Antimicrobial potentials of natural products against multidrug resistance pathogens: a comprehensive review

Elmaidomy, Abeer H.; Shady, Nourhan Hisham; Abdeljawad, Khaled Mohamed; Elzamkan, Mohamed Badran; Helmy, Hussein Hykel; Tarshan, Emad Ashour; Adly, Abanoub Nabil; Hussien, Yasmin Hamdy; Sayed, Nesma Gamal; Zayed, Ahmed; Abdelmohsen, Usama Ramadan

doi:10.1039/d2ra04884a

Cited by 37 publications

(21 citation statements)

References 223 publications

(271 reference statements)

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Section: Uses Of G Parvifloramentioning

confidence: 99%

“…One of the most serious challenges is the rise of antibiotic-resistant pathogenic species [ 84 ]. Infections caused by multidrug-resistant (MDR) bacteria are becoming more common and pose a serious threat to global public health [ [84] , [85] , [86] ]. It significantly reduces the likelihood of successfully treating infections and increases morbidity and mortality associated with common bacterial diseases.…”

Section: Uses Of G Parvifloramentioning

confidence: 99%

See 1 more Smart Citation

Galinsoga parviflora (Cav.): A comprehensive review on ethnomedicinal, phytochemical and pharmacological studies

Ripanda¹,

Luanda²,

Sule³

et al. 2023

Heliyon

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Section: Uses Of G Parvifloramentioning

confidence: 99%

Section: Uses Of G Parvifloramentioning

confidence: 99%

Galinsoga parviflora (Cav.): A comprehensive review on ethnomedicinal, phytochemical and pharmacological studies

Ripanda¹,

Luanda²,

Sule³

et al. 2023

Heliyon

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“…2 Since the emergence of drug resistance, the scientific community and the pharmaceutical firms have looked up to natural resources to find novel medications to address this lethal threat. 3 The biotic community of the marine ecosystem is presumed to be a rich source of biochemicals with wide therapeutic applications. In earlier studies, many compounds like nigrospoxydons A -C, epoxydon, dehydroxychlorofusarielin B, penicipyrone, 7-oxobrefeldin A, spirodioxynaphthalene etc., have been isolated and characterised from marine fungi and bacteria with potential to treat various human ailments.…”

Section: Introductionmentioning

confidence: 99%

Isolation of Fungi from Mangrove Ecosystem of Mumbai and Evaluation of their Antibacterial Potential

Patankar¹,

Reshi²

2023

J. Pure Appl. Microbiol.

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In the current study, fungi from the mangrove ecosystem of Mumbai were isolated and their metabolites were screened for antibacterial potential. Two weeks old broth and mycelium were extracted using chloroform and methanol. Antibacterial property of solvent extracts was evaluated at various concentrations (2 – 10 µg/ml) against Staphylococcus aureus, Bacillus subtilis, Enterococcus faecium, Enterococcus faecalis, Klebsiella pneumonia and Escherichia coli, by well diffusion method. Fungi isolated were identified as Aspergillus niger, Aspergillus flavus, Trichoderma harzianum, Cylindrocladium scoparium and Colletotrichum wuxiense. Results revealed that broth solvent extracts of isolates inhibited the growth of all gram-positive test bacteria, chloroform broth extract of Cylindrocladium scoparium, Colletotrichum wuxiense and ethanolic broth extract of Aspergillus flavus, Trichoderma harzianum exhibited antibacterial potential against gram negative test organisms. Chloroform and ethanol mycelium extracts of Trichoderma harzianum and Aspergillus flavus, respectively, exhibited 100% growth inhibition potential against all test organisms. The current investigation endorses the potent secondary metabolism of the identified isolates and their potential to synthesise antibacterial compounds.

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“…[8,9] Further, the emergence of antimicrobial resistance exacerbates the difficulty in treating PJI. [10,11] As the demand for primary and revision joint surgeries continues to rise at an accelerated rate, [5,12,13] an increasing future PJI burden is anticipated, which will have significant healthcare and economic implications. However, efficacious approaches to prevent and treat PJI and its recurrence remain elusive, predominantly due to bacterial adhesion, and subsequent biofilm formation on the implant and surrounding tissue surfaces.…”

Section: Introductionmentioning

confidence: 99%

Extracellular Proteins Isolated from L. acidophilus as an Osteomicrobiological Therapeutic Agent to Reduce Pathogenic Biofilm Formation, Regulate Chronic Inflammation, and Augment Bone Formation In Vitro

Pugazhendhi,

Seal,

Hughes

et al. 2023

Adv Healthcare Materials

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Periprosthetic joint infection (PJI) is a challenging complication that can occur following joint replacement surgery. Efficacious strategies to prevent and treat PJI and its recurrence remain elusive. Commensal bacteria within the gut convey beneficial effects through a defense strategy named “colonization resistance” thereby preventing pathogenic infection along the intestinal surface. This blueprint may be applicable to PJI. The aim is to investigate Lactobacillus acidophilus spp. and their isolated extracellular‐derived proteins (LaEPs) on PJI‐relevant Staphylococcus aureus, methicillin‐resistant S. aureus, and Escherichia coli planktonic growth and biofilm formation in vitro. The effect of LaEPs on cultured macrophages and osteogenic, and adipogenic human bone marrow‐derived mesenchymal stem cell differentiation is analyzed. Data show electrostatically‐induced probiotic‐pathogen species co‐aggregation and pathogenic growth inhibition together with LaEP‐induced biofilm prevention. LaEPs prime macrophages for enhanced microbial phagocytosis via cathepsin K, reduce lipopolysaccharide‐induced DNA damage and receptor activator nuclear factor‐kappa B ligand expression, and promote a reparative M2 macrophage morphology under chronic inflammatory conditions. LaEPs also significantly augment bone deposition while abating adipogenesis thus holding promise as a potential multimodal therapeutic strategy. Proteomic analyses highlight high abundance of lysyl endopeptidase, and urocanate reductase. Further, in vivo analyses are warranted to elucidate their role in the prevention and treatment of PJIs.

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Antimicrobial potentials of natural products against multidrug resistance pathogens: a comprehensive review

Abstract: Antibiotic resistance is one of the critical health issues, describing a significant social health complication globally.

Cited by 37 publications

References 223 publications

Galinsoga parviflora (Cav.): A comprehensive review on ethnomedicinal, phytochemical and pharmacological studies

Galinsoga parviflora (Cav.): A comprehensive review on ethnomedicinal, phytochemical and pharmacological studies

Isolation of Fungi from Mangrove Ecosystem of Mumbai and Evaluation of their Antibacterial Potential

Extracellular Proteins Isolated from L. acidophilus as an Osteomicrobiological Therapeutic Agent to Reduce Pathogenic Biofilm Formation, Regulate Chronic Inflammation, and Augment Bone Formation In Vitro

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