Antimicrobial polymeric composites for high-touch surfaces in healthcare applications

Liu, Minghui; Bauman, Lukas; Nogueira, Christiane Lourenço; Aucoin, Marc G.; Anderson, William A.; Zhao, Boxin

doi:10.1016/j.cobme.2022.100395

Cited by 21 publications

(9 citation statements)

References 59 publications

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“…There are some recent literature reviews on the application of polymer-matrix metal oxide nanocomposites as self-sterilizing antimicrobial surfaces in healthcare environments which will not be repeated here [ 268 , 269 , 270 ]. The antibacterial and photosensitizing activity of ZnO nanoparticles has been well exploited in the absence or presence of light irradiation [ 271 ].…”

Section: Nanocomposite/nanohybrid Antibacterial Materialsmentioning

confidence: 99%

Recent Advances in the Development of Lipid-, Metal-, Carbon-, and Polymer-Based Nanomaterials for Antibacterial Applications

Ren

Lim

et al. 2022

Nanomaterials

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Infections caused by multidrug-resistant (MDR) bacteria are becoming a serious threat to public health worldwide. With an ever-reducing pipeline of last-resort drugs further complicating the current dire situation arising due to antibiotic resistance, there has never been a greater urgency to attempt to discover potential new antibiotics. The use of nanotechnology, encompassing a broad range of organic and inorganic nanomaterials, offers promising solutions. Organic nanomaterials, including lipid-, polymer-, and carbon-based nanomaterials, have inherent antibacterial activity or can act as nanocarriers in delivering antibacterial agents. Nanocarriers, owing to the protection and enhanced bioavailability of the encapsulated drugs, have the ability to enable an increased concentration of a drug to be delivered to an infected site and reduce the associated toxicity elsewhere. On the other hand, inorganic metal-based nanomaterials exhibit multivalent antibacterial mechanisms that combat MDR bacteria effectively and reduce the occurrence of bacterial resistance. These nanomaterials have great potential for the prevention and treatment of MDR bacterial infection. Recent advances in the field of nanotechnology are enabling researchers to utilize nanomaterial building blocks in intriguing ways to create multi-functional nanocomposite materials. These nanocomposite materials, formed by lipid-, polymer-, carbon-, and metal-based nanomaterial building blocks, have opened a new avenue for researchers due to the unprecedented physiochemical properties and enhanced antibacterial activities being observed when compared to their mono-constituent parts. This review covers the latest advances of nanotechnologies used in the design and development of nano- and nanocomposite materials to fight MDR bacteria with different purposes. Our aim is to discuss and summarize these recently established nanomaterials and the respective nanocomposites, their current application, and challenges for use in applications treating MDR bacteria. In addition, we discuss the prospects for antimicrobial nanomaterials and look forward to further develop these materials, emphasizing their potential for clinical translation.

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Section: Nanocomposite/nanohybrid Antibacterial Materialsmentioning

confidence: 99%

Recent Advances in the Development of Lipid-, Metal-, Carbon-, and Polymer-Based Nanomaterials for Antibacterial Applications

Ren

Lim

et al. 2022

Nanomaterials

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“…17 Polymers can prevent attachment, growth and biofilm formation of bacteria on surfaces, due to their intrinsic antimicrobial properties or by incorporation of antimicrobial additives thereby minimizing the risk of infections. 18,19 In this way, antimicrobial polymers can be incorporated in medical, industrial, public and private settings to provide biocidal effects without any release of biocidal substances into the environment. 20 Amongst the means of incorporating antimicrobial agents on surfaces, surface functionalization techniques and development of polymer brushes from surface-initiated polymerizations is the most popular technique and it greatly improves biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of cross‐linked diazaborine‐based polymeric microparticles with antiquorum sensing, anti‐swarming, antimicrobial, and antibiofilm properties

Tamfu

Koçak

Ceylan

et al. 2023

J of Applied Polymer Sci

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Transmission of infectious diseases and resistance by microorganisms is a global health threat. Antimicrobial polymers are increasingly being developed as biocides with greater applications than traditional antibiotics. In this study, 3‐(potassiumsulfonyl)propyl methacrylate (SPMA) monomer, ethylene glycol dimethacrylate cross‐linker and ammonium persulfate initiator were reacted to yield poly[3‐(potassiumsulfonyl)propyl methacrylate] microgels (PSPMA). Surface modification of PSPMA with thionyl chloride yielded poly[3‐(chlorosulfonyl)propyl methacrylate microparticle] (PSPMA‐Cl) which was reacted with hydrazinehydrate to obtain poly[3‐(hydrazinylsulfonyl)propyl methacrylate] microparticles (PSPMA‐NH2). Finally, 2‐formyl benzeneboronic acid was added to give the final product poly[3‐((1‐hydroxybenzo(d)(1,2,3)diazaborinin‐2(1H)‐yl)sulfonyl)propyl methacrylate] (PSPMA‐DAZ) microparticles. The modified microparticles were characterized using attenuated total reflectance‐Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy and energy‐dispersive x‐ray analyses. The polymeric microparticles showed good antibiofilm activity against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Candida albicans ATCC 10239 and Candida tropicalis ATCC 13803 while low to moderate biofilm inhibitions were observed against Listeria monocytogenes ATCC 7644, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853 and Salmonella typhi ATCC 14028. Surface group modification from PSPMA, PSPMA‐Cl, PSPMA‐NH2 to PSPMA‐DAZ increased violacein inhibition, quorum‐sensing inhibition and antimicrobial activity but reduced swarming. These polymer microparticles can be used to reduce spread of microbial infections and resistance.

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“…Additionally, the polymers can act as a matrix for the materials holding antimicrobial agents, thus leading to the development of new materials, which are both bactericidal and biocompatible. Moreover, antimicrobial polymers usually have a longer-term activity [ 12 , 13 , 14 , 15 , 16 ]. Thus, systems based on the combination of polymer and inorganic/organic antimicrobial agents present a special interest.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Materials Based on Hydroxypropyl Methylcellulose and Silver Nanoparticles: Structural-Morphological Characterization and Antimicrobial Testing

Filimon¹,

Onofrei²,

Bargan³

et al. 2023

Polymers

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The progress achieved in recent years in the biomedical field justifies the objective evaluation of new techniques and materials obtained by using silver in different forms as metallic silver, silver salts, and nanoparticles. Thus, the antibacterial, antiviral, antifungal, antioxidant, and anti-inflammatory activity of silver nanoparticles (AgNPs) confers to newly obtained materials characteristics that make them ideal candidates in a wide spectrum of applications. In the present study, the use of hydroxypropyl methyl cellulose (HPMC) in the new formulation, by embedding AgNPs with antibacterial activity, using poly(N-vinylpyrrolidone) (PVP) as a stabilizing agent was investigated. AgNPs were incorporated in HPMC solutions, by thermal reduction of silver ions to silver nanoparticles, using PVP as a stabilizer; a technique that ensures the efficiency and selectivity of the obtained materials. The rheological properties, morphology, in vitro antimicrobial activity, and stability/catching of Ag nanoparticles in resulting HPMC/PVP-AgNPs materials were evaluated. The obtained rheological parameters highlight the multifunctional roles of PVP, focusing on the stabilizing effect of new formulations but also the optimization of some properties of the studied materials. The silver amount was quantified using the spectroscopy techniques (energy-dispersive X-ray fluorescence (XRF), energy-dispersive X-ray spectroscopy (EDX)), while formation of the AgNPs was confirmed using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Also, the morphological examination (Atomic Force Microscopy (AFM) and Scanning electron microscopy (SEM)) by means of the texture roughness parameters has evidenced favorable characteristics for targeted applications. Antibacterial activity was tested against Escherichia coli and Staphylococcus aureus and was found to be substantially improved was silver was added in the studied systems.

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Antimicrobial polymeric composites for high-touch surfaces in healthcare applications

Cited by 21 publications

References 59 publications

Recent Advances in the Development of Lipid-, Metal-, Carbon-, and Polymer-Based Nanomaterials for Antibacterial Applications

Recent Advances in the Development of Lipid-, Metal-, Carbon-, and Polymer-Based Nanomaterials for Antibacterial Applications

Synthesis of cross‐linked diazaborine‐based polymeric microparticles with antiquorum sensing, anti‐swarming, antimicrobial, and antibiofilm properties

Bioactive Materials Based on Hydroxypropyl Methylcellulose and Silver Nanoparticles: Structural-Morphological Characterization and Antimicrobial Testing

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