Antimicrobial peptides: bridging innate and adaptive immunity in the pathogenesis of psoriasis

Ma, Jingyi; Shao, Shuai; Wang, Gang

doi:10.1097/cm9.0000000000001240

Cited by 26 publications

(22 citation statements)

References 137 publications

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“…Among these components, there are antimicrobial peptides (AMPs). As important components of the animal innate immune system, AMPs have a strong immunomodulatory and antimicrobial properties and are able to activate and modulate the adaptive immune responses ( Lai and Gallo, 2009 ; Donnarumma et al., 2016 ; Liang and Diana, 2020 ; Ma et al., 2020 ). Recent studies demonstrated that AMPs are involved in the regulation of mucin and TJs expression and microbiota composition ( Liévin-Le Moal and Servin, 2006 ; Muniz et al., 2012 ; Kiatsurayanon et al., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Peptides Human Beta-Defensin-2 and -3 Protect the Gut During Candida albicans Infections Enhancing the Intestinal Barrier Integrity: In Vitro Study

Fusco

Savio

Donniacuo

et al. 2021

Front. Cell. Infect. Microbiol.

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The intestinal mucosa is composed of a monolayer of epithelial cells, which is highly polarized and firmly united to each other thanks to the presence of proteins complexes, called Tight junctions (TJs). Alteration of the mucus layer and TJs causes an increase in intestinal permeability, which can lead to a microbial translocation and systemic disorders. Candida albicans, in addition to its role of commensal, is an opportunistic pathogen responsible for disseminated candidiasis, especially in immunocompromised subjects where the dysbiosis leads to damage of the intestinal mucosal barrier . In this work, we used a line of intestinal epithelial cells able to stably express the genes that encodes human beta defensin-2 (HBD-2) and -3 (HBD-3) to monitor the invasion of C. albicans in vitro. Defensins are a group of antimicrobial peptides (AMPs) found in different living organisms, and are involved in the first line of defense in the innate immune response against pathogens. The results obtained show that the presence of antimicrobial peptides improves the expression of TJs and increases the Trans Epithelial Electrical Resistence value. In addition, the invasive ability of C. albicans in transfected cells is significantly reduced, as well as the expression levels of genes involved in the apoptotic pathway. Through the study of interaction between antimicrobial peptides and microbiota we will be able in the future to better understand the mechanisms by which they exert the host defense function against intestinal pathogens.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Peptides Human Beta-Defensin-2 and -3 Protect the Gut During Candida albicans Infections Enhancing the Intestinal Barrier Integrity: In Vitro Study

Fusco

Savio

Donniacuo

et al. 2021

Front. Cell. Infect. Microbiol.

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“…The wide spectrum of defensin activity on immunocompetent cells, their selectivity and ability to shift the proinflammatory response to an antiinflammatory one have led to the assumption that the immunomodulatory activity of defensins is no less important than the antibacterial activity, and it serves as a key factor in the binding of the innate and adaptive immune response [ 136 , 189 , 190 ].…”

Section: Immunomodulatory Activity Of Ampsmentioning

confidence: 99%

Immunomodulatory and Allergenic Properties of Antimicrobial Peptides

Guryanova

Ovchinnikova

2022

IJMS

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With the growing problem of the emergence of antibiotic-resistant bacteria, the search for alternative ways to combat bacterial infections is extremely urgent. While analyzing the effect of antimicrobial peptides (AMPs) on immunocompetent cells, their effect on all parts of the immune system, and on humoral and cellular immunity, is revealed. AMPs have direct effects on neutrophils, monocytes, dendritic cells, T-lymphocytes, and mast cells, participating in innate immunity. They act on B-lymphocytes indirectly, enhancing the induction of antigen-specific immunity, which ultimately leads to the activation of adaptive immunity. The adjuvant activity of AMPs in relation to bacterial and viral antigens was the reason for their inclusion in vaccines and made it possible to formulate the concept of a “defensin vaccine” as an innovative basis for constructing vaccines. The immunomodulatory function of AMPs involves their influence on cells in the nearest microenvironment, recruitment and activation of other cells, supporting the response to pathogenic microorganisms and completing the inflammatory process, thus exhibiting a systemic effect. For the successful use of AMPs in medical practice, it is necessary to study their immunomodulatory activity in detail, taking into account their pleiotropy. The degree of maturity of the immune system and microenvironment can contribute to the prevention of complications and increase the effectiveness of therapy, since AMPs can suppress inflammation in some circumstances, but aggravate the response and damage of organism in others. It should also be taken into account that the real functions of one or another AMP depend on the types of total regulatory effects on the target cell, and not only on properties of an individual peptide. A wide spectrum of biological activity, including direct effects on pathogens, inactivation of bacterial toxins and influence on immunocompetent cells, has attracted the attention of researchers, however, the cytostatic activity of AMPs against normal cells, as well as their allergenic properties and low stability to host proteases, are serious limitations for the medical use of AMPs. In this connection, the tasks of searching for compounds that selectively affect the target and development of an appropriate method of application become critically important. The scope of this review is to summarize the current concepts and newest advances in research of the immunomodulatory activity of natural and synthetic AMPs, and to examine the prospects and limitations of their medical use.

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“…However, in most cases, the initial activation of innate immunity leads to the breaking of tolerance and persistence of autoimmunity, as evidenced by the activation of T helper (Th) 1 and Th17 arms of the adaptive immune system and the accumulation of oligoclonal T cells secreting INF-È and Th17-signature cytokines in the lesional skin [23,24]. Initial immune events in psoriasis are triggered in response to endogenous danger signals released by keratinocytes following stress, infection or injury, of which cathelicidin, human β-defensin and S100 proteins have been most studied [25,26]. In a simplified version, these antimicrobial peptides (AMPs), along with other released cytokines and chemokines, promote activation of dendritic cells, which in turn have an inherited capacity to present autoantigens to naïve autoantigen-specific T-helper cells in the regional draining lymph nodes, leading to their activation and clonal expansion.…”

Section: Immunopathogenesis Of Psoriasis Vulgarismentioning

confidence: 99%

Oxidative Stress Induced by High Salt Diet—Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction in Psoriasis vulgaris

et al. 2022

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Although oxidative stress is recognized as an important effector mechanism of the immune system, uncontrolled formation of reactive oxygen and nitrogen species promotes excessive tissue damage and leads to disease development. In view of this, increased dietary salt intake has been found to damage redox systems in the vessel wall, resulting in endothelial dysfunction associated with NO uncoupling, inflammation, vascular wall remodeling and, eventually, atherosclerosis. Several studies have reported increased systemic oxidative stress accompanied by reduced antioxidant capacity following a high salt diet. In addition, vigorous ionic effects on the immune mechanisms, such as (trans)differentiation of T lymphocytes are emerging, which together with the evidence of NaCl accumulation in certain tissues warrants a re-examination of the data derived from in vitro research, in which the ionic influence was excluded. Psoriasis vulgaris (PV), as a primarily Th17-driven inflammatory skin disease with proven inflammation-induced accumulation of sodium chloride in the skin, merits our interest in the role of oxidative stress in the pathogenesis of PV, as well as in the possible beneficial effects that could be achieved through modulation of dietary salt intake and antioxidant supplementation.

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Antimicrobial peptides: bridging innate and adaptive immunity in the pathogenesis of psoriasis

Cited by 26 publications

References 137 publications

Antimicrobial Peptides Human Beta-Defensin-2 and -3 Protect the Gut During Candida albicans Infections Enhancing the Intestinal Barrier Integrity: In Vitro Study

Antimicrobial Peptides Human Beta-Defensin-2 and -3 Protect the Gut During Candida albicans Infections Enhancing the Intestinal Barrier Integrity: In Vitro Study

Immunomodulatory and Allergenic Properties of Antimicrobial Peptides

Oxidative Stress Induced by High Salt Diet—Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction in Psoriasis vulgaris

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