Antimicrobial properties of Teucrium polium against some clinical pathogens

Darabpour, Esmaeil; Motamedi, Hossein; Nejad, Seyyed Mansour Seyyed

doi:10.1016/s1995-7645(10)60050-8

Cited by 70 publications

(40 citation statements)

References 14 publications

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“…None of the tested infusions exhibited antimicrobial activity against Gram-negative bacteria (E. coli ATCC 10535, P. aerugimosa ATCC 27853), or the tested fungi (C. albicans ATCC 10231, A. niger ATCC 16404). Previous studies observed low antibacterial and antifungal activity of T. polium extracts [18,19]. In our study, T. polium showed moderate antibacterial and no antifungal activity.…”

Section: Discussionsupporting

confidence: 44%

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Antimicrobial activity, total phenolic content and flavonoid concentrations of Teucrium species

et al. 2012

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In vitro antimicrobial activity of 21 crude extracts obtained from seven taxa of the genus Teucrium (T. chamaedrys, T. montanum, T. arduini, T. polium, T. scordium subsp. scordium, T. scordium subsp. scordioides and T. botrys) was tested against bacterial and fungal species. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined using a microdilution analysis method. Total phenolic content and flavonoid concentrations were measured spectrophotometrically. Total phenols were determined using Folin-Ciocalteu reagent and their amounts ranged from 28.49 up to 159.84 mg CA/g of extract (chlorogenic acid equivalent). The amounts of flavonoids ranged from 38.17 up to 190.45 mg RU/g of extract (rutin equivalent).The plant extracts showed greater potential of antibacterial than antifungal activity. A relationship was found between total phenolics and biological activity. The highest level of total phenols was measured in the methanol extracts, which demonstrated higher antimicrobial activity than acetone and ethyl acetate extracts. Staphylococcus aureus ATCC 25923 appeared to be the most sensitive organism. Our results indicate that Teucrium spp extracts are rich sources of phenolic compounds and are promising candidates for further development as natural antimicrobial agents.

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Section: Discussionsupporting

confidence: 44%

“…Different extracts of Teucrium montanum were investigated for their antimicrobial activity [16]. The ethyl acetate, n-butanol and chloroform extracts of Teucrium montanum were the most active while the extracts of Teucrium arduini and Teucrium polium showed low antibacterial and antifungal activity [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity, total phenolic content and flavonoid concentrations of Teucrium species

et al. 2012

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“…The minimal inhibitory concentration of Staphylococcus aurous and Salmonella typhi was 40 mg/mL, and that of Bacillus anthracis was 10 mg/mL. The minimal bactericidal concentration against Bacillus anthracis was 10 mg/mL, while its values against other species were not found (> 200 mg/mL) (20). The results obtained by Shahba showed that Teucriumpolium extracts were effective in Enterococcus and Pseudomonas bacteria.…”

Section: Discussionmentioning

confidence: 91%

Investigating the Antibacterial Effects of Plant Extracts on Pseudomonas aeruginosa and Escherichia coli

et al. 2016

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Background: Scientists are seeking an appropriate alternative method for curing infections caused by resistant bacteria, since drug resistance is continually increasing. Objectives: This research aims to discover the function of some medicine plants on pestiferous Pseudomonas aeruginosa and Escherichia coli in humans. Materials and Methods: Bacterial strains were obtained from a standard laboratory. The strains of Pseudomonas aeruginosa ATCC27853 and E.coli ATCC25922 bacteria were used for antimicrobial testing of the extractions. Results: Our results showed that Teucrium polium extracts have the minimum density of inhibitory for Escherichia coli, 25 ppm, whereas the maximum of this is for Peganum harmala and Prangos ferulaceae with 100 ppm. The lowest minimum concentration inhibitory value of extracts P. harmala, T. polium, T. pratensis and Rumex was found in 25 ppm against P.aeruginosa. Conclusions:The results of our study showed that plant extracts have good antibacterial properties against Pseudomonas aeruginosa and Escherichia coli.

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“…14) Our further investigation on this plant led to the isolation of five new neo-clerodane diterpenes, teucvisins A-E (1-5) (Fig. 1), together with ten known diterpenes (6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Herein, we described the isolation and structure elucidation of 1-5 and the anti-inflammatory activities of all the isolates.…”

mentioning

confidence: 94%

“…Teucrium species are generally aromatic and ornamental plants, meanwhile, a large number of species are used in folk medicine and pharmacy for their diverse bioactivities, such as anti-inflammatory, 1) antiacetylcholinesterase, 2) antidiabetic, [3][4][5] antifeedancy 6,7) and antimicrobial effects. 8) Teucrium viscidum, a folk medicine in China, is used to treat hematemesis, pulmonary abscesses, traumatic injuries, and bites from rabid dogs or venomous snakes. 9) Previous phytochemical studies of this plant have afforded diterpenes, [10][11][12][13] triterpenoids, sterols and lignans.…”

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confidence: 99%

Teucvisins A–E, Five New <i>neo</i>-Clerodane Diterpenes from <i>Teucrium viscidum</i>

Luo

Zhu

et al. 2014

Chem. Pharm. Bull.

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Two new neo-clerodane diterpenoids, teucvisins A and B (1, 2), and three new 19-nor-neoclerodane diterpenoids, teucvisins C-E (3-5), together with ten known constituents (6-15) were isolated from the whole plants of Teucrium viscidum. All the isolates were evaluated for their inhibitory activities of lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 macrophages. The results indicated that compounds 11 and 15 showed moderate inhibition with an IC 50 value of 21.9 and 22.4 µM, respectively. Key words clerodane diterpene; Teucrium viscidum; anti-inflammatoryThe genus Teucrium (Lamiaceae) includes approximately 300 species which are mainly distributed in the Mediterranean area. In China, there are eighteen species and ten varieties, mostly distributed in southern part of China. Teucrium species are generally aromatic and ornamental plants, meanwhile, a large number of species are used in folk medicine and pharmacy for their diverse bioactivities, such as anti-inflammatory, 1) antiacetylcholinesterase, 2) antidiabetic, 3-5) antifeedancy 6,7) and antimicrobial effects. 8) Teucrium viscidum, a folk medicine in China, is used to treat hematemesis, pulmonary abscesses, traumatic injuries, and bites from rabid dogs or venomous snakes.9) Previous phytochemical studies of this plant have afforded diterpenes, 10-13) triterpenoids, sterols and lignans.14) Our further investigation on this plant led to the isolation of five new neo-clerodane diterpenes, teucvisins A-E (1-5) (Fig. 1), together with ten known diterpenes (6-15). Herein, we described the isolation and structure elucidation of 1-5 and the anti-inflammatory activities of all the isolates. C-NMR spectrum (Table 1) revealed the presence of 20 carbons, which could in combination with the heteronuclear single quantum coherence (HSQC) and be assigned to two lactone carbonyls (δ C 178.1, 177.8), four olefinic carbons (δ C 144.4, 139.7, 125.2, 108.2), four oxygenated carbons (δ C 78.4, 72.4, 70.1, 69.6) and ten aliphatic resonances (δ C 51.8, 48.4, 42.7, 40.0, 34.2, 33.7, 32.7, 23.5, 21.4, 16.6). The fulfilled analysis of NMR data including HSQC, heteronuclear multiple bond connectivity (HMBC) and rotating frame Overhauser enhancement spectroscopy (ROESY) experiments, allowed for an unambiguous assignment of all proton and carbon signals. The above total data showed that 1 was a neo-clerodane diterpene, whose NMR data were similar to teucrin H2, previously isolated from the genus Teucrium. Results and Discussion

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Antimicrobial properties of Teucrium polium against some clinical pathogens

Cited by 70 publications

References 14 publications

Antimicrobial activity, total phenolic content and flavonoid concentrations of Teucrium species

Antimicrobial activity, total phenolic content and flavonoid concentrations of Teucrium species

Investigating the Antibacterial Effects of Plant Extracts on Pseudomonas aeruginosa and Escherichia coli

Teucvisins A–E, Five New <i>neo</i>-Clerodane Diterpenes from <i>Teucrium viscidum</i>

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