2015
DOI: 10.1080/09674845.2015.11665749
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Antimicrobial properties of mucus from the brown garden snail Helix aspersa

Abstract: Research into naturally occurring antimicrobial substances has yielded effective treatments. One area of interest is peptides and proteins produced by invertebrates as part of their defence system, including the contents of mollusc mucous. Mucous produced by the African giant land snail, Achatina fulica has been reported to contain two proteins with broad spectrum anti-bacterial activity. Mucous from the brown garden snail, Helix aspersa appears to have skin regenerationproperties. This study sought to investi… Show more

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Cited by 74 publications
(87 citation statements)
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“…This promising result lends support to the view that plant products represent a new opportunity to counter antibiotic resistance [50]. Last year, Pitt et al [51] presented data that an extract of mucus from a snail has antimicrobial activity, a finding confirmed and extended by Bortolotti et al [52] in three common bacteria and Candida albicans. They also provided safety data in that their mucus extract had no critical effect on a transformed human T lymphocyte cell line in vitro.…”
Section: Microbiologysupporting
confidence: 60%
“…This promising result lends support to the view that plant products represent a new opportunity to counter antibiotic resistance [50]. Last year, Pitt et al [51] presented data that an extract of mucus from a snail has antimicrobial activity, a finding confirmed and extended by Bortolotti et al [52] in three common bacteria and Candida albicans. They also provided safety data in that their mucus extract had no critical effect on a transformed human T lymphocyte cell line in vitro.…”
Section: Microbiologysupporting
confidence: 60%
“…This has prompted intense studies of invertebrate species in the last few years. Most of the AMPs found in the hemolymph of invertebrates show activity against a mix of microorganisms including bacteria, viruses, and protozoa [12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%
“…Bakhti and colleagues used molecular genetics to show that cagH, cagL, and orf17 are linked (p = 0.046, p = 0.004, p = 0.01, respectively) to any upper intestinal ulceration, whilst cagG is linked to duodenal, not gastric, ulceration (p = 0.007) [59]. Pitt and colleagues gave us an update [60] on their pursuit of the antibiotic potential of snail mucus, reporting a number of proteins that inhibit the growth of Pseudomonas aeruginosa, the most promising being a 37.4 kDa molecule named Aspernin [61]. The next step in getting Aspernin to the hospital pharmacity is to determine its toxicity, first in cell lines, and then to determine biological activity in an animal model of infection, a pathway that may take a decade to complete.…”
Section: Microbiologymentioning
confidence: 99%