dicentracin from sea bass (Dicentrarchus labrax) [6], and hepcidin from channel catfish (Ictalurus punctatus) [7], epinecidin from the grouper (Epinephelus coiodes) [8] (for a review see [9]). The activity of fish AMPs have been tested not only against the more common fish bacterial pathogens [8,10] but either against other pathogens like nervous necrosis virus [11]. Moreover, some AMPs have shown dual functional aspects, like hepcidins that have been indicated to be involved in iron regulation [12].…”

Barramundi Aquaculture

“…The causative agent is an RNA virus with a diameter of 20 -34 nm (Wu & Chi 2006 ;Chia et al . 2010 ).…”