Antimicrobial Peptides as a Promising Therapeutic Strategy for Neisseria Infections

Askari, Parvin; Yousefi, Masoud; Foadoddini, Mohsen; Neshani, Alireza; Aganj, Mahdi; Lotfi, Nasim; Movaqar, Aref; Ghazvini, Kiarash; Namaei, Mohammad Hasan

doi:10.1007/s00284-022-02767-y

Cited by 4 publications

(1 citation statement)

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“…Not only were the levels significantly higher than anticipated, but the distribution of nisin sensitivity was phylogenetically broad. For example, nisin sensitivity was detected across the breadth of Proteobacteria, including Escherichia , Neisseria [ 33 ] and Helicobacter . Coupled with the nisin sensitivity data reported for Gram-positive bacteria [ 34 ], it is reasonable to assume that nisin sensitivity is an ancestral state and insensitivity has evolved multiple times in separate lineages.…”

Section: Discussionmentioning

confidence: 99%

Nisin Inhibition of Gram-Negative Bacteria

Charest,

Reed,

Bozorgzadeh

et al. 2024

Microorganisms

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Aims: This study investigates the activity of the broad-spectrum bacteriocin nisin against a large panel of Gram-negative bacterial isolates, including relevant plant, animal, and human pathogens. The aim is to generate supportive evidence towards the use/inclusion of bacteriocin-based therapeutics and open avenues for their continued development. Methods and Results: Nisin inhibitory activity was screened against a panel of 575 strains of Gram-negative bacteria, encompassing 17 genera. Nisin inhibition was observed in 309 out of 575 strains, challenging the prevailing belief that nisin lacks effectiveness against Gram-negative bacteria. The genera Acinetobacter, Helicobacter, Erwinia, and Xanthomonas exhibited particularly high nisin sensitivity. Conclusions: The findings of this study highlight the promising potential of nisin as a therapeutic agent for several key Gram-negative plant, animal, and human pathogens. These results challenge the prevailing notion that nisin is less effective or ineffective against Gram-negative pathogens when compared to Gram-positive pathogens and support future pursuits of nisin as a complementary therapy to existing antibiotics. Significance and Impact of Study: This research supports further exploration of nisin as a promising therapeutic agent for numerous human, animal, and plant health applications, offering a complementary tool for infection control in the face of multidrug-resistant bacteria.

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Section: Discussionmentioning

confidence: 99%