Antimicrobial photodynamic therapy with Bixa orellana extract and blue LED in the reduction of halitosis—A randomized, controlled clinical trial

Gonçalves, Marcela Letícia Leal; Mota, Ana Carolina Costa da; Deana, Alessandro Melo; Cavalcante, Lisyanne Araújo de Souza; Horliana, Anna Carolina Ratto Tempestini; Pavani, Christiane; Motta, Lara Jansiski; Fernandes, Kristianne Porta Santos; Mesquita‐Ferrari, Raquel Agnelli; Silva, Daniela de Fátima Teixeira da; Motta, Pamella de Barros; Prates, Renato Araújo; Bussadori, Sandra Kalil

doi:10.1016/j.pdpdt.2020.101751

Cited by 26 publications

(28 citation statements)

References 27 publications

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“…Gonçalves et al [ 111 ] studied the effects of a Bixa orellana extract on Gram-negative biofilms, and performed clinical studies and reported that 20 s of exposure to 1540 W/m 2 light with the extract reduced halitosis in a clinical trial. Andreazza et al [ 110 ] investigated APDT using a Guatteria blepharophylla extract to control a broad range of microorganisms.…”

Section: Natural Pss In Apdtmentioning

confidence: 99%

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

2021

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Health problems and reduced treatment effectiveness due to antimicrobial resistance have become important global problems and are important factors that negatively affect life expectancy. Antimicrobial photodynamic therapy (APDT) is constantly evolving and can minimize this antimicrobial resistance problem. Reactive oxygen species produced when nontoxic photosensitizers are exposed to light are the main functional components of APDT responsible for microbial destruction; therefore, APDT has a broad spectrum of target pathogens, such as bacteria, fungi, and viruses. Various photosensitizers, including natural extracts, compounds, and their synthetic derivatives, are being investigated. The main limitations, such as weak antimicrobial activity against Gram-negative bacteria, solubility, specificity, and cost, encourage the exploration of new photosensitizer candidates. Many additional methods, such as cell surface engineering, cotreatment with membrane-damaging agents, nanotechnology, computational simulation, and sonodynamic therapy, are also being investigated to develop novel APDT methods with improved properties. In this review, we summarize APDT research, focusing on natural photosensitizers used in in vitro and in vivo experimental models. In addition, we describe the limitations observed for natural photosensitizers and the methods developed to counter those limitations with emerging technologies.

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Section: Natural Pss In Apdtmentioning

confidence: 99%

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

2021

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“…The fact that the urucum is red facilitates the work combined with LED and enables its use on a larger scale, as the majority of dentists already have blue LEDs at their offices. The protocol with urucum and LED has already been used and shown good clinical results in the immediate reduction of halitosis [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…For aPDT, urucum will be used as photosensitizer (PS), associated with a blue LED, following an already published protocol [28]. The absorbance of urucum has been tested in a previous study by Gonçalves et al [29] and it showed a peak of absorption close to the 460nm (ffi400nm-510nm), which is one of the peaks of wavelength generated by the LED that will be used in this study. In addition to that, it has been shown that the urucum generates singlet oxygen when irradiated with a blue light in a dose-dependent manner, i.e., the higher the concentration the extract, the greater is the production of singlet oxygen, which is necessary for PDT.…”

Section: Antimicrobial Photodynamic Therapymentioning

confidence: 99%

Comparative study between photodynamic therapy with urucum + Led and probiotics in halitosis reduction–protocol for a controlled clinical trial

Motta

Mota

et al. 2021

PLoS ONE

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Background Halitosis is a term that defines any foul odor emanating from the oral cavity. The origin may be local or systemic. The aim of the proposed protocol is to determine whether treatment with antimicrobial photodynamic therapy (aPDT) and treatment with probiotics are effective at eliminating halitosis. Materials and methods Eighty-eight patients, from 18 to 25 years old with a diagnosis of halitosis (H2S≥112 ppb, determined by gas chromatography) will be randomly allocated to four groups (n = 22) that will receive different treatments: Group 1 –treatment with teeth brushing, dental floss and tongue scraper; Group 2 –brushing, dental floss and aPDT; Group 3 –brushing, dental floss and probiotics; Group 4 –brushing, flossing, aPDT and probiotics. The results of the halimetry will be compared before, immediately after, seven days and thirty days after treatment. The microbiological analysis of the coated tongue will be performed at these same times. The normality of the data will be determined using the Shapiro-Wilk test. Data with normal distribution will be analyzed using analysis of variance (ANOVA). Non-parametric data will be analyzed using the Kruskal-Wallis test. The Wilcoxon test will be used to analyze the results of each treatment at the different evaluation periods. Clinical trail registration NCT03996044.

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“…In another study, a red LED diode was used, thanks to which the number of irradiated points was reduced to four, and the PDT was immediately effective in reducing the emission of hydrogen sulfide from the oral cavity to a level consistent with the absence of halitosis, but the effect did not last after 7, 14, and 30 days of observation, nor did it cause a reduction in the numbers of Porphyromonas gingivalis , Treponema denticola , and Tannerella forsythia [ 30 ]. The effectiveness of photodynamic therapy using a blue LED in combination with Bixa orellana extract has also been tested, and appears to be effective in reducing halitosis immediately; however, similarly to the above-mentioned studies, this effect was not maintained in the seven-day control [ 31 ].…”

Section: Treatment Of Halitosismentioning

confidence: 99%

The Problem of Halitosis in Prosthetic Dentistry, and New Approaches to Its Treatment: A Literature Review

Wyszyńska

Nitsze-Wierzba

Białożyt-Bujak

et al. 2021

JCM

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The aim of this work is a review of recent information about halitosis among patients using prosthetic dentures. Halitosis is a condition in which an unpleasant smell comes out of the oral cavity, which is caused mainly by volatile sulfur and non-sulfured compounds. The etiology of halitosis may be intra- or extra-oral; in most patients, however, it is due to the activity of microorganisms in the oral cavity. The problem of the occurrence of halitosis has accompanied patients for many years. In dental prosthetics, the problem of halitosis occurs in patients using removable or fixed dentures. In both cases, new niches for the development of microorganisms may be created, including those related to halitosis. It should be noted that dentures—both fixed and removable—are a foreign body placed in the patient’s oral cavity which, in case of insufficient hygiene, may constitute a reservoir of microorganisms, causing this unpleasant condition. Conventional treatment of intraoral halitosis reduces microbial activity via chemical and/or mechanical action. Currently, the search for new strategies in the treatment of halitosis is in progress. One idea is to use photodynamic therapy, while another is to modify poly(methyl methacrylate) (PMMA) with silver and graphene nanoparticles. Additionally, attempts have been made to combine those two methods. Another unconventional method of treating halitosis is the use of probiotics.

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Antimicrobial photodynamic therapy with Bixa orellana extract and blue LED in the reduction of halitosis—A randomized, controlled clinical trial

Cited by 26 publications

References 27 publications

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Comparative study between photodynamic therapy with urucum + Led and probiotics in halitosis reduction–protocol for a controlled clinical trial

The Problem of Halitosis in Prosthetic Dentistry, and New Approaches to Its Treatment: A Literature Review

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