Antimicrobial Prophylaxis Using a 2nd Generation Cephalosporin after Laparoscopic Colorectal Resection: A Randomized Trial of 1-day vs. 3-day

Abstract

Purpose:We performed this study to compare 1-day group using a 2nd generation cephalsporin with 3-day group for evaluating hospital acquired infection. Methods: The patients underwent laparoscopic colorectal surgery at Korea University Medical Center Anam Hospital, from August, 2007 to June, 2008. They were randomly allocated to 2 groups: 1-day or 3-day group. A 2nd generation cephalosporin was administered within 1 hour before surgery with 12-hour intervals. In cases of suspected infection, further studies were done to identify infection. Results: The study included 154 patients (1-day group -78, vs. 3-day group -76). No differences were noted between the 2 groups in age, body mass index, smoking, diabetes mellitus, corticosteroid-use were noted. Gender (P=0.011) and mean operative time (P=0.047) between the 2 groups were different. The preventive rates of infection were 87.18% in the 1-day group compared with 82.89% in the 3-day group (P=0.456). Conclusion: Our prospective randomized control study concluded that there were no differences between the 1-day and 3-day group in hospital acquired infection. We could come to the conclusion that 1-day antimicrobial agent in laparoscopic colorectal surgery would be adequate in preventing infection. (J Korean Surg Soc 2010;78:385-389)

Impact of a national hospital evaluation program using clinical performance indicators on the use of surgical antibiotic prophylaxis in Korea

“…[4][5][6][7] In spite of the longer use of SAP in the present study, some recent randomized controlled trials in Korea have demonstrated that shorter and longer durations of SAP are comparable for preventing SSIs. 27,28 Third, an absence of intraoperative redosing was the other important issue of SAP inappropriateness in the present study. Additional doses of antibiotics are generally recommended if the duration of the surgical procedure is longer than twice the half-life of the antibiotics.…”