Antimicrobial photodynamic therapy against Propionibacterium acnes biofilms using hypericin (Hypericum perforatum) photosensitizer: in vitro study

Barroso, R. A.; Navarro, Ricardo Scarparo; Tim, Carla Roberta; Ramos, Lucas de Paula; Oliveira, Luciane Dias de; Araki, Ângela Toshie; Fernandes, Karina Gonzales Câmara; Macedo, Daniela Bezerra; Assis, Lívia

doi:10.1007/s10103-020-03163-3

Cited by 25 publications

(18 citation statements)

References 33 publications

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“…Cutibacterium acnes can also produce endogenous porphyrin to oxidize squalene and promote the formation of acne vulgaris in keratinocytes (16). There is evidence that Cutibacterium acnes lipase enzyme can hydrolyze sebum into glycerol and free fatty acids, which in turn stimulates hair follicles, leading to acne vulgaris (17). Cutibacterium acnes can stimulate immune cells to release IL-1β and because different individuals have different immune responses to pathogens, not all individuals develop acne vulgaris (18,19).…”

Section: Cutibacterium Acnes In Acne Vulgarismentioning

confidence: 99%

A narrative review of research progress on the role of NLRP3 inflammasome in acne vulgaris

Zhu¹,

Wang²,

Bu³

et al. 2022

Ann Transl Med

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Background and Objective: Acne vulgaris is a common skin disease around the world which affects the appearance of patients, as well as their physical and mental health. Cutibacterium acnes plays a vital role in the occurrence and development of acne vulgaris. Pattern recognition receptors (PRRs) are the first line of defense against external pathogens. The nucleotide oligomerization domain (NOD)-like receptor family pyrin containing 3 (NLRP3) inflammasome has recently been shown to contribute to the pathogenesis of acne vulgaris. The purpose of this review is to clarify the underlying mechanisms of NLRP3 inflammasome in the pathogenesis of acne vulgaris, and its potential as a therapeutic target for the condition.Methods: The PubMed database was searched for relevant articles published in English between January 2003 to December 2021 using keywords "acne vulgaris", "NLRP3 inflammasome", and "Cutibacterium acnes".The reference lists of retrieved articles were also reviewed to identify relevant articles.Key Content and Findings: Cutibacterium acnes infection can lead to a series of inflammatory reactions and the production of inflammatory factors such as interleukin (IL)-1β. In vitro and in vivo studies demonstrated that the NLRP3 inflammasome plays essential roles in acne vulgaris. Further, innate immunity and adaptive immunity pervade the entire pathogenesis of acne vulgaris. Conclusions:The NLRP3 inflammasome may be a potential therapeutic target for acne vulgaris. Future studies are needed to investigate the potential therapeutic effects of NLRP3 inhibitors on acne vulgaris.

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Section: Cutibacterium Acnes In Acne Vulgarismentioning

confidence: 99%

A narrative review of research progress on the role of NLRP3 inflammasome in acne vulgaris

Zhu¹,

Wang²,

Bu³

et al. 2022

Ann Transl Med

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“…Escherichia coli [268][269][270] Enterococcus faecalis [270] Propionibacterium acnes [271] Pseudomonas aeruginosa [270] Staphylococcus Saccharomyces cerevisiae [276] Fagopyrin F Tartary buckwheat (Fagopyrum tataricum)…”

Section: Bacillus Cereus [267]mentioning

confidence: 99%

Antimicrobial Effect of Phytochemicals from Edible Plants

Hochma

Yarmolinsky²,

Khalfin

et al. 2021

Processes

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Current strategies of combating bacterial infections are limited and involve the use of antibiotics and preservatives. Each of these agents has generally inadequate efficacy and a number of serious adverse effects. Thus, there is an urgent need for new antimicrobial drugs and food preservatives with higher efficacy and lower toxicity. Edible plants have been used in medicine since ancient times and are well known for their successful antimicrobial activity. Often photosensitizers are present in many edible plants; they could be a promising source for a new generation of drugs and food preservatives. The use of photodynamic therapy allows enhancement of antimicrobial properties in plant photosensitizers. The purpose of this review is to present the verified data on the antimicrobial activities of photodynamic phytochemicals in edible species of the world’s flora, including the various mechanisms of their actions.

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“…The most effective and non-toxic PS are porphyrins, chlorins and their derivatives (foscan, lutex, tookad, photofrin), which are currently used in the clinical practice of PDT [ 2 , 10 , 11 ]. Recently, along with porphyrin photosensitizers, a number of dyes of synthetic and natural origin (methylene blue, toluidine blue, rose bengal, curcumin, hypericin) capable of generating ROS upon excitation have been used in aPDT practice [ 12 , 13 , 14 , 15 , 16 ]. Such dyes are more accessible than porphyrins and practically do not concede to them in activity.…”

Section: Introductionmentioning

confidence: 99%

“…Such dyes are more accessible than porphyrins and practically do not concede to them in activity. It is important to note that many dyes have their own bactericidal activity, which can increase the effectiveness of PDT in the treatment of localized infections [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Chitosan and Amphiphilic Polymers on the Photosensitizing and Spectral Properties of Rose Bengal

et al. 2022

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The influence of chitosan (CS) and amphiphilic polymers (AP: pluronic F108 and polyvinylpyrrolidone (PVP)) on the photocatalytic activity of rose bengal (RB) in a model reaction of tryptophan photo-oxidation in phosphate-buffered saline (PBS) was studied. It was shown that in the presence of CS, the effective rate constant keff of tryptophan photo-oxidation catalyzed by RB in PBS solution decreases by a factor of two. This is due to the ionic interaction of the RB with the chitosan. Rose bengal in a slightly acidic environment (pH 4.5) passes into a neutral lactone form, which sharply reduces the photosensitizing properties of the dye. It was demonstrated that the introduction of AP into a solution containing RB and CS prevents direct interaction between RB and CS. This is evidenced by the presence of photocatalytic activity of the dye in the RB-AP-CS systems, as well as bathochromic shifts of the main absorption bands of the dye, and an increase in the optical density and luminescence intensity of the RB when AP is introduced into a buffer solution containing RB and chitosan. The presence of RB-CS and RB-AP interaction in aqueous and PBS media is confirmed by the increase in the degree of fluorescence anisotropy (r) of these binary systems. In an aqueous solution, the value of r for the RB-F108-CS system decreases by a factor of 3.5 (compared to the value of r for the RB-CS system), which is associated with the localization of the dye in pluronic micelles. In PBS, the fluorescence anisotropy is practically the same for all systems, which is related to the stability of the dye structure in this medium. The presence of interaction between RB and AP in aqueous solutions was confirmed by the proton NMR method. In addition, the formation of RB-F108 macromolecular complexes, which form associates during solution concentration (in particular, during evaporation), was shown by AFM. Such RB-AP-CS systems may be promising for practical application in the treatment of local foci of infections by aPDT.

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Antimicrobial photodynamic therapy against Propionibacterium acnes biofilms using hypericin (Hypericum perforatum) photosensitizer: in vitro study

Cited by 25 publications

References 33 publications

A narrative review of research progress on the role of NLRP3 inflammasome in acne vulgaris

A narrative review of research progress on the role of NLRP3 inflammasome in acne vulgaris

Antimicrobial Effect of Phytochemicals from Edible Plants

Effect of Chitosan and Amphiphilic Polymers on the Photosensitizing and Spectral Properties of Rose Bengal

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