Antimicrobial photodynamic therapy vs. local minocycline in addition to non-surgical therapy of deep periodontal pockets: a controlled randomized clinical trial

Tabenski, Laura; Moder, Daniel; Schenke, Frederike; Hiller, Karl‐Anton; Buchalla, Wolfgang; Schmalz, Gottfried; Christgau, M.

doi:10.1007/s00784-016-2018-6

Cited by 46 publications

(63 citation statements)

References 41 publications

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“…Of these 12 studies, a further six were excluded. After the final stage of selection, six studies were included and processed for data extraction (ĸ score for interassessor agreement at full‐text eligibility, ĸ = .96) . The study identification flowchart according to PRISMA, with reasons for exclusion of articles, is shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…Six RCT were included in the present review . The studies were carried out in Brazil, Saudi Arabia, Germany, India, and Iran .…”

Section: Resultsmentioning

confidence: 99%

“…Six RCT were included in the present review . The studies were carried out in Brazil, Saudi Arabia, Germany, India, and Iran . In all studies, the number of participants ranged between 52 and 30 individuals, with the mean age ranging between 30.6 and 51.84 years .…”

Section: Resultsmentioning

confidence: 99%

“…The studies were carried out in Brazil, Saudi Arabia, Germany, India, and Iran . In all studies, the number of participants ranged between 52 and 30 individuals, with the mean age ranging between 30.6 and 51.84 years . All studies reported the percentage of female participants, which ranged between 15% and 90% .…”

Section: Resultsmentioning

confidence: 99%

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How effective is adjunctive antimicrobial photodynamic therapy in treating deep periodontal pockets in periodontal disease? A systematic review

Akram

2018

J of Invest & Clin Dent

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The aim of the present systematic review was to evaluate the efficacy of antimicrobial photodynamic therapy (aPDT) that is used as an adjunctive therapy with scaling and root planing (SRP) in deep periodontal pockets (≥5 mm). The addressed Patients, Intervention, Comparators, Outcomes, and Study design question was: In patients with advanced periodontitis (population), what is the effect of aPDT as adjunct to SRP (intervention) in comparison to SRP alone (comparison) on deep probing depths (outcome)? Electronic and manual literature searches were conducted using the following databases: MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and Cochrane Oral Health Group Trials Register, up to and including February 2018. Six randomized trials were included. All studies used the combined approach aPDT+SRP and SRP in the test and control groups, respectively. The follow-up period ranged from 12 to 48 weeks. Wavelengths, power density, and duration of irradiation used were 670 nm, 500 mW cm , and 60 seconds, respectively. All studies showed significant reduction of probing depth (PD) ≥5 mm with aPDT at follow up. Considering the effects of adjunctive aPDT compared to SRP, only two studies showed additional benefit of adjunctive aPDT in reducing PD ≥5 mm compared to SRP alone at follow up. The overall mean difference for PD reduction (weighted mean difference = 0.31, 95% confidence interval [CI] = -0.03 to -0.66, P = .08) was also not significant between the aPDT and SRP groups at follow up. Whether aPDT as an adjunct to SRP is efficacious in the reduction of PD ≥5 mm compared to SRP alone in periodontal disease remains debatable, given that the available scientific evidence is weak.

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Section: Resultsmentioning

confidence: 99%

“…Six RCT were included in the present review . The studies were carried out in Brazil, Saudi Arabia, Germany, India, and Iran .…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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How effective is adjunctive antimicrobial photodynamic therapy in treating deep periodontal pockets in periodontal disease? A systematic review

Akram

2018

J of Invest & Clin Dent

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“…Tabenski et al 27) in press CP ( • Higher reductions of relative proportions of red complex bacteria were observed in a-PDT compared to SRP group.…”

Section: Srp (30) Srp (Us/h)mentioning

confidence: 94%

Application of Antimicrobial Photodynamic Therapy in Dental Treatments

Takeuchi

Aoki

Hiratsuka

et al. 2018

JJSLSM

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Removal of dental plaque and/or carious dentine has been conventionally performed by mechanical instrumentations. In recent years, an application of antimicrobial photodynamic therapy (a-PDT) using diode laser or LED lights together with dye as photosensitizer has been proposed and studied to use dental treatments. In this communication, an application of a-PDT, for the treatments of dental caries and periodontal diseases which are two major oral diseases, is discussed based on the current basic and clinical studies. We also introduce current our studies focused on the application of a-PDT in periodontal treatments.

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Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri-implant diseases

Jervøe-Storm,

Bunke,

Worthington

et al. 2024

Cochrane Database of Systematic Reviews

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Antimicrobial photodynamic therapy vs. local minocycline in addition to non-surgical therapy of deep periodontal pockets: a controlled randomized clinical trial

Abstract: In deep periodontal defects, the efficacy of non-surgical periodontal treatment seems not to be improved by adjunctive use of antimicrobial photodynamic therapy or minocycline microspheres.

Cited by 46 publications

References 41 publications

How effective is adjunctive antimicrobial photodynamic therapy in treating deep periodontal pockets in periodontal disease? A systematic review

How effective is adjunctive antimicrobial photodynamic therapy in treating deep periodontal pockets in periodontal disease? A systematic review

Application of Antimicrobial Photodynamic Therapy in Dental Treatments

Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri-implant diseases

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