Antimicrobial potential of Dialium guineense (Wild.) stem bark on some clinical isolates in Nigeria

Olajubu, FA; Akpan, I.; Da, Ollo; Oluwalana, SA

doi:10.4103/2229-516x.96811

Cited by 17 publications

(8 citation statements)

References 9 publications

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“…However, there are some studies about the bioactivity of D. guineense, one of the other Dialium genus species. The bark extract of D. guineense exhibited antibacterial activity [3] , while the leaf extracts have antioxidant and antimicrobial activities [4] . The dichloromethane fraction of D. guineense fruit coat exerted wound-healing and antimicrobial properties [5] .…”

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confidence: 99%

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Evaluation of Antimicrobial, Antioxidant and Cytotoxic Activities of Dialium cochinchinensis Seed Extract

Bui¹,

Nguyen²,

Dao³

et al. 2019

ijps

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Bui et al.: Antimicrobial, antioxidant and cytotoxic activities of Dialium cochinchinensisThis study was undertaken to evaluate the phytoconstituents present in the seed extract of Dialium cochinchinensis for antioxidant, antimicrobial and cytotoxic properties. Results showed the presence of polyphenols, flavonoids, alkaloids, saponins, coumarins and a polyuronid compound in the Dialium cochinchinensis seed extract. The total polyphenol and flavonoid contents of the dry extract were 133.5±2.87 mg GAE/g and 227.0±23.20 mg rutin equivalent/g, respectively. Dialium cochinchinensis seed extract exhibited antioxidant property in 2,2-diphenyl-1-picrylhydrazyl, 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid and potassium ferricyanide reducing antioxidant power methods. Moreover, Dialium cochinchinensis seed extract exerted inhibitory effect on Gram-positive bacteria. Finally, Dialium cochinchinensis seed extract was found to be toxic to Vero cell lines and the pathogens with selectivity index ranging from 0.01 to 0.04. In conclusion, Dialium cochinchinensis seed extract could be considered as a new source of natural antioxidant and antimicrobial agents for research and application.

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confidence: 99%

“…The effectiveness of an antimicrobial agent is determined by its ability to inhibit or kill bacteria [3] . DCS extract showed strong inhibition effect on some bacteria tested.…”

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confidence: 99%

Evaluation of Antimicrobial, Antioxidant and Cytotoxic Activities of Dialium cochinchinensis Seed Extract

Bui¹,

Nguyen²,

Dao³

et al. 2019

ijps

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“…Its stem bark is used for the treatment of cough, toothache, and bronchitis [ 9 ]. Many studies have showed the antiulcer activity (leaves) [ 10 ], antimicrobial activity (fruits, leaves, roots, stem bark) [ 11 , 12 ], antivibrio activity (leaves) [ 13 ], antiplasmodium activity (leaves) [ 14 , 15 ], molluscicidal activity (fruit) [ 16 ], analgesic activity (bark) [ 17 ], antihepatotoxic activity (fruit pulp) [ 18 ], antidiarrheal activity (leaves) [ 19 ], and antioxidant activity (fruits; leaves, stem bark) [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Antidiarrheal Activity of Dialium guineense Willd Fruit Pulp in Wistar Rats

Assiki

Diallo

Badjabaissi

et al. 2022

BioMed Research International

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Objective. This study is aimed at evaluating the effects of Dialium guineense Willd fruit pulp powder on diarrhea induced by castor oil in Wistar rats. Materials and Methods. Three different tests were carried out. A preventive test by administration of a single dose of 250, 500, 1000, 2000, and 4000 mg/kg before the induction of diarrhea by castor oil. Another preventive test after repeated administration of Dialium guineense at 250, 500, and 1000 mg/kg/day for 8 days, before the induction of diarrhea, was done. The third test was a curative test with a single dose of 250, 500, 1000, and 2000 mg/kg after the induction of diarrhea by castor oil. Results. D. guineense fruit pulp at 1000, 2000, and 4000 mg/kg administered before the induction of diarrhea, has significantly delayed diarrhea; reduced the frequency of defecation, reduced the amount of diarrheal stools, and also reduced the purging index, with a degree of inhibition comparable to that of loperamide. But the water content of the stools of the group treated with D. guineense does not change significantly compared to the controls. D. guineense has reduced significantly from 500 mg/kg the diarrhea induced by castor oil after 8 days of treatment. It appears that the doses of 250 and 500 mg/kg, which were not effective with the single-dose preventive test, significantly delayed diarrhea; reduces the frequency of diarrheal stools and also reduces the purging index. D. guineense administered, after the induction of diarrhea, by castor oil has significantly reduced the diarrhea from 250 mg/kg. Conclusion. The fruit pulp of D. guineense has showed antidiarrheal activities in Wistar rats by reducing the frequency of defecation, the amount of diarrheal fecal matter emitted as well as the water content. It also delayed the onset of diarrhea and significantly reduced the purging index like loperamide.

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“…Although World Health Organization announced that governments ensure that all people have equitable access to the preventive, curative and rehabilitative health services they need to avoid developing high blood pressure and its complications, it is clear that the road ahead to achieve this goal is still long [1] . In spite of the increase of accessibility of modern medicine and the variety of drugs available for various ailments, it has been observed that 85% of patients combine herbal therapy with the medicines prescribed at hospitals or clinics [2] . The plant-derived remedies or recipes are widely used in all civilizations and cultures.…”

Section: Introductionmentioning

confidence: 99%

Antihypertensive effect of Dialium guineense Wild. and Trema orientalis L. in L-NAME-induced hypertensive rats

Adjileye¹,

Amoussa²,

Adamou³

et al. 2020

J Phytopharmacol

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Dialium guineense (Caesalpiniaceae) and Trema orientalis (Celtidaceae) are traditionally used to treat and manage many diseases such as hypertension, headache and diabetes. Despite their recognized efficacy in traditional medicine, their antihypertensive properties are not yet effective. Therefore, the current study aimed to investigate the antihypertensive effect of ethanolic extracts of Dialium guineense and Trema orientalis on L-NAME-induced hypertensive rats. The systolic, diastolic and mean arterial pressure were recorded using CODA™ non-invasive blood pressure system. The phenolic compounds were also quantified using High Pressure Liquid Chromatography. Ethanolic extracts of both plants induced significant decrease of mean arterial pressure. At 500 mg/kg bw, both plants decreased mean arterial pressure from 126.4 ± 0.48 to 90.6 ± 3.12 mmHg and from 154.8 ± 7.84 to 103 ± 5.6 mmHg respectively for Dialium guineense and Trema orientalis. Losartan and Captopril, used as standard drugs at 100 mg/kg body weight, also significantly decrease blood pressure. Trema orientalis was the most active with a blood pressure reduction percentage of 33.46 ± 3.06 % comparable to Losartan (31.37 ± 3.13 %) and Captopril (31.76 ± 2.63 %). The probable bioctives compound identified were chlorogenic, gallic, caffeic, ellargic, tannic acids, and luteolin, isorhamnetin and chrysin.

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Antimicrobial potential of Dialium guineense (Wild.) stem bark on some clinical isolates in Nigeria

Cited by 17 publications

References 9 publications

Evaluation of Antimicrobial, Antioxidant and Cytotoxic Activities of Dialium cochinchinensis Seed Extract

Evaluation of Antimicrobial, Antioxidant and Cytotoxic Activities of Dialium cochinchinensis Seed Extract

Antidiarrheal Activity of Dialium guineense Willd Fruit Pulp in Wistar Rats

Antihypertensive effect of Dialium guineense Wild. and Trema orientalis L. in L-NAME-induced hypertensive rats

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