Antimicrobial properties of co-doped tricalcium phosphates Ca3-2(MˊMˊˊ) (PO4)2 (M = Zn2+, Cu2+, Mn2+ and Sr2+)

Deyneko, Dina V.; Фадеева, И. В.; Borovikova, E. Yu.; Dzhevakov, Pavel B.; Slukin, Pavel V.; Zheng, Yufeng; Xia, Dandan; Lazoryak, B. I.; Rau, Julietta V.

doi:10.1016/j.ceramint.2022.06.237

Cited by 18 publications

(20 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Noticeable shifts of the positions of reflection peaks would be interpreted as the direct evidence of the incorporation of foreign cations into the crystal lattice of β-TCP. 19 Normally, larger cations tended to inhibit the crystallization of ACP, while the smaller ones promoted. Samples containing Sr showed different degrees of crystallization under 600 °C, while ones containing Ba remained amorphous, which implied that Ba ions possessed the greater potential of maintaining amorphous and might be related to its superior ionic radius.…”

Section: Resultsmentioning

confidence: 99%

“…However, the smaller cations dominated the effect on the crystalline phase when they coexisted, resulting in the formation of pure β-TCP under lower temperature (650 °C) and complete prevention of α-TCP. Noticeable shifts of the positions of reflection peaks would be interpreted as the direct evidence of the incorporation of foreign cations into the crystal lattice of β-TCP . Normally, larger cations tended to inhibit the crystallization of ACP, while the smaller ones promoted.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Competition and Neutralization: Thermally Induced Crystallization and Phase Evolution of Amorphous Calcium Phosphate with Cosubstitution of Larger and Smaller Divalent Cations

Wang

Yang

et al. 2023

ACS Omega

View full text Add to dashboard Cite

The presented study evaluated the effect of cosubstitution of larger and smaller divalent cations on the thermally induced crystallization of amorphous calcium phosphate (ACP). The predesigned combinations of larger (Sr 2+ and Ba 2+ ) and smaller (Mg 2+ , Cu 2+ , and Co 2+ ) divalent cations were carried out and their effects on the thermodynamic equilibrium between α/βtricalcium phosphate (TCP) were outlined. The coexistence of larger and smaller divalent cations shielded the formation of α-TCP and shifted the thermodynamic equilibrium toward the β-TCP, which implied that the smaller cations dominated the crystalline phase. However, the retarded crystallization induced by the larger cations still remained and allowed ACP to maintain its amorphous nature partly or completely until a higher temperature.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Competition and Neutralization: Thermally Induced Crystallization and Phase Evolution of Amorphous Calcium Phosphate with Cosubstitution of Larger and Smaller Divalent Cations

Wang

Yang

et al. 2023

ACS Omega

View full text Add to dashboard Cite

show abstract

“…The majority of the works investigating Cu-substituted CPs are focused on the most popular synthetic phases including calcium hydroxyapatite (HA, Ca 10 (PO 4 ) 6 (OH) 2 ), 7 beta-tricalcium phosphate (β-TCP, Ca 3 (PO 4 ) 2 ), 8–10 brushite (DCPD, CaHPO 4 ·2H 2 O), 11,12 and biphasic CPs (HA + β-TCP). 13 For instance, Cu-doped HA demonstrated an antimicrobial effect against E. coli and C. albicans .…”

Section: Introductionmentioning

confidence: 99%

“…Cu-doped CPs demonstrate antibacterial properties, provide angiogenic ability and favor osteogenesis; these properties represent the key points for ideal biomaterial integration and the healing process. 6 The majority of the works investigating Cu-substituted CPs are focused on the most popular synthetic phases including calcium hydroxyapatite (HA, Ca 10 (PO 4 ) 6 (OH) 2 ), 7 beta-tricalcium phosphate (β-TCP, Ca 3 (PO 4 ) 2 ), [8][9][10] brushite (DCPD, CaHPO 4 •2H 2 O), 11,12 and biphasic CPs (HA + β-TCP). 13 For instance, Cu-doped HA demonstrated an antimicrobial effect against E. coli and C. albicans.…”

Section: Introductionmentioning

confidence: 99%

A copper-containing analog of the biomineral whitlockite: dissolution–precipitation synthesis, structural and biological properties

Griesiute,

Kizalaite,

Dubnika

et al. 2024

Dalton Trans.

View full text Add to dashboard Cite

show abstract

“…The biocidal effect of copper has been widely studied and it has been proven with a myriad of pathogens, bacteria, fungi, as well as viruses. Further copper is effective against methicillin resistant Staphylococcus aureus (MRSA) [ 17 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Three-Dimensional Printed Copper Loaded Calcium Phosphate Scaffolds for Bone Regeneration

et al. 2023

View full text Add to dashboard Cite

Bone regeneration using inorganic nanoparticles is a robust and safe approach. In this paper, copper nanoparticles (Cu NPs) loaded with calcium phosphate scaffolds were studied for their bone regeneration potential in vitro. The pneumatic extrusion method of 3D printing was employed to prepare calcium phosphate cement (CPC) and copper loaded CPC scaffolds with varying wt% of copper nanoparticles. A new aliphatic compound Kollisolv MCT 70 was used to ensure the uniform mixing of copper nanoparticles with CPC matrix. The printed scaffolds were studied for physico-chemical characterization for surface morphology, pore size, wettability, XRD, and FTIR. The copper ion release was studied in phosphate buffer saline at pH 7.4. The in vitro cell culture studies for the scaffolds were performed using human mesenchymal stem cells (hMSCs). The cell proliferation study in CPC-Cu scaffolds showed significant cell growth compared to CPC. The CPC-Cu scaffolds showed improved alkaline phosphatase activity and angiogenic potential compared to CPC. The CPC-Cu scaffolds showed significant concentration dependent antibacterial activity in Staphylococcus aureus. Overall, the CPC scaffolds loaded with 1 wt% Cu NPs showed improved activity compared to other CPC-Cu and CPC scaffolds. The results showed that copper has improved the osteogenic, angiogenic and antibacterial properties of CPC scaffolds, facilitating better bone regeneration in vitro.

show abstract

Antimicrobial properties of co-doped tricalcium phosphates Ca3-2(MˊMˊˊ) (PO4)2 (M = Zn2+, Cu2+, Mn2+ and Sr2+)

Cited by 18 publications

References 47 publications

Competition and Neutralization: Thermally Induced Crystallization and Phase Evolution of Amorphous Calcium Phosphate with Cosubstitution of Larger and Smaller Divalent Cations

Competition and Neutralization: Thermally Induced Crystallization and Phase Evolution of Amorphous Calcium Phosphate with Cosubstitution of Larger and Smaller Divalent Cations

A copper-containing analog of the biomineral whitlockite: dissolution–precipitation synthesis, structural and biological properties

Multifunctional Three-Dimensional Printed Copper Loaded Calcium Phosphate Scaffolds for Bone Regeneration

Contact Info

Product

Resources

About