Antimicrobial potential of Glycyrrhiza glabra roots

Gupta, Vivek Kumar; Fatima, Atiya; Faridi, Uzma; Negi, Arvind S.; Shanker, Karuna; Kumar, Jonnala Kotesh; Rahuja, Neha; Luqman, Suaib; Sisodia, Brijesh S.; Saikia, Dharmendra; Darokar, Mahendra P.; Khanuja, S. P. S.

doi:10.1016/j.jep.2007.11.037

Cited by 204 publications

(125 citation statements)

References 26 publications

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“…Al-Bachir and Al-Adawi [34] reported relatively high total aerobic plate counts, including coliform, E. coli and Klebsiella spp., after treatment with licorice roots powder. Gupta et al [14] also found that the root extracts of G. glabra showed activity against Mycobacterium tuberculosis H 37 Ra and H 37 Rv at a concentration of 500 mg/mL.…”

Section: Antimicrobial Activitymentioning

confidence: 96%

“…[12,13] Licorice root extracts have been shown to be beneficial in the treatment of eye diseases, throat infections, peptic ulcers, liver diseases, joint diseases, arthritic conditions, immunodeficiency, [14] cough, tuberculosis, respiratory diseases, cancer, diabetes, endocrine disorders, [15] kidney diseases, [16] bronchitis, asthma, psoriasis, eczema, haemorrhoids, [17] epilepsy, chronic hepatitis, heart diseases [3] and orodental diseases. [18] It has also been shown that extracts help regulate the estrogenÀprogesterone ratio [19À21] and the gastrointestinal system.…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial and antioxidant activities of medicinal plant Glycyrrhiza glabra var. glandulifera from different habitats

Karahan

Avşar

Özyiğit

et al. 2016

Biotechnology & Biotechnological Equipment

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In this study, the antimicrobial and antioxidant activities of root methanolic extracts of Glycyrrhiza glabra var. glandulifera (Waldst. & Kit.) Boiss. (Fabaceae) were investigated. Plant samples were collected from different habitats in the East Mediterranean part of Turkey. The plant extracts were evaluated for antimicrobial activities against nine bacterial and two yeast strains using discdiffusion and minimum inhibitory concentration methods. The antioxidant activity was determined by using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The antimicrobial assays indicated that the plant root extracts were more effective against Gram-positive bacteria than against Gramnegative ones. In addition, the extracts had higher antimicrobial effect against Candida species than against bacteria. The extracts showed good antioxidant activity, with a median inhibitory concentration (IC 50 ) in the range of 588 § 0.86 mg/mL to 2190 § 1.73 mg/mL. Results indicated that different environmental conditions in each habitat might affect the contents of chemical compounds and biological activity in the natural licorice populations of. This study also supported the traditional use of licorice and as well as suggested that it may also be its beneficial role in the treatment of other infections. The obtained results indicated that different environmental conditions in each habitat might affect the contents of chemical compounds and the biological activity in the natural licorice populations.

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Section: Antimicrobial Activitymentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Antimicrobial and antioxidant activities of medicinal plant Glycyrrhiza glabra var. glandulifera from different habitats

Karahan

Avşar

Özyiğit

et al. 2016

Biotechnology & Biotechnological Equipment

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“…Glycyrrhizin, a triterpenoid glycoside and glycyrrihizic acid isolated from GGL roots has been reported to have anti-viral activities against encephalitis virus and herpes simplex virus, respectively [24,71]. Alcoholic extract from the roots of GGL also possessed different health beneficial effects including antimicrobial activities [72,73], anti-oxidant activity [74], anti-angiogenic activities [75] and also actively worked against Mycobacterium tuberculosis [76].…”

mentioning

confidence: 99%

Exploration of the in vitro cytotoxic and antiviral activities of different medicinal plants against infectious bursal disease (IBD) virus

et al. 2014

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Infectious bursal disease (IBD) caused by non-enveloped double stranded RNA virus is an acute and contagious poultry disease. Outbreak of IBD could result in 10-75% mortality of the birds; hence it has gained socio-economic importance worldwide. Medicinal plants have shown broad spectrum anti-viral activities against RNA and DNA viruses. Moringa oleifera Lam (MOL), Phyllanthus emblicus Linn (PEL), Glycyrrhiza glabra Linn (GGL), and Eugenia jambolana Lam (EJL) are commonly available medicinal plants of the sub-continent and exhibited anti-viral potential against different viruses. Ethanolic extracts of the leaves of MOL and EJL, roots of GGL and dried fruit of PEL were investigated for their cytotoxic and anti-viral potential against IBD virus using MTT colorimetric assay and anti-viral assay. Significant anti-viral potential (P<0.001) was demonstrated at concentrations 12.5, 25, 50 and 100 µg ml -1 of GGL, PEL, MOL and EJL, respectively, with no cytotoxicity. Data also spotlighted that all tested plant extracts possess significant anti-viral potential and this trend was higher in GGL followed by PEL, MOL, and EJL. The data undoubtedly conclude that these medicinal plants contain several health beneficial phyto-chemicals which got significant anti-viral potential and effectively be utilized against IBD virus. Moreover, the outcomes of this study provide a platform on the way to discover novel anti-viral agents against IBD virus and other viruses from plant origin.

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“…Glycyrrhiza glabra L. has been used since long in indigenous medicine system either alone or with the combination of other drug plant materials. The antimicrobial activity of G. glabra against Mycobacterium tuberculosis has been established (Gupta et al, 2008). Licorice extracts have been used for more than 60 years in Japan to treat chronic hepatitis and also have therapeutic benefits against other viruses, including human immunodeficiency virus (HIV), cytomegalovirus (CMV) and Herpes simplex.…”

Section: Ansfmentioning

confidence: 99%

Antibacterial activity of Glycyrrhiza glabra roots against certain gram-positive and gram-negative bacterial strains

Gupta

Maheshwari

Khandelwal

2013

JANS

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Abstract:The present study aimed to evaluate the antibacterial potency of grinded crude material (root of Glycyrrhiza glabra) against some gram-positive and gram-negative bacterial strains. Two solvents (methanol and acetone) were used to extract the phytochemicals from the test material. Four different concentrations (100%, 75%, 50% and 25%) of methanolic and acetonic extract were used to investigate the inhibiting properties against Salmonella typhi, Escherichia.coli, Vibrio cholerae, Staphylococcus aureus, Bacillus cereus and Bacillus subtilis strains. Among methanol and acetone extracts, later exhibited low antibacterial activity. The 100% (w/v) concentration of both extracts showed maximum inhibition against B. subtilis followed by E. coli, S. aureus, B. cereus, S. typhi and V. Cholerae. Maximum activity in acetonic extract was obtained against B. cereus followed by S. typhi, E. coli, V. cholerae and S .aureus and minimum in B. subtilis. A reverse pattern of inhibition activity was found in both extacts (methanolic and acetonic) against B. subtilis. Maximum activity was found in methanolic extract against B. subtilis (18.6 mm) but it was only 14.3 mm against this strain in acetonic extract. The antibacterial activity of the crude samples corresponded to that of concentration. Hence there was positive correlation of antibacterial activity with the test material.

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Antimicrobial potential of Glycyrrhiza glabra roots

Cited by 204 publications

References 26 publications

Antimicrobial and antioxidant activities of medicinal plant Glycyrrhiza glabra var. glandulifera from different habitats

Antimicrobial and antioxidant activities of medicinal plant Glycyrrhiza glabra var. glandulifera from different habitats

Exploration of the in vitro cytotoxic and antiviral activities of different medicinal plants against infectious bursal disease (IBD) virus

Antibacterial activity of Glycyrrhiza glabra roots against certain gram-positive and gram-negative bacterial strains

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