Antimicrobial Prophylaxis in Instrumented Spinal Fusion Surgery: A Comparative Analysis of 24-Hour and 72-Hour Dosages

Abstract

Study DesignProspective study.PurposeTo compare the efficacy of 24-hour and 72-hour antibiotic prophylaxis in preventing surgical site infections (SSIs).Overview of LiteratureAntimicrobial prophylaxis in surgical practice has become a universally accepted protocol for minimizing postoperative complications related to infections. Although prophylaxis is an accepted practice, a debate exists with regard to the antibiotic type and its administration duration for various surgical procedures.MethodsOur institute is a tertiary care hospital with more than 100 spinal surgeries per year for various spine disorders in the department of orthopedics. We conducted this prospective study in our department from June 2012 to January 2015. A total of 326 patients were enrolled in this study, with 156 patients in the 72-hour antibiotic prophylaxis group (group A) and 170 patients in the 24-hour group (group B). Cefazolin was the antibiotic used in both groups. Two surgeons were involved in conducting all the spinal procedures. Our study compared SSIs among patients undergoing instrumented spinal fusion.ResultsThe overall rate of SSIs was 1.8% with no statistical difference between the two groups.ConclusionsThe 24-hour antimicrobial prophylaxis is as effective as the 72-hour dosage in instrumented spinal fusion surgery.

Prophylactic postoperative measures to minimize surgical site infections in spine surgery: systematic review and evidence summary

“…The number of patients in included RCTs ranged from 30 to 326 (Median: 155), whilst that in cohort studies ranged from 42 to 10,225 (Median: 265.5). 17 of 30 12,15,18,21,22,[24][25][26]31,32,35,40,42,43,45,47,48 There is insufficient evidence to provide recommendations on postoperative AMP administration to reduce the rate of SSI in other types of spine surgery.…”

Clinical Pharmacology in India-A Systematic Review of Research in the Past 5 Years

“…An important aspect of antimicrobial use was evaluated in a prospective study undertaken to compare surgical site infections in spinal surgeries following 24-hour versus 72-hour antimicrobial prophylaxis (Marimuthu et al, 2016). No significant difference in surgical site infections was noted.…”

Artroplastia de quadril em idosos hospitalizados e o uso de antibioticoprofilaxia

“…A profilaxia antimicrobiana nos procedimentos cirúrgicos integra os protocolos recomendados para minimizar essas complicações, 3,4 o seu não cumprimento pode aumentar o risco de infecções além de não justificar os riscos aos pacientes e os custos ao sistema de saúde. 5,6 Dados epidemiológicos da região norte do estado sobre a temática não foram encontrados, assim, o objetivo deste estudo, foi descrever o perfil epidemiológico e clínico de idosos hospitalizados para artroplastia de quadril e verificar a adesão aos protocolos de antibioticoprofilaxia em cirurgias de quadril, ressaltando a importância RESUMEN Justificación y objetivos: El envejecimiento poblacional aumenta los riesgos de fracturas de cadera y de complicaciones postoperatorias provenientes de cirugías, pudiendo causar morbilidad y la reinternación de esos pacientes. Las recomendaciones para orientar a los profesionales en relación con los cuidados necesarios para que las infecciones de sitios quirúrgicos (ISC) puedan ser evitadas o minimizadas.…”