Antimicrobial releasing hydrogel forming microneedles

Turner, Joseph G.; Laabei, Maisem; Li, Shuxian; Estrela, Pedro; Leese, Hannah S.

doi:10.1016/j.bioadv.2023.213467

Cited by 17 publications

(13 citation statements)

References 46 publications

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“…This study also evidenced a comparison between the developed microneedles and commercially available microneedle molds, which were produced by laser-etch molding, in terms of porcine skin penetration performance. In this way, it was demonstrated a comparable performance between the two with a difference of 9 % penetration rate in microneedle penetration at the minimum penetrative force required [301]. 4.9.4.…”

Section: Materials Jetting (Mj)mentioning

confidence: 78%

“…In turn, the results of drug loading capacity and drug release profiles evidenced that transdermal microneedles could be well programmed with sophisticated morphologies and predesigned surface areas to achieve both sufficient drug loading capacity and desired drug release profiles [300]. Turner et al developed a transdermal drug delivery microneedle platform, that exhibits successful skin penetration, provides effective controlled drug-release, and are manufactured by a quick, low-cost, flexible SLA 3D printing micro-molding process [301]. In fact, they fabricated 3D printed microneedle templates, which were optimized and used in a micromolding process to form negative PDMS molds, that subsequently were used in the manufacture of hydrogel-forming microneedles.…”

Section: Materials Jetting (Mj)mentioning

confidence: 99%

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Microneedles Patch: Design, Fabrication and Applications

Oliveira,

Teixeira,

Oliveira

et al. 2024

Preprint

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The delivery of therapeutical molecules through the skin, particularly to its deeper layers is impaired due to the stratum corneum layer, which acts as barrier to foreign substances. Thus, for the past years, scientists have focused on the development of more efficient methods to deliver molecules to skin distinct layers. Microneedles, as a new class of biomedical devices, consists on an array of microscale needles. This particular biomedical device had been drawing attention due to their ability to breach the stratum corneum, forming micro-conduits to facilitate the passage of therapeutical molecules. The microneedle device has several advantages over conventional methods, such as better medication adherence, easiness and painless self-administration. Moreover, it is possible to deliver the molecules swiftly or over time. Microneedles can vary in shape, size and composition. The design process of a microneedle device must take in account several factors, like the location delivery, the material and manufacturing process. Microneedles have been used in a large number of fields from drug and vaccine application, cosmetics, therapy, diagnosis, tissue engineering, sample extraction, cancer research, wound healing, among others.

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Section: Materials Jetting (Mj)mentioning

confidence: 78%

Section: Materials Jetting (Mj)mentioning

confidence: 99%

Microneedles Patch: Design, Fabrication and Applications

Oliveira,

Teixeira,

Oliveira

et al. 2024

Preprint

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show abstract

“…The microneedles will be removed after use and not remain in the tissue. 64 Turner et al 65 used swelling microneedles to absorb and release drugs (Fig. 2(d)).…”

Section: Microneedlementioning

confidence: 99%

Applications and prospects of microneedles in tumor drug delivery

Zhang,

Liu,

2024

J. Mater. Chem. B

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“…Another study investigated the use of HFM for transdermal drug delivery of antibiotics, demonstrating controlled release properties and potent antimicrobial activity against Escherichia coli and Staphylococcus aureus . The microneedles were fabricated using a custom design 3D-printed master template to improve resolution and successful penetration of porcine skin grafts [ 159 ]. In the future, there is a potential to develop hydrogel MNs that can target specific bacterial strains in the oral cavity, such as S. mutans , which is a major contributor to dental caries.…”

Section: Future Perspectivesmentioning

confidence: 99%

Hydrogel-Forming Microneedles with Applications in Oral Diseases Management

et al. 2023

Materials

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Controlled drug delivery in the oral cavity poses challenges such as bacterial contamination, saliva dilution, and inactivation by salivary enzymes upon ingestion. Microneedles offer a location-specific, minimally invasive, and retentive approach. Hydrogel-forming microneedles (HFMs) have emerged for dental diagnostics and therapeutics. HFMs penetrate the stratum corneum, undergo swelling upon contact, secure attachment, and enable sustained transdermal or transmucosal drug delivery. Commonly employed polymers such as polyvinyl alcohol (PVA) and polyvinyl pyrrolidone are crosslinked with tartaric acid or its derivatives while incorporating therapeutic agents. Microneedle patches provide suture-free and painless drug delivery to keratinized or non-keratinized mucosa, facilitating site-specific treatment and patient compliance. This review comprehensively discusses HFMs’ applications in dentistry such as local anesthesia, oral ulcer management, periodontal treatment, etc., encompassing animal experiments, clinical trials, and their fundamental impact and limitations, for example, restricted drug carrying capacity and, until now, a low number of dental clinical trial reports. The review explores the advantages and future perspectives of HFMs for oral drug delivery.

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Antimicrobial releasing hydrogel forming microneedles

Cited by 17 publications

References 46 publications

Microneedles Patch: Design, Fabrication and Applications

Microneedles Patch: Design, Fabrication and Applications

Applications and prospects of microneedles in tumor drug delivery

Hydrogel-Forming Microneedles with Applications in Oral Diseases Management

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