Antimicrobial Peptides from Marine Invertebrates

Transcriptional regulation of selenium-dependent glutathione peroxidase from Venerupis philippinarum in response to pathogen and contaminants challenge

“…Similar tissue expression profiles were also found in H. discus discus, U. tumidus and C. farreri GPx transcripts [2,13,14], perhaps due to the fact that hepatopancreatic lysosomes were the sites for generation of ROS [31]. Moreover, VpSe-GPx mRNA was found moderately expressed in haemocytes which were known to be responsible for respiratory burst and killing foreign invaders in bivalve mollusks [32,33]. Mu et al reported that no significant difference of C. farreri GPx3 expression level was found in hepatopancreas post bacterial challenge.…”

A defensin from clam Venerupis philippinarum: Molecular characterization, localization, antibacterial activity, and mechanism of action

“…Humoral immunity in marine invertebrates is characterized by antimicrobial agents present in the hemolymph, among which AMPs play an important role in the host innate immune response (Tincu and Taylor, 2004). Many AMPs have been identified and characterized in marine mollusks up to now.…”

cDNA sequence and expression analysis of an antimicrobial peptide, theromacin, in the triangle-shell pearl mussel Hyriopsis cumingii

“…Marine invertebrates are solely dependent on physical barriers and the innate immune system for protection against pathogenic agents, and natural antibiotics have been shown to participate in the immune response during experimental bacterial challenges (Munoz et al, 2004). AMPs have been isolated from several marine invertebrates, including chelicerates, molluscs, and crustaceans (Tincu and Taylor, 2004). The first study on AMPs in bivalve molluscs was conducted in the 1990s using reverse genomics.…”