Antimicrobial photodynamic and wound healing activity of curcumin encapsulated in silica nanoparticles

Mirzahosseinipour, Mahtab; Khorsandi, Khatereh; Hosseinzadeh, Reza; Ghazaeian, Mehrgan; Shahidi, F.

doi:10.1016/j.pdpdt.2019.101639

Cited by 99 publications

(66 citation statements)

References 39 publications

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“…Previously, bacterial nanocellulose/iron oxide (BCN/Fe 3 O 4 ) nanofilms treatment showed improved HDF migration in in vitro scratch assay [ 83 ]. Mirzahosseinipour et al also found that curcumin-Silica NPs improve HDF cell migration and proliferation [ 85 ]. The silver-incorporated cotton fabrics were also exhibited significant in vivo wound healing effect [ 86 ].…”

Section: Resultsmentioning

confidence: 99%

Anti‐bacterial and wound healing‐promoting effects of zinc ferrite nanoparticles

et al. 2021

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Background Increasing antibiotic resistance continues to focus on research into the discovery of novel antimicrobial agents. Due to its antimicrobial and wound healing-promoting activity, metal nanoparticles have attracted attention for dermatological applications. This study is designed to investigate the scope and bactericidal potential of zinc ferrite nanoparticles (ZnFe2O4 NPs), and the mechanism of anti-bacterial action along with cytocompatibility, hemocompatibility, and wound healing properties. Results ZnFe2O4 NPs were synthesized via a modified co-precipitation method. Structure, size, morphology, and elemental compositions of ZnFe2O4 NPs were analyzed using X-ray diffraction pattern, Fourier transform infrared spectroscopy, and field emission scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy. In PrestoBlue and live/dead assays, ZnFe2O4 NPs exhibited dose-dependent cytotoxic effects on human dermal fibroblasts. In addition, the hemocompatibility assay revealed that the NPs do not significantly rupture red blood cells up to a dose of 1000 µg/mL. Bacterial live/dead imaging and zone of inhibition analysis demonstrated that ZnFe2O4 NPs showed dose-dependent bactericidal activities in various strains of Gram-negative and Gram-positive bacteria. Interestingly, NPs showed antimicrobial activity through multiple mechanisms, such as cell membrane damage, protein leakage, and reactive oxygen species generation, and were more effective against gram-positive bacteria. Furthermore, in vitro scratch assay revealed that ZnFe2O4 NPs improved cell migration and proliferation of cells, with noticeable shrinkage of the artificial wound model. Conclusions This study indicated that ZnFe2O4 NPs have the potential to be used as a future antimicrobial and wound healing drug.

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Section: Resultsmentioning

confidence: 99%

Anti‐bacterial and wound healing‐promoting effects of zinc ferrite nanoparticles

et al. 2021

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“…Remarkably, when CUR was encapsulated in silica nanoparticles, its efficacy against P. aeruginosa increased but the minimum inhibitory concentration was 1 mg/mL [21]. In our study, we evaluated the antimicrobial efficacy of curcumin delivered by three types of amphiphilic self‐assembling nanomicelles featuring a common C 16 ‐long hydrocarbon chain as the hydrophobic part and three different cationic moieties—namely DAPMA, SPD and SPM—bearing a nominal charge of +2, +2 and +3, respectively, at physiological pH (7.4).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of amphiphilic nanomicelles loaded with curcumin against Pseudomonas aeruginosa alone and activated by blue laser light

Rupel

Zupin

Brich

et al. 2020

Journal of Biophotonics

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The aim of this work was to assess the antimicrobial efficacy on Pseudomonas aeruginosa of nanomicelles loaded with curcumin (CUR) alone and activated by blue laser light in an antimicrobial photodynamic therapy (APDT) approach. First, free CUR in liquid suspension and loaded in three amphiphilic nanomicelles (CUR‐DAPMA, CUR‐SPD and CUR‐SPM) were tested both on bacteria and keratinocytes. While free CUR exerted limited efficacy showing moderate cytotoxicity, a strong inhibition of bacterial growth was obtained using all three nanosystems without toxicity on eukaryotic cells. CUR‐SPM emerged as the most effective, and was therefore employed in APDT experiments. Among the three sublethal blue laser (λ 445 nm) protocols tested, the ones characterized by a fluence of 18 and 30 J/cm2 further decreased the antimicrobial concentration to 50 nM. The combination of blue laser APDT with CUR‐SPM nanomicelles results in an effective synergistic activity that represents a promising novel therapeutic approach on resistant species.

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“…Additionally, it is reported that some PS tend to aggregate in water, which also limits an effective therapy (Huang et al, 2010). To overcome these issues, different types of nanocarriers and nanostructures, such as chitosan NPs, gold NPs, carbon nanotubes, and silica NPs, have been developed to deliver and protect PS (Darabpour et al, 2016(Darabpour et al, , 2017Anju et al, 2019a;Paramanantham et al, 2019; Parasuraman et al, 2019;Mirzahosseinipour et al, 2020). Rout et al studied the potential of Toluidine blue O in solution and in microemulsion, as well as Toluidine blue O in microemulsion with EDTA, in 16 h-old S. aureus and S. epidermidis biofilms.…”

Section: Photodynamic Therapy and Ultrasoundsmentioning

confidence: 99%

Innovative Strategies Toward the Disassembly of the EPS Matrix in Bacterial Biofilms

et al. 2020

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Bacterial biofilms represent a major concern at a worldwide level due to the high demand for implantable medical devices and the rising numbers of bacterial resistance. The complex structure of the extracellular polymeric substances (EPS) matrix plays a major role in this phenomenon, since it protects bacteria from antibiotics, avoiding drug penetration at bactericidal concentrations. Besides, this structure promotes bacterial cells to adopt a dormant lifestyle, becoming less susceptible to antibacterial agents. Currently, the available treatment for biofilm-related infections consists in the administration of conventional antibiotics at high doses for a long-term period. However, this treatment lacks efficiency against mature biofilms and for implant-associated biofilms it may be necessary to remove the medical device. Thus, biofilm-related infections represent an economical burden for the healthcare systems. New strategies focusing on the matrix are being highlighted as alternative therapies to eradicate biofilms. Here, we outline reported matrix disruptive agents, nanocarriers, and technologies, such as application of magnetic fields, photodynamic therapy, and ultrasounds, that have been under investigation to disrupt the EPS matrix of clinically relevant bacterial biofilms. In an ideal therapy, a synergistic effect between antibiotics and the explored innovated strategies is aimed to completely eradicate biofilms and avoid antimicrobial resistance phenomena.

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Antimicrobial photodynamic and wound healing activity of curcumin encapsulated in silica nanoparticles

Cited by 99 publications

References 39 publications

Anti‐bacterial and wound healing‐promoting effects of zinc ferrite nanoparticles

Anti‐bacterial and wound healing‐promoting effects of zinc ferrite nanoparticles

Antimicrobial activity of amphiphilic nanomicelles loaded with curcumin against Pseudomonas aeruginosa alone and activated by blue laser light

Innovative Strategies Toward the Disassembly of the EPS Matrix in Bacterial Biofilms

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