Antimicrobial research of carbohydrate polymer- and protein-based hydrogels as reservoirs for the generation of reactive oxygen species: A review

Liu, Lan; Fan, Xin; Lu, Qianyun; Wang, Pengxu; Wang, Xingang; Han, Yuxing; Wang, Runming; Zhang, Canyang; Han, Sanyang; Tsuboi, Tatsuhisa; Dai, Hongliang; Yeow, Jonathan; Geng, Hongya

doi:10.1016/j.ijbiomac.2024.129251

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.129251

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Antimicrobial research of carbohydrate polymer- and protein-based hydrogels as reservoirs for the generation of reactive oxygen species: A review

Lan Liu,

Xin Fan,

Qianyun Lu

et al.

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Cited by 4 publications

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Injectable pH‐ and Ultrasound‐Responsive Dual‐Crosslinked Dextran/Chitosan/TiO₂ Nanocomposite Hydrogels for Antibacterial Applications

Yan,

Yang,

Yeh

2024

Chemistry An Asian Journal

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Combining exogenous and endogenous antibacterial mechanisms has been demonstrated to enhance therapeutic efficacy significantly. This study constructs an innovative type of exogenous and endogenous antibacterial nanocomposite hydrogels with injectable dual‐crosslinked networks and dual‐stimuli responsiveness. The primary network establishes imine bonds between the functionalized dextran featuring norbornenes and aldehydes (NorAld‐Dex) and the quaternized chitosan (QCS). The imine bonds provide self‐healing, injectability, and pH‐responsiveness to the hydrogel network. The secondary network is established by integrating thiolated mesoporous silica‐coated titanium dioxide nanoparticles (TiO2@MS‐SH) into the hydrogel network via an ultrasound‐activated thiol‐norbornene reaction with NorAld‐Dex. The microstructures and properties of NorAld‐Dex/QCS/TiO2@MS‐SH hydrogels can be fine‐tuned by adjusting the sonication time to increase the amount of thiol‐norbornene crosslinks in the network. Effective antibacterial performance of NorAld‐Dex/QCS/TiO2@MS‐SH hydrogels at low pH has been demonstrated with the synergistic effect of the acid‐induced dissociation of the hydrogel network, protonated QCS, and the reactive oxygen species (ROS) generated by TiO2@MS‐SH nanoparticles under ultrasound irradiation. In summary, NorAld‐Dex/QCS/TiO2@MS‐SH hydrogel is an advanced dual stimuli‐responsive antibacterial platform with customizable microstructures and properties, offering great potential for biomedical applications.

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Injectable pH‐ and Ultrasound‐Responsive Dual‐Crosslinked Dextran/Chitosan/TiO₂ Nanocomposite Hydrogels for Antibacterial Applications

Yan,

Yang,

Yeh

2024

Chemistry An Asian Journal

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The optimization of in situ exopolysaccharides production in Lactobacillus helveticus MB2-1 fermented milk and its functional characteristics in vitro

Ge,

Wang,

Azi

et al. 2024

International Dairy Journal

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A comprehensive review on the inherent and enhanced antifouling mechanisms of hydrogels and their applications

Cui,

Liu,

Chen

et al. 2024

International Journal of Biological Macromolecules

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Antimicrobial research of carbohydrate polymer- and protein-based hydrogels as reservoirs for the generation of reactive oxygen species: A review

Cited by 4 publications

References 141 publications

Injectable pH‐ and Ultrasound‐Responsive Dual‐Crosslinked Dextran/Chitosan/TiO₂ Nanocomposite Hydrogels for Antibacterial Applications

Injectable pH‐ and Ultrasound‐Responsive Dual‐Crosslinked Dextran/Chitosan/TiO₂ Nanocomposite Hydrogels for Antibacterial Applications

The optimization of in situ exopolysaccharides production in Lactobacillus helveticus MB2-1 fermented milk and its functional characteristics in vitro

A comprehensive review on the inherent and enhanced antifouling mechanisms of hydrogels and their applications

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About

Antimicrobial research of carbohydrate polymer- and protein-based hydrogels as reservoirs for the generation of reactive oxygen species: A review

Cited by 4 publications

References 141 publications

Injectable pH‐ and Ultrasound‐Responsive Dual‐Crosslinked Dextran/Chitosan/TiO2 Nanocomposite Hydrogels for Antibacterial Applications

Injectable pH‐ and Ultrasound‐Responsive Dual‐Crosslinked Dextran/Chitosan/TiO2 Nanocomposite Hydrogels for Antibacterial Applications

The optimization of in situ exopolysaccharides production in Lactobacillus helveticus MB2-1 fermented milk and its functional characteristics in vitro

A comprehensive review on the inherent and enhanced antifouling mechanisms of hydrogels and their applications

Contact Info

Product

Resources

About

Injectable pH‐ and Ultrasound‐Responsive Dual‐Crosslinked Dextran/Chitosan/TiO₂ Nanocomposite Hydrogels for Antibacterial Applications

Injectable pH‐ and Ultrasound‐Responsive Dual‐Crosslinked Dextran/Chitosan/TiO₂ Nanocomposite Hydrogels for Antibacterial Applications