Antimicrobial resistance – A global problem in need of global solutions

Petersen, Eskild; Lee, Shui Shan; Blumberg, Lucille; Levison, Matthew E.

doi:10.1016/j.ijid.2023.10.009

Cited by 2 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The problem of drug resistance caused by antibiotic abuse is still an important problem that researchers need to solve [75]. Most of the research results in this review illustrate that QSIs are likely to improve the antibacterial effect of antibiotics by inhibiting and eliminating bacterial biofilm barriers.…”

Section: Discussionmentioning

confidence: 94%

Research Progress on the Combination of Quorum-Sensing Inhibitors and Antibiotics against Bacterial Resistance

Wang,

Lu,

Wang

et al. 2024

Molecules

View full text Add to dashboard Cite

Bacterial virulence factors and biofilm development can be controlled by the quorum-sensing (QS) system, which is also intimately linked to antibiotic resistance in bacteria. In previous studies, many researchers found that quorum-sensing inhibitors (QSIs) can affect the development of bacterial biofilms and prevent the synthesis of many virulence factors. However, QSIs alone have a limited ability to suppress bacteria. Fortunately, when QSIs are combined with antibiotics, they have a better therapeutic effect, and it has even been demonstrated that the two together have a synergistic antibacterial effect, which not only ensures bactericidal efficiency but also avoids the resistance caused by excessive use of antibiotics. In addition, some progress has been made through in vivo studies on the combination of QSIs and antibiotics. This article mainly expounds on the specific effect of QSIs combined with antibiotics on bacteria and the combined antibacterial mechanism of some QSIs and antibiotics. These studies will provide new strategies and means for the clinical treatment of bacterial infections in the future.

show abstract

Section: Discussionmentioning

confidence: 94%

Research Progress on the Combination of Quorum-Sensing Inhibitors and Antibiotics against Bacterial Resistance

Wang,

Lu,

Wang

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

“…When overwhelming numbers of cases with RTIs occur widespread empiric overuse of antibiotics inevitably follows. Antimicrobial stewardship and proactive surveillance remain important strategies in controlling the global problem of antimicrobial resistance which is accelerated by the misuse and overuse of antibiotics during epidemics of respiratory infections [ 14 ]. With advancing developments in accurate multiplex diagnostic screening for multiple pathogens simultaneously from a single clinical samples, further investments into development of more accurate, affordable, easy to use point-of-care diagnostic tests are required.…”

mentioning

confidence: 99%