2019
DOI: 10.1371/journal.pone.0223598
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Antimicrobial resistance (AMR) and molecular characterization of Neisseria gonorrhoeae in Ghana, 2012-2015

Abstract: Neisseria gonorrhoeae antimicrobial resistance (AMR) surveillance is essential for tracking the emergence and spread of AMR strains in local, national and international populations. This is crucial for developing or refining treatment guidelines. N. gonorrhoeae multiantigen sequence typing (NG-MAST) is beneficial for describing the molecular epidemiology of gonococci at national and international levels. Elucidation of AMR determinants to β-lactam drugs, is a means of monitoring the development of resistance. … Show more

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Cited by 22 publications
(20 citation statements)
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“…In Ghana, 88.1% of 44 analysed gonococcal isolates obtained from symptomatic patients were ciprofloxacin resistant. 20 Resistance of gonococci to benzylpenicillin and tetracycline is universal and both antimicrobials are not recommended for gonorrhoea treatment. We found that the resistance to benzylpenicillin was mostly plasmid mediated.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In Ghana, 88.1% of 44 analysed gonococcal isolates obtained from symptomatic patients were ciprofloxacin resistant. 20 Resistance of gonococci to benzylpenicillin and tetracycline is universal and both antimicrobials are not recommended for gonorrhoea treatment. We found that the resistance to benzylpenicillin was mostly plasmid mediated.…”
Section: Discussionmentioning
confidence: 99%
“…In Ghana, 88.1% of 44 analysed gonococcal isolates obtained from symptomatic patients were ciprofloxacin resistant. 20…”
Section: Discussionmentioning
confidence: 99%
“…Following these reports the use of both penicillin and tetracycline for treatment of gonococcal infections was stopped [ 42 ]. Nevertheless, the two drugs are widely available to the public and are inappropriately used through self prescription in many parts of Africa including Kenya [ 43 – 45 ].…”
Section: Introductionmentioning
confidence: 99%
“…In Zimbabwe, Gram-negative bacteria showed high resistant to Cotrimoxazole (68.5%) and Ampicillin (84.5%) while Gram-positive bacteria demonstrated resistance to Cotrimoxazole (69%) and Nalidixic acid (81%) [6]. A study in Ghana revealed that Neisseria gonorrhoeae isolates were resistant to tetracycline (100%), benzylpenicillin (90.9%) and cipro oxacin (88.6%) [7]. In general, key Gram-negative (including Klesbsiella, E. coli, Salmonella, Shigella) and Grampositive bacteria (such as S. pneumoniae, S. aureus, S. agalactae, MRSA) across sSA have acquired resistance to the common essential antimicrobials being used in the region [8].…”
Section: Introductionmentioning
confidence: 99%