Antimicrobial pterocarpans of nigerian Erythrina mildbraedii

Mitscher, Lester A.; Okwute, Simon Koma; Gollapudi, Rao; Drake, Steven D.; Avona, Elizabeth

doi:10.1016/0031-9422(88)80746-5

Cited by 70 publications

(59 citation statements)

References 10 publications

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“…170 The genus Erythrina of the family Leguminosae comprises over 110 species that are widely distributed in tropical and subtropical regions, and representative species have been used in indigenous medicine. 171,172 In a continuing effort to search for natural PTP 1B inhibitors, Na et al reported three new 2-arylbenzofurans isolated from the stem bark of Erythrina addisoniae, which were found to exhibit potent in vitro PTP 1B inhibitory activities. Results from both studies indicated that presence of a lipophilic group (methoxy and/or prenyl residues) on the B ring seemed to increase the inhibitory effect of these flavanoids against PTP 1B, while the presence of a polar moiety (hydroxy group) did not seem to affect their biological activity.…”

Section: O Isoxazole Carboxylic Acidsmentioning

confidence: 98%

Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus

Thareja

Aggarwal

Bhardwaj

et al. 2010

Medicinal Research Reviews

111

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Diabetes mellitus is a systemic disease responsible for morbidity in the western world and is gradually becoming prevalent in developing countries too. The prevalence of diabetes is rapidly increasing in industrialized countries and type 2 diabetes accounts for 90% of the disease. Insulin resistance is a major pathophysiological factor in the development of type 2 diabetes, occurring mainly in muscle, adipose tissues, and liver leading to reduced glucose uptake and utilization and increased glucose production. The prevalence and rising incidence of diabetes emphasized the need to explore new molecular targets and strategies to develop novel antihyperglycemic agents. Protein Tyrosine Phosphatase 1B (PTP 1B) has recently emerged as a promising molecular level legitimate therapeutic target in the effective management of type 2 diabetes. PTP 1B, a cytosolic nonreceptor PTPase, has been implicated as a negative regulator of insulin signal transduction. Therefore, PTP 1B inhibitors would increase insulin sensitivity by blocking the PTP 1B-mediated negative insulin signaling pathway and might be an attractive target for type 2 diabetes mellitus and obesity. With X-ray crystallography and NMR-based fragment screening, the binding interactions of several classes of inhibitors have been elucidated, which could help the design of future PTP 1B inhibitors. The drug discovery research in PTP 1B is a challenging area to work with and many pharmaceutical organizations and academic research laboratories are focusing their research toward the development of potential PTP 1B inhibitors which would prove to be a milestone for the management of diabetes.

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Section: O Isoxazole Carboxylic Acidsmentioning

confidence: 98%

Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus

Thareja

Aggarwal

Bhardwaj

et al. 2010

Medicinal Research Reviews

111

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“…6-58, 52 and 53) and isoneorautenol ( Fig. 6-61) from Nigerian legume species, Erythrina mildbraedii were shown to be antimicrobial against Staphylococcus aureus and Mycobacterium smegmatis (Mitscher et al, 1988). However, accompanied alkaloids fractions were inactive.…”

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confidence: 99%

Flavonoid Function and Activity to Plants and Other Organisms

Iwashina

2003

Biol. Sci. Space

152

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Flavonoid compounds distribute widely in vascular plants and Bryophytes, and ca. 5,000 kinds have been reported as naturally occurring substances. Many biological activities of the flavonoids were found until now. They include pollinator attractants, oviposition stimulants, feeding attractants and deterrents, allelopathy and phytoalexins. This paper reviews function and activity of flavonoids against plants and other organisms.Key words: flavonoids, pollinator attractants, feeding attractants and deterrents, allelopathy, phytoalexins di-P-coumaroylglucoside) and quercetin 3-O-(3´´,6´´-di-P-coumaroylglucoside) in Pinus sylvestris (Pinaceae) (Jungblut et al., 1995), quercetin 3-O-galactoside, myricetin 3-O-rutinoside and two P-coumaroyl kaempferol 3-Oglucoside in Quercus ilex (Fagaceae) (Skaltsa et al., 1994), and glycosides of quercetin, apigenin and luteolin in Olea europea (Oleaceae) (Karabourniotis et al., 1992) The occurrence of anthocyanins as pollinator attractants is well-known as a function of the flavonoids in plants. Additionally, it is known that flavones and flavonols, which can hardly see by human eyes, also act as pollinator attractants in addition to visible anthocyanins. Recently, other functions, oviposition stimulants, feeding attractants, feeding deterrents, allelopathy and phytoalexins of naturally occurring flavonoids, were found by many authors.In this paper, the flavonoid function and activity to plants and other organisms are reviewed.

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“…Three pterocarpans, erybraedin A, B and C, isolated from the roots of Erythrina mildbraedii, were reported to be active against Staphylococcus aureus ATCC 13709 and Mycobacterium smegmatis ATCC 607 (Mitscher et al, 1988). The pterocarpene erycristagallin, isolated from the same species, has been reported to exhibit antiinflammatory activity (Njamen et al, 2003).…”

Section: Introductionmentioning

confidence: 99%