Antimicrobial potential of bacteriocins: in therapy, agriculture and food preservation

Ahmad, Varish; Khan, Mohd Sajid; Jamal, Qazi Mohammad Sajid; Alzohairy, Mohammad A.; Karaawi, Mohammad A. Al; Siddiqui, Mughees Uddin

doi:10.1016/j.ijantimicag.2016.08.016

Cited by 239 publications

(158 citation statements)

References 161 publications

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“…We reviewed herein the potential of AMPs for application to antitumor therapy as anticancer peptides (ACPs) with novel mechanisms. Broad structural and functional properties of AMPs not pertaining to selective action against cancer cells and antitumor efficacy are reviewed elsewhere [32–39]. …”

Section: Introductionmentioning

confidence: 99%

Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications

2017

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In the last several decades, there have been significant advances in anticancer therapy. However, the development of resistance to cancer drugs and the lack of specificity related to actively dividing cells leading to toxic side effects have undermined these achievements. As a result, there is considerable interest in alternative drugs with novel antitumor mechanisms. In addition to the recent approach using immunotherapy, an effective but much cheaper therapeutic option of pharmaceutical drugs would still provide the best choice for cancer patients as the first line treatment. Ribosomally synthesized cationic antimicrobial peptides (AMPs) or host defense peptides (HDP) display broad-spectrum activity against bacteria based on electrostatic interactions with negatively charged lipids on the bacterial surface. Because of increased proportions of phosphatidylserine (negatively charged) on the surface of cancer cells compared to normal cells, cationic amphipathic peptides could be an effective source of anticancer agents that are both selective and refractory to current resistance mechanisms. We reviewed herein the prospect for AMP application to cancer treatment, with a focus on modes of action of cationic AMPs.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications

2017

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“…Many LAB naturally produce antimicrobial peptides, (e.g. bacteriocins), which have applications as bio-controlling agents and immunomodulators in the GIT and are currently commercialized in the purified form for veterinary use (Ahmad 2017). These compounds have demonstrated high specificity and potency in vivo and are a potential alternative to fight the raising of antimicrobial resistance (Behrens 2017).…”

Section: Agro-applicationsmentioning

confidence: 99%

High-throughput Genome Editing Tools for Lactic Acid Bacteria: Opportunities for Food, Feed, Pharma and Biotech

Ra¹,

Kandasamy²,

Am³

et al. 2018

Preprint

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This mini-review provides an overview of traditional, emerging, and future applications of lactic acid bacteria (LAB) and discusses how genome editing tools can be used to overcome current challenges in all these applications. It also describes currently available tools and how these can be further developed, and takes current legislation into account. Genome editing tools are necessary for the construction of strains for new applications and products, but can also play a crucial role in traditional ones, such as food and probiotics, as a research tool for understanding mechanistic insights and discovering new properties. Traditionally, recombinant DNA techniques for LAB have strongly focused on being food-grade, but they lack throughput and the number of genetically tractable strains is still rather limited. Further tool development in this direction will enable rapid construction of multiple mutants or mutant libraries on a genomic level in a wide variety of LAB strains. We also propose an iterative Design-Build-Test-Learn workflow cycle for LAB cell factory development based on systems biology, with “cell factory” expanding beyond its traditional meaning of production strains and making use of high-throughput genome editing tools to advance LAB understanding, applications and strain development.

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“…They are called bacteriocins and have been applied in foods susceptible to microalgal degradation aiming to promote food security [27]. The knowledge about bacterial fermentations is used for millennia, not only for development of food products with a peculiar flavor, but also to extend their shelf life, mainly by lactose conversion to lactic acid [28].…”

Section: Natural Preservativesmentioning

confidence: 99%

Can Microalgae Act as Source of Preservatives in Food Chain?

Scaglioni¹,

Badiale‐Furlong²

2017

JFSE

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Microalgae are a potential source for various valuable chemicals for commercial applications ranging from nutraceuticals to fuels. This review aims to focus on microalgal as preservative potential to food chain. The main compounds responsible for these properties, like carotenoids, phenolic compounds, antioxidant vitamins, sterols and polyunsaturated fatty acids are discussed because microalgae can be cultivated under controlled conditions to improve their production. We have listed several studies performed in recent years supporting the health benefits that most of these compounds can provide. Therefore, they may represent an excellent source of preservatives in food chain once their safety as a food supplement has been also confirmed.

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Antimicrobial potential of bacteriocins: in therapy, agriculture and food preservation

Cited by 239 publications

References 161 publications

Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications

Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications

High-throughput Genome Editing Tools for Lactic Acid Bacteria: Opportunities for Food, Feed, Pharma and Biotech

Can Microalgae Act as Source of Preservatives in Food Chain?

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