Antimicrobial Profile and Antibiotic Susceptibility of Neonatal Sepsis in Neonatal Intensive Care Unit of Tertiary Care Hospital of North India

Chauhan, Rahul; Gupta, Surbhi; Dalal, Poonam; Jhajra, Sandeep; Gathwala, Geeta

doi:10.5958/0976-5506.2019.01976.4

Cited by 2 publications

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“…Henceforth, it is important to discover the sensitivity of the responsible pathogens in order to define the empiric antibiotic regimens. 4,11,12 We wanted to determine the most frequent micro-organisms responsible for the neonatal nosocomial sepsis and to determine their resistance and sensitivity pattern to regularly used antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Neonatal nosocomial sepsis in Level-III NICU: Causative pathogens and their antimicrobial sensitivity.

Naz

Saleem

Khurshid³

et al. 2022

TPMJ

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Objective: To find out common organism causing nosocomial sepsis in neonatal intensive care unit (NICU) and their sensitivity to frequently used antibiotics. Study Design: Cross Sectional study. Setting: NICU Pediatric Department of Nishtar Hospital Multan. Period: May 2018 to April 2019. Material & Methods: A total of 111 neonates of either gender admitted with blood culture proven sepsis were included in the study. For culture, blood samples were taken, ensuring standard antiseptic measures, either from a peripheral vein or an artery. Any growth of bacteria after incubation of 24 to 48 hours with only BACTEC and VITEK-2 technique were included, and their drug sensitivity recorded. Demographic data along with causative microorganisms, sensitivity and resistant patterns to frequently used drugs were recorded. Results: Out of 111 patients, 61 (55%) were male. Early onset sepsis (EOS) was present in 37 (33%) patients and 74 (66%) had late onset sepsis (LOS). Serratia species 33 (29.7%) and Staphylococcus epidermidis 31 (27.9%) were the commonest causative bacteria responsible for neonatal sepsis. Commonly involved microorganisms were highly resistant to frequently used antibiotics like ampicillin /amoxicillin, cefixime, ceftazidime. Conclusion: Nosocomial sepsis is a major health issue in NICU while and resistance of pathogens to commonly used antibiotics is alarming.

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Section: Introductionmentioning

confidence: 99%

Neonatal nosocomial sepsis in Level-III NICU: Causative pathogens and their antimicrobial sensitivity.

Naz

Saleem

Khurshid³

et al. 2022

TPMJ

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Beyond Early- and Late-onset Neonatal Sepsis Definitions: What are the Current Causes of Neonatal Sepsis Globally? A Systematic Review and Meta-analysis of the Evidence

Harrison,

Dickson,

Sharland

et al. 2024

Pediatric Infectious Disease Journal

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Sepsis remains a leading cause of neonatal mortality, particularly in low- and lower-middle-income countries (LLMIC). In the context of rising antimicrobial resistance, the etiology of neonatal sepsis is evolving, potentially making currently-recommended empirical treatment guidelines less effective. We performed a systematic review and meta-analysis to evaluate the contemporary bacterial pathogens responsible for early-onset sepsis (EOS) and late-onset neonatal sepsis (LOS) to ascertain if historical classifications—that guide empirical therapy recommendations based on assumptions around causative pathogens—may be outdated. We analyzed 48 articles incorporating 757,427 blood and cerebrospinal fluid samples collected from 311,359 neonates across 25 countries, to evaluate 4347 significant bacteria in a random-effects meta-analysis. This revealed gram-negative bacteria were now the predominant cause of both EOS (53%, 2301/4347) and LOS (71%, 2765/3894) globally. In LLMICs, the predominant cause of EOS was Klebsiella spp. (31.7%, 95% CI: 24.1–39.7%) followed by Staphylococcus aureus (17.5%, 95% CI: 8.5 to 28.4%), in marked contrast to the Streptococcus agalactiae burden seen in high-income healthcare settings. Our results reveal clear evidence that the current definitions of EOS and LOS sepsis are outdated, particularly in LLMICs. These outdated definitions may be guiding inappropriate empirical antibiotic prescribing that inadequately covers the causative pathogens responsible for neonatal sepsis globally. Harmonizing sepsis definitions across neonates, children and adults will enable a more acurate comparison of the epidemiology of sepsis in each age group and will enhance knowledge regarding the true morbidity and mortality burden of neonatal sepsis.

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Antimicrobial Profile and Antibiotic Susceptibility of Neonatal Sepsis in Neonatal Intensive Care Unit of Tertiary Care Hospital of North India

Cited by 2 publications

References 0 publications

Neonatal nosocomial sepsis in Level-III NICU: Causative pathogens and their antimicrobial sensitivity.

Neonatal nosocomial sepsis in Level-III NICU: Causative pathogens and their antimicrobial sensitivity.

Beyond Early- and Late-onset Neonatal Sepsis Definitions: What are the Current Causes of Neonatal Sepsis Globally? A Systematic Review and Meta-analysis of the Evidence

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